SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_025195
Gene Symbol:	TRIB1
Description:	Homo sapiens tribbles homolog 1 (Drosophila) (TRIB1), mRNA.
Gene Location:	chr8(+):126442562-126450644
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.125436611C>G			COSN195106		PD4116a		[breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1253	gcgcctccTCTTCTCTgtt	0	AGAGAAGA	m8a	Disrupted	-0.093000	-0.019000	1.530000
hsa-miR-3925-5p	gcgcctcctGTTCTCTgtt	0	AAGAGAAC	m7b	(m6c->m7b)	no TS	-0.106000	-0.100000
hsa-miR-4459	gcgCCTCCTGttctctgtt	0	CCAGGAGG	m7b	(m6b->m7b)	no TS	-0.138000	No effect
hsa-miR-4695-5p	gcGCCTCCTGttctctgtt	1	CAGGAGGC	m8a	(m7a->m8a)	-0.185000	-0.185000	No effect
hsa-miR-4773	gcgcctcCTGTTCTctgtt	0	CAGAACAG	m7b	Created	no TS	-0.052000	No effect
hsa-miR-5197-3p	gcgcctcCTCTTCTctgtt	0	AAGAAGAG	m7b	Disrupted	-0.123000	-0.064000	No effect
hsa-miR-1253	gcgcctccTCTTCTCTgtt	0	AGAGAAGA	m8a	Disrupted	-0.093	-0.019	1.53
hsa-miR-3925-5p	gcgcctcctGTTCTCTgtt	0	AAGAGAAC	m7b	(m6c->m7b)	no TS	-0.106	-0.1
hsa-miR-4459	gcgCCTCCTGttctctgtt	0	CCAGGAGG	m7b	(m6b->m7b)	no TS	-0.138	No effect
hsa-miR-4695-5p	gcGCCTCCTGttctctgtt	0	CAGGAGGC	m8a	(m7a->m8a)	-0.185	-0.185	No effect
hsa-miR-4773	gcgcctcCTGTTCTctgtt	0	CAGAACAG	m7b	Created	no TS	-0.052	No effect
hsa-miR-5197-3p	gcgcctcCTCTTCTctgtt	2	AAGAAGAG	m7b	Disrupted	-0.123	-0.064	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.125437932A>G			COSN2259632		RK083_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4662b	caggcagtCATCTTTaagg	6	AAAGAUGG	m7a	Disrupted	-0.130000	-0.130000	No effect
hsa-miR-5002-3p	caGGCAGTCAtctttaagg	0	UGACUGCC	m8a	(m8a->m7a)	-0.429000	-0.239000	2.450000
hsa-miR-548u	caggcagtcGTCTTTaagg	0	CAAAGACU	m6b	Created	no TS	-0.011000	No effect
hsa-miR-4662b	caggcagtCATCTTTaagg	0	AAAGAUGG	m7a	Disrupted	-0.13	-0.13	No effect
hsa-miR-5002-3p	caGGCAGTCAtctttaagg	0	UGACUGCC	m8a	(m8a->m7a)	-0.429	-0.239	2.45
hsa-miR-548u	caggcagtcGTCTTTaagg	0	CAAAGACU	m6b	Created	no TS	-0.011	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.125438049G>A			COSN14843154		8057559		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3163	ttcgATTTTATtttgtttt	12	UAUAAAAU	m7b	Created	0.106000	0.158000	-0.570000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.125438204T>A			COSN6911138		RK128_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3677-5p	acagaGGCCACTGtcgcac	0	CAGUGGCC	m8a	Created	no TS	-0.238000	-8.630000
hsa-miR-4757-5p	acAGAGGCCTctgtcgcac	7	AGGCCUCU	m8a	(m8a->m7a)	-0.165000	-0.332000	-2.950000
hsa-miR-5693	acagagGCCACTGtcgcac	0	GCAGUGGC	m7b	Created	no TS	-0.140000	-10.450000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.125438304A>G			COSN6911139		RK136_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3180-5p	gggaaagCTGGAAacacta	0	CUUCCAGA	m6b	Created	no TS	-0.083000	-0.020000
hsa-miR-4267	gggaaAGCTGGAaacacta	0	UCCAGCUC	m7a	Created	no TS	-0.143000	-0.120000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
125438062	rs191786446	T
			C	hsa-miR-4773 hsa-miR-589-3p	1 1	tttgttCTGTTCT ttTGTTCTGttct	Created Created	N N	-0.113 -0.101

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