| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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| RefSeq ID: | NM_013381 |
|---|---|
| Gene Symbol: | TRHDE |
| Description: | Homo sapiens thyrotropin-releasing hormone degrading enzyme (TRHDE), mRNA. |
| Gene Location: | chr12(+):72666528-73059422 |
| Browse Associations | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr12:g.72663247C>A | COSN5952093 | RK205_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-100-3p |
gagaagaCAAGCTTtttgt |
0 | CAAGCUUG | m7b | Created | no TS | -0.245000 |
-0.150000 |
|
| hsa-miR-187-3p |
gagaAGACACGctttttgt |
1 |
UCGUGUCU | m7b | Disrupted | -0.295000 | no TS |
0.090000 |
|
| hsa-miR-4711-3p |
gagAAGACACGctttttgt |
2 |
CGUGUCUU | m8a | Disrupted | -0.156000 | no TS |
3.280000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr12:g.72663292G>C | COSN9475433 | AOCS-117-3-3 | [ovary][NS][other][neoplasm] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-3126-3p |
aaatgGCCAGATtttcagt |
0 | CAUCUGGC | m7b | Disrupted | -0.260000 | no TS |
5.510000 |
|
| hsa-miR-3176 |
aaatGGCCAGattttcagt |
9 |
ACUGGCCU | m6b | Disrupted | -0.330000 | -0.097000 | No effect | |
| hsa-miR-3190-5p |
aaaTGGCCAGAttttcagt |
0 | UCUGGCCA | m8a | Disrupted | -0.500000 | no TS |
3.220000 |
|
| hsa-miR-3662 |
aaatggccaCATTTTCagt |
2 |
GAAAAUGA | m7a | (m6b->m7a) | 0.210000 | 0.210000 | No effect | |
| hsa-miR-4668-3p |
aaatggccaGATTTTCagt |
0 | GAAAAUCC | m7a | (m7a->m6b) | NA | NA |
0.380000 |
|
| hsa-miR-663b |
aaatGGCCACattttcagt |
0 | GGUGGCCC | m6b | Created | no TS | -0.238000 |
-3.660000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr12:g.72663332T>G | COSN8586663 | 783_T | [lung][NS][carcinoma][squamous_cell_carcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-548ae |
tttttttAGTTTTTatttt |
0 | CAAAAACU | m7b | Disrupted | -0.050000 | 0.111000 |
0.720000 |
|
| hsa-miR-548ah-3p |
tttttttAGTTTTTatttt |
0 | CAAAAACU | m7b | Disrupted | -0.042000 | 0.108000 |
0.450000 |
|
| hsa-miR-548aj-3p |
tttttttAGTTTTTAtttt |
0 | UAAAAACU | m8a | Disrupted | -0.039000 | 0.111000 |
0.110000 |
|
| hsa-miR-548am-3p |
tttttttAGTTTTTatttt |
0 | CAAAAACU | m7b | Disrupted | -0.042000 | 0.108000 |
0.100000 |
|
| hsa-miR-548aq-3p |
tttttttAGTTTTTatttt |
0 | CAAAAACU | m7b | Disrupted | -0.039000 | 0.111000 |
0.930000 |
|
| hsa-miR-548at-3p |
tttttttaGGTTTTatttt |
0 | CAAAACCG | m6b | Created | -0.213000 | -0.328000 |
0.010000 |
|
| hsa-miR-548e |
tttttttAGTTTTTatttt |
0 | AAAAACUG | m7a | Disrupted | NA | NA |
0.280000 |
|
| hsa-miR-548f |
tttttttAGTTTTTatttt |
0 | AAAAACUG | m7a | Disrupted | NA | NA |
0.020000 |
|
| hsa-miR-548x-3p |
tttttttAGTTTTTAtttt |
0 | UAAAAACU | m8a | Disrupted | -0.050000 | 0.111000 |
0.170000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr12:g.72663576T>G | COSN1583871 | RK067_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-3692-5p |
gttCCAGCAGGcttatttc |
0 | CCUGCUGG | m8a | Created | no TS | -0.187000 |
-6.010000 |
|
| hsa-miR-370 |
gttcCAGCAGGCttatttc |
0 | GCCUGCUG | m8a | Created | no TS | -0.171000 |
-0.010000 |
|
| hsa-miR-596 |
gttccaGCAGGCTTatttc |
0 | AAGCCUGC | m8a | Created | no TS | -0.242000 |
-5.560000 |
|
| hsa-miR-3692-5p |
gttCCAGCAGGcttatttc |
0 | CCUGCUGG | m8a | Created | no TS | -0.187 |
-6.01 |
|
| hsa-miR-370 |
gttcCAGCAGGCttatttc |
0 | GCCUGCUG | m8a | Created | no TS | -0.171 |
-0.01 |
|
| hsa-miR-596 |
gttccaGCAGGCTTatttc |
0 | AAGCCUGC | m8a | Created | no TS | -0.242 |
-5.56 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr12:g.72663792A>C | COSN15095384 | LP6005409-DNA_E02 | [oesophagus][NS][carcinoma][adenocarcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1179 |
ctggcAATGCTTactgtgt |
0 | AAGCAUUC | m7a | Created | NA | NA |
-0.060000 |
|
| hsa-miR-382-3p |
ctggcAATGATTactgtgt |
0 | AAUCAUUC | m7a | Disrupted | -0.075000 | -0.075000 |
5.590000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr12:g.72663909T>G | COSN9754948 | C0019T | [kidney][NS][other][neoplasm] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-3529-3p |
tatatagtaTGTTGTacac |
9 |
AACAACAA | m6b | Disrupted | -0.008000 | no TS | No effect | |
| hsa-miR-4714-3p |
tatatagTAGGTTGtacac |
0 | CCAACCUA | m7b | Created | no TS | -0.112000 | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr12:g.72664255T>G | COSN8121513 | PCSI_0164_Pa_P_526 | [pancreas][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-4261 |
aagagtttaGTTTCCatct |
0 | AGGAAACA | m6b | Created | no TS | -0.015000 | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr12:g.72664476G>T | COSN5952094 | RK181_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-33b-3p |
tttcttttGGCACTGacaa |
0 | CAGUGCCU | m7a | Disrupted | NA | NA |
1.990000 |
|
| hsa-miR-4276 |
tttcttttgTCACTGAcaa |
4 |
CUCAGUGA | m7b | (m6c->m7b) | -0.157000 | -0.163000 |
-0.070000 |
|
| hsa-miR-4504 |
tttcttTTGTCACtgacaa |
0 | UGUGACAA | m7b | Created | no TS | -0.070000 |
-10.610000 |
|
| hsa-miR-5190 |
tttcttttGTCACTGacaa |
0 | CCAGUGAC | m7b | Created | no TS | -0.130000 |
-1.820000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr12:g.72664730T>C | COSN1583872 | RK159_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-30a-3p |
tacaaatcACTGAAAGaaa |
2 |
CUUUCAGU | m8a | Created | 0.027000 | -0.001000 |
-0.020000 |
|
| hsa-miR-30d-3p |
tacaaatcACTGAAAGaaa |
2 |
CUUUCAGU | m8a | Created | 0.027000 | -0.001000 |
-0.250000 |
|
| hsa-miR-30e-3p |
tacaaatcACTGAAAGaaa |
2 |
CUUUCAGU | m8a | Created | 0.027000 | -0.001000 |
-1.170000 |
|
| hsa-miR-4276 |
tacaaaTCACTGAaagaaa |
4 |
CUCAGUGA | m7b | Created | -0.157000 | -0.373000 |
-2.260000 |
|
| hsa-miR-5190 |
tacaaaTCACTGaaagaaa |
0 | CCAGUGAC | m6b | Created | no TS | -0.059000 |
-1.870000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr12:g.72664731T>G | COSN8121514 | ASHPC_0006_Pa_P | [pancreas][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-3124-3p |
acaaatcatGGAAAGaaat |
0 | ACUUUCCU | m6b | Created | no TS | -0.027000 | No effect | |
| hsa-miR-5581-3p |
acaaatCATGGAAagaaat |
7 |
UUCCAUGC | m7a | Created | -0.252000 | -0.331000 |
-4.370000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr12:g.72664812T>A | COSN1583873 | RK004_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-32-3p |
gaattatttTAAATTagta |
3 |
CAAUUUAG | m6b | Disrupted | 0.149000 | 0.047000 |
-0.010000 |
|
| hsa-miR-4775 |
gaattatttAAAATTAgta |
3 |
UUAAUUUU | m7b | (m6c->m7b) | 0.266000 | 0.312000 |
-1.020000 |
|
| hsa-miR-590-3p |
gaattattTAAAATTAgta |
14 |
UAAUUUUA | m8a | Created | 0.336000 | 0.442000 |
-0.510000 |
|
| hsa-miR-32-3p |
gaattatttTAAATTagta |
0 | CAAUUUAG | m6b | Disrupted | 0.149 | 0.047 |
-0.01 |
|
| hsa-miR-4775 |
gaattatttAAAATTAgta |
0 | UUAAUUUU | m7b | (m6c->m7b) | 0.266 | 0.312 |
-1.02 |
|
| hsa-miR-590-3p |
gaattattTAAAATTAgta |
0 | UAAUUUUA | m8a | Created | 0.336 | 0.442 |
-0.51 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr12:g.72664863C>A | COSN14835767 | LP6005334-DNA_C03 | [oesophagus][NS][carcinoma][adenocarcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-323a-5p |
aaagtACCACCTaaaactg |
0 | AGGUGGUC | m7a | Disrupted | NA | NA |
1.370000 |
|
| hsa-miR-4259 |
aaagtaCCAACTaaaactg |
0 | CAGUUGGG | m6b | Created | no TS | -0.097000 |
-3.790000 |
|
| hsa-miR-4715-5p |
aaagtaCCAACTaaaactg |
0 | AAGUUGGC | m6b | Created | no TS | -0.120000 |
-0.460000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr12:g.72665351C>G | COSN8586664 | 1409_T | [lung][NS][carcinoma][squamous_cell_carcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-3922-5p |
tttagtGGCCTTGAacaac |
14 |
UCAAGGCC | m8a | Disrupted | -0.431000 | no TS |
3.230000 |
|
| hsa-miR-4717-5p |
tttaGTGGCCTtgaacaac |
15 |
UAGGCCAC | m7b | Disrupted | -0.318000 | no TS |
0.170000 |
|
| hsa-miR-4753-5p |
tttagTGGCCTTGaacaac |
15 |
CAAGGCCA | m8a | Disrupted | -0.217000 | no TS |
0.710000 |
|
| hsa-miR-561-5p |
tttagtggCCTTGAacaac |
9 |
AUCAAGGA | m6b | Disrupted | -0.113000 | no TS | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr12:g.72665409T>A | COSN5952095 | RK308_C01 | [liver][NS][carcinoma][NS] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-let-7a-2-3p |
gtgcaaTGTACAatacctc |
12 |
CUGUACAG | m6b | Created | -0.198000 | -0.282000 | No effect |
| hsa-let-7g-3p |
gtgcaaTGTACAatacctc |
12 |
CUGUACAG | m6b | Created | -0.206000 | -0.290000 |
-0.080000 |
| hsa-miR-493-5p |
gtgcaATGTACAAtacctc |
13 |
UUGUACAU | m8a | Created | -0.170000 | -0.417000 |
-0.020000 |
| Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
|---|---|---|---|---|---|---|---|---|---|
| 72663247 | rs73316872 | C | C |
hsa-miR-187-3p hsa-miR-4711-3p |
1 2 |
aAGACACGctttt AAGACACgctttt |
Disrupted Disrupted |
N N |
-0.295 -0.156 |
| T |
hsa-miR-4422 hsa-miR-548e-5p |
1 1 |
aagacATGCTTTt aagacaTGCTTTT |
Created Created |
N N |
-0.097 -0.09 |
|||
| 72663701 | rs73316874 | C | T |
hsa-miR-382-3p |
2 |
cagaAATGATAtt |
Created |
N |
-0.003 |
| 72664037 | rs77522743 | C | C |
hsa-miR-1258 hsa-miR-32-3p |
1 5 |
TCCTAACtaaatt tcctaaCTAAATT |
Disrupted Disrupted |
N N |
-0.146 0.024 |
| G |
hsa-miR-374c-3p hsa-miR-4699-3p |
1 5 |
tcCTAAGTAaatt tcctaAGTAAATt |
Created Created |
N N |
-0.059 -0.012 |
|||
| 72664758 | rs141366738 | A | A |
hsa-miR-148a-3p hsa-miR-148b-3p hsa-miR-152-3p hsa-miR-4276 |
1 1 1 5 |
gtacGCACTGAat gtacGCACTGAat gtacGCACTGAat gtacgCACTGAAt |
Disrupted Disrupted Disrupted Disrupted |
N N N N |
-0.129 -0.129 -0.129 -0.063 |
| 72665010 | rs183769243 | C | C |
hsa-miR-561-3p |
2 |
tctAAACTTTttc |
Disrupted |
N |
-0.049 |
| G |
hsa-miR-548ae hsa-miR-548ah-3p hsa-miR-548aj-3p hsa-miR-548am-3p hsa-miR-548aq-3p hsa-miR-548j-3p hsa-miR-548x-3p hsa-miR-5582-3p |
2 2 2 2 2 2 2 2 |
tctaaAGTTTTTc tctaaAGTTTTTc tctaaAGTTTTTc tctaaAGTTTTTc tctaaAGTTTTTc tctaaAGTTTTTc tctaaAGTTTTTc tctaAAGTTTTtc |
Created Created Created Created Created Created Created Created |
N N N N N N N N |
-0.022 -0.022 -0.022 -0.022 -0.022 -0.022 -0.022 -0.018 |
|||
| 72665262 | rs58439542 | A | A |
hsa-miR-224-3p hsa-miR-5093 hsa-miR-522-3p |
7 4 7 |
attACCATTTcca attacCATTTCCA attACCATTTcca |
Disrupted Disrupted Disrupted |
N N N |
-0.12 -0.189 -0.158 |
| G |
hsa-miR-4261 hsa-miR-553 |
4 7 |
attaccGTTTCCA attACCGTTTcca |
Created Created |
N N |
-0.074 -0.291 |