SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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RefSeq ID: | NM_139075 |
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Gene Symbol: | TPCN2 |
Description: | Homo sapiens two pore segment channel 2 (TPCN2), mRNA. |
Gene Location: | chr11(+):68816349-68858072 |
Browse Associations |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr11:g.69088015G>A | COSN6611091 | CHC205T | [liver][NS][carcinoma][hepatocellular_carcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr11:g.69088709T>C | COSN8536472 | tumor_4166706 | [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr11:g.69088934C>T | COSN15290102 | 0064_CRUK_PC_0064_T1_DNA | [prostate][NS][carcinoma][adenocarcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-204-3p |
agcaacTCCCAGaaacaac |
1 |
GCUGGGAA | m6b | Disrupted | -0.048000 | no TS |
0.030000 |
|
hsa-miR-30b-3p |
agcaaCTCCCAGaaacaac |
2 |
CUGGGAGG | m7a | Disrupted | -0.111000 | -0.111000 | No effect | |
hsa-miR-30c-1-3p |
agcaaCTCCCAGaaacaac |
0 | CUGGGAGA | m7a | Disrupted | NA | NA |
0.010000 |
|
hsa-miR-30c-2-3p |
agcaaCTCCCAGaaacaac |
0 | CUGGGAGA | m7a | Disrupted | NA | NA |
0.040000 |
|
hsa-miR-3192 |
agcaaCTCCCAGAaacaac |
4 |
UCUGGGAG | m8a | Disrupted | -0.179000 | -0.018000 | No effect | |
hsa-miR-3689a-3p |
agcaaCTCCCAGaaacaac |
2 |
CUGGGAGG | m7a | Disrupted | -0.120000 | -0.120000 | No effect | |
hsa-miR-3689b-3p |
agcaaCTCCCAGaaacaac |
2 |
CUGGGAGG | m7a | Disrupted | -0.120000 | -0.120000 | No effect | |
hsa-miR-3689c |
agcaaCTCCCAGaaacaac |
2 |
CUGGGAGG | m7a | Disrupted | -0.120000 | -0.120000 | No effect | |
hsa-miR-4266 |
agcaaCTCCTAGaaacaac |
0 | CUAGGAGG | m7a | Created | NA | NA | No effect | |
hsa-miR-4314 |
agcaacTCCCAGAaacaac |
1 |
CUCUGGGA | m7b | Disrupted | -0.120000 | no TS |
1.410000 |
|
hsa-miR-4646-5p |
agcaacTCCCAGaaacaac |
1 |
ACUGGGAA | m6b | Disrupted | -0.052000 | no TS |
0.010000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr11:g.69090412G>A | COSN1136984 | HCC116T | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-4264 |
atccGACTGAGgctttgac |
0 | ACUCAGUC | m7b | Created | no TS | -0.096000 | No effect | |
hsa-miR-4323 |
atccgacTGGGGCTttgac |
2 |
CAGCCCCA | m7b | Disrupted | -0.187000 | no TS | No effect | |
hsa-miR-4264 |
atccGACTGAGgctttgac |
0 | ACUCAGUC | m7b | Created | no TS | -0.096 | No effect | |
hsa-miR-4323 |
atccgacTGGGGCTttgac |
2 |
CAGCCCCA | m7b | Disrupted | -0.187 | no TS | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr11:g.69090422T>A | COSN1136985 | HCC116T | [liver][NS][carcinoma][NS] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-4294 |
ggctttGACTCCCacactg |
5 |
GGGAGUCU | m7a | Disrupted | -0.141000 | -0.141000 |
1.040000 |
hsa-miR-4455 |
ggctttgACACCCacactg |
0 | AGGGUGUG | m6b | Created | no TS | -0.125000 |
1.180000 |
hsa-miR-4769-5p |
ggctttgacTCCCACactg |
2 |
GGUGGGAU | m6b | Disrupted | -0.144000 | no TS | No effect |
hsa-miR-609 |
ggctttgACACCCacactg |
0 | AGGGUGUU | m6b | Created | no TS | -0.151000 |
-6.230000 |
hsa-miR-4294 |
ggctttGACTCCCacactg |
0 | GGGAGUCU | m7a | Disrupted | -0.141 | -0.141 |
1.04 |
hsa-miR-4455 |
ggctttgACACCCacactg |
0 | AGGGUGUG | m6b | Created | no TS | -0.125 |
1.18 |
hsa-miR-4769-5p |
ggctttgacTCCCACactg |
0 | GGUGGGAU | m6b | Disrupted | -0.144 | no TS | No effect |
hsa-miR-609 |
ggctttgACACCCacactg |
0 | AGGGUGUU | m6b | Created | no TS | -0.151 |
-6.23 |
Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
---|---|---|---|---|---|---|---|---|---|
69090407 | rs149957892 | G | G |
hsa-miR-105-3p |
0 |
tCATCCGActggg |
Disrupted |
N |
-0.179 |
C |
hsa-miR-194-3p hsa-miR-4654 hsa-miR-4769-5p hsa-miR-5187-5p hsa-miR-6728-5p |
0 |
tcatCCCACTGgg tcATCCCACtggg tcATCCCACtggg TCATCCCActggg tCATCCCActggg |
Created Created Created Created Created |
N N N N N |
-0.165 -0.163 -0.107 -0.232 -0.129 |
|||
69090428 | rs11228488 | A | A |
hsa-miR-1233-5p hsa-miR-128-3p hsa-miR-216a-3p hsa-miR-3681-3p hsa-miR-4302 hsa-miR-4648 hsa-miR-4654 hsa-miR-4769-5p hsa-miR-6778-5p |
2 2 2 2 2 2 2 2 2 |
TCCCACActgtgt tcccaCACTGTGt tcccaCACTGTGt tcccaCACTGTGt tccCACACTGtgt TCCCACActgtgt TCCCACActgtgt TCCCACActgtgt TCCCACActgtgt |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N N N |
-0.168 -0.138 -0.129 -0.119 -0.089 -0.151 -0.144 -0.144 -0.168 |
T |
hsa-miR-4481 hsa-miR-4745-5p hsa-miR-4797-5p hsa-miR-759 |
2 2 2 2 |
tCCCACTCtgtgt tCCCACTCtgtgt tcccACTCTGTgt tccCACTCTGtgt |
Created Created Created Created |
N N N N |
-0.197 -0.188 -0.021 -0.111 |