SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_139075
Gene Symbol: TPCN2
Description: Homo sapiens two pore segment channel 2 (TPCN2), mRNA.
Gene Location: chr11(+):68816349-68858072
Browse Associations

Somatic mutations that impact miRNA target sites




Mutation Mutation ID Sample Name Cancer Type
chr11:g.69088015G>A COSN6611091 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Mutation Mutation ID Sample Name Cancer Type
chr11:g.69088709T>C COSN8536472 tumor_4166706 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr11:g.69088934C>T COSN15290102 0064_CRUK_PC_0064_T1_DNA [prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-204-3p agcaacTCCCAGaaacaac
1
GCUGGGAA m6b Disrupted -0.048000 no TS 0.030000
hsa-miR-30b-3p agcaaCTCCCAGaaacaac
2
CUGGGAGG m7a Disrupted -0.111000 -0.111000 No effect
hsa-miR-30c-1-3p agcaaCTCCCAGaaacaac
0 CUGGGAGA m7a Disrupted NA NA 0.010000
hsa-miR-30c-2-3p agcaaCTCCCAGaaacaac
0 CUGGGAGA m7a Disrupted NA NA 0.040000
hsa-miR-3192 agcaaCTCCCAGAaacaac
4
UCUGGGAG m8a Disrupted -0.179000 -0.018000 No effect
hsa-miR-3689a-3p agcaaCTCCCAGaaacaac
2
CUGGGAGG m7a Disrupted -0.120000 -0.120000 No effect
hsa-miR-3689b-3p agcaaCTCCCAGaaacaac
2
CUGGGAGG m7a Disrupted -0.120000 -0.120000 No effect
hsa-miR-3689c agcaaCTCCCAGaaacaac
2
CUGGGAGG m7a Disrupted -0.120000 -0.120000 No effect
hsa-miR-4266 agcaaCTCCTAGaaacaac
0 CUAGGAGG m7a Created NA NA No effect
hsa-miR-4314 agcaacTCCCAGAaacaac
1
CUCUGGGA m7b Disrupted -0.120000 no TS 1.410000
hsa-miR-4646-5p agcaacTCCCAGaaacaac
1
ACUGGGAA m6b Disrupted -0.052000 no TS 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr11:g.69090412G>A COSN1136984 HCC116T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4264 atccGACTGAGgctttgac
0 ACUCAGUC m7b Created no TS -0.096000 No effect
hsa-miR-4323 atccgacTGGGGCTttgac
2
CAGCCCCA m7b Disrupted -0.187000 no TS No effect
hsa-miR-4264 atccGACTGAGgctttgac
0 ACUCAGUC m7b Created no TS -0.096 No effect
hsa-miR-4323 atccgacTGGGGCTttgac
2
CAGCCCCA m7b Disrupted -0.187 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr11:g.69090422T>A COSN1136985 HCC116T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4294 ggctttGACTCCCacactg
5
GGGAGUCU m7a Disrupted -0.141000 -0.141000 1.040000
hsa-miR-4455 ggctttgACACCCacactg
0 AGGGUGUG m6b Created no TS -0.125000 1.180000
hsa-miR-4769-5p ggctttgacTCCCACactg
2
GGUGGGAU m6b Disrupted -0.144000 no TS No effect
hsa-miR-609 ggctttgACACCCacactg
0 AGGGUGUU m6b Created no TS -0.151000 -6.230000
hsa-miR-4294 ggctttGACTCCCacactg
0 GGGAGUCU m7a Disrupted -0.141 -0.141 1.04
hsa-miR-4455 ggctttgACACCCacactg
0 AGGGUGUG m6b Created no TS -0.125 1.18
hsa-miR-4769-5p ggctttgacTCCCACactg
0 GGUGGGAU m6b Disrupted -0.144 no TS No effect
hsa-miR-609 ggctttgACACCCacactg
0 AGGGUGUU m6b Created no TS -0.151 -6.23

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
69090407 rs149957892 G G hsa-miR-105-3p
0 tCATCCGActggg
Disrupted
N
-0.179
C hsa-miR-194-3p
hsa-miR-4654
hsa-miR-4769-5p
hsa-miR-5187-5p
hsa-miR-6728-5p
0 tcatCCCACTGgg
tcATCCCACtggg
tcATCCCACtggg
TCATCCCActggg
tCATCCCActggg
Created
Created
Created
Created
Created
N
N
N
N
N
-0.165
-0.163
-0.107
-0.232
-0.129
69090428 rs11228488 A A hsa-miR-1233-5p
hsa-miR-128-3p
hsa-miR-216a-3p
hsa-miR-3681-3p
hsa-miR-4302
hsa-miR-4648
hsa-miR-4654
hsa-miR-4769-5p
hsa-miR-6778-5p
2
2
2
2
2
2
2
2
2
TCCCACActgtgt
tcccaCACTGTGt
tcccaCACTGTGt
tcccaCACTGTGt
tccCACACTGtgt
TCCCACActgtgt
TCCCACActgtgt
TCCCACActgtgt
TCCCACActgtgt
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
N
-0.168
-0.138
-0.129
-0.119
-0.089
-0.151
-0.144
-0.144
-0.168
T hsa-miR-4481
hsa-miR-4745-5p
hsa-miR-4797-5p
hsa-miR-759
2
2
2
2
tCCCACTCtgtgt
tCCCACTCtgtgt
tcccACTCTGTgt
tccCACTCTGtgt
Created
Created
Created
Created
N
N
N
N
-0.197
-0.188
-0.021
-0.111

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