| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
||||||||
| Home | Search | Help | Download | |||||
| RefSeq ID: | NM_001204189 |
|---|---|
| Gene Symbol: | TP73 |
| Description: | Homo sapiens tumor protein p73 (TP73), transcript variant 2, mRNA. |
| Gene Location: | chr1(+):3607235-3652765 |
| Browse Associations | |
| Browse Pathways | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr1:g.3733327G>T | COSN1103580 | BN02T | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-3943 |
ttgtggggcGGGGGCTggc |
0 | UAGCCCCC | m7b | (m7b->m6c) | -0.363000 | -0.269000 | No effect | |
| hsa-miR-4323 |
ttgtggggcTGGGGCTGgc |
0 | CAGCCCCA | m8a | (m7b->m8a) | no TS | -0.120000 |
-0.120000 |
|
| hsa-miR-3943 |
ttgtggggcGGGGGCTggc |
0 | UAGCCCCC | m7b | (m7b->m6c) | -0.363 | -0.269 | No effect | |
| hsa-miR-4323 |
ttgtggggcTGGGGCTGgc |
0 | CAGCCCCA | m8a | (m7b->m8a) | no TS | -0.12 |
-0.12 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr1:g.3734201G>A | COSN10047886 | C0004T | [kidney][NS][other][neoplasm] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-4732-3p |
gcggtggcaGTCAGGGaac |
2 |
GCCCUGAC | m7b | (m7b->m6c) | -0.163000 | -0.098000 |
0.290000 |
|
| hsa-miR-5002-3p |
gcggtGGCAGTCAgggaac |
2 |
UGACUGCC | m8a | Disrupted | -0.065000 | no TS |
0.070000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr1:g.3734741C>T | COSN7218293 | 8031704 | [pancreas][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-376a-3p |
cctggTCTATGAagacgca |
0 | AUCAUAGA | m7b | Created | no TS | 0.193000 | No effect | |
| hsa-miR-376b |
cctggTCTATGAagacgca |
0 | AUCAUAGA | m7b | Created | no TS | 0.193000 | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr1:g.3735047A>C | COSN8468010 | AOCS-034-3-8 | [ovary][NS][other][neoplasm] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-miR-185-3p |
ggcgCAGCCCCcccagctg |
0 | AGGGGCUG | m7b | Created | -0.063000 | -0.051000 |
-0.030000 |
| hsa-miR-342-5p |
ggcgcagcCACCCCagctg |
2 |
AGGGGUGC | m6b | Disrupted | -0.102000 | -0.077000 | No effect |
| hsa-miR-4483 |
ggcgcagCCACCCCagctg |
0 | GGGGUGGU | m7a | Disrupted | 0.004000 | 0.004000 | No effect |
| hsa-miR-4651 |
ggcgcagCCACCCCagctg |
0 | CGGGGUGG | m7b | Disrupted | -0.055000 | 0.020000 | No effect |
| hsa-miR-608 |
ggcgcagCCACCCCagctg |
0 | AGGGGUGG | m7b | Disrupted | -0.069000 | 0.017000 | No effect |
| hsa-miR-637 |
ggcgcagccCCCCCAGctg |
2 |
ACUGGGGG | m7b | (m6c->m7b) | -0.263000 | -0.262000 | No effect |
| hsa-miR-647 |
ggcGCAGCCACcccagctg |
0 | GUGGCUGC | m8a | Disrupted | -0.360000 | -0.395000 | No effect |
| Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
|---|---|---|---|---|---|---|---|---|---|
| 3733753 | rs74489056 | C | C |
hsa-miR-328-5p hsa-miR-637 hsa-miR-661 hsa-miR-6795-5p hsa-miR-6852-5p hsa-miR-6885-5p hsa-miR-6887-5p hsa-miR-7109-5p |
0 |
accCCCCCCAggc acccCCCCCAGgc acccccCCCAGGC accCCCCCCAggc accccCCCCAGGc accCCCCCCAggc accCCCCCCAggc accCCCCCCAggc |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N N |
-0.092 0.016 0.031 -0.092 0.043 -0.109 -0.095 -0.043 |
| A |
hsa-miR-4447 hsa-miR-4456 hsa-miR-4472 hsa-miR-541-3p hsa-miR-654-5p hsa-miR-6751-5p hsa-miR-6752-5p hsa-miR-6769a-5p hsa-miR-6769b-5p hsa-miR-6803-5p hsa-miR-6835-5p hsa-miR-6842-5p hsa-miR-7110-5p hsa-miR-92a-2-5p |
0 |
aCCCCCACcaggc acccCCACCAGgc aCCCCCACcaggc accCCCACCAggc accCCCACCAggc ACCCCCAccaggc ACCCCCAccaggc accCCCACCAggc accCCCACCAggc ACCCCCAccaggc ACCCCCAccaggc ACCCCCAccaggc ACCCCCAccaggc acCCCCACCAggc |
Created Created Created Created Created Created Created Created Created Created Created Created Created Created |
N N N N N N N N N N N N N N |
-0.078 0.043 -0.078 -0.023 -0.019 -0.004 -0.044 -0.029 -0.022 -0.031 -0.044 -0.037 -0.03 -0.148 |
|||
| 3734643 | rs76363456 | T | T |
hsa-miR-4450 hsa-miR-4667-5p hsa-miR-4700-5p hsa-miR-6857-5p hsa-miR-8089 |
4 3 3 4 3 |
cccccATCCCCAg cccccaTCCCCAG cccccaTCCCCAG cccccATCCCCAg cccccaTCCCCAG |
Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N |
0.01 -0.027 -0.035 0.086 -0.041 |
| C |
hsa-miR-4447 hsa-miR-4472 hsa-miR-4651 hsa-miR-608 hsa-miR-637 hsa-miR-6751-5p hsa-miR-6752-5p hsa-miR-6756-5p hsa-miR-6766-5p hsa-miR-6803-5p hsa-miR-6835-5p hsa-miR-6842-5p hsa-miR-7110-5p hsa-miR-92a-2-5p |
3 3 3 3 3 4 3 3 3 4 4 3 3 3 |
CCCCCACccccag CCCCCACccccag cccCCACCCCcag cccCCACCCCcag cccccaCCCCCAG cccccACCCCCAg ccccCACCCCCAg ccCCCACCCccag ccCCCACCCccag cccccACCCCCAg cccccACCCCCAg ccccCACCCCCAg ccccCACCCCCAg cCCCCACCcccag |
Created Created Created Created Created Created Created Created Created Created Created Created Created Created |
N N N N N N N N N N N N N N |
0.002 0.002 0.005 0.024 -0.105 0.01 -0.044 0.042 0.032 -0.037 -0.034 -0.044 -0.055 0.032 |
|||
| 3734712 | rs189037405 | G | G |
hsa-miR-639 |
2 |
aGCAGCGActggt |
Disrupted |
N |
-0.134 |
| C |
hsa-miR-5693 hsa-miR-604 hsa-miR-647 hsa-miR-6762-3p |
2 2 2 2 |
agcaGCCACTGgt aGCAGCCActggt aGCAGCCActggt AGCAGCCActggt |
Created Created Created Created |
N N N N |
-0.038 -0.058 -0.048 -0.095 |