SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
  Home Search Help Download  

PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_001114981
Gene Symbol: TP63
Description: Homo sapiens tumor protein p63 (TP63), transcript variant 2, mRNA.
Gene Location: chr3(+):189507448-189615068
Browse Associations

Somatic mutations that impact miRNA target sites




Mutation Mutation ID Sample Name Cancer Type
chr3:g.189894239C>T ICGC_1321265 TCGA-AP-A0LM-01A-11D-A122-09 UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr3:g.189894246C>T ICGC_1321267 TCGA-B5-A11G-01A-13D-A122-09 UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4717-3p ttcgaCATGTGatctggaa
0 ACACAUGG m6b Created -0.423 -0.517 -0.13

Mutation Mutation ID Sample Name Cancer Type
chr3:g.189894247G>A ICGC_1321268 TCGA-D1-A17Q-01A-11D-A12J-09 UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4666b tcgACATGCAAtctggaag
0 UUGCAUGU m8a Created -0.402 -0.734 -2.03
hsa-miR-5011-3p tcgaCATGCAatctggaag
0 GUGCAUGG m6b Created -0.259 -0.386 -0.1

Mutation Mutation ID Sample Name Cancer Type
chr3:g.189894368C>T ICGC_1321269 TCGA-AP-A051-01A-21W-A027-09 UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-329 cggggtgaGTGTGTTattg
0 AACACACC m7a Created -0.049 -0.049 -0.02
hsa-miR-362-3p cggggtgaGTGTGTTattg
0 AACACACC m7a Created -0.059 -0.059 -0.02
hsa-miR-574-3p cggggTGAGCGTGttattg
0 CACGCUCA m8a Disrupted -0.199 no TS 1.74
hsa-miR-603 cggggtgAGTGTGTtattg
0 CACACACU m7b Created -0.144 -0.228 No effect

Mutation Mutation ID Sample Name Cancer Type
chr3:g.189894498A>G ICGC_sm392255 RK099_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4640-3p aggaggGGGGGTGagcctc
0 CACCCCCU m7a Created NA NA 2.81


Mutation Mutation ID Sample Name Cancer Type
chr3:g.189894871G>A COSN5147635 PD4107a [breast][NS][carcinoma][ductal_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr3:g.189896146C>T COSN6573408 ICGC_MB110 [central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4780 cattctggTCAAGGGctgt
2
ACCCUUGA m7b Disrupted -0.025000 no TS 0.780000
hsa-miR-938 cattctggtTAAGGGCtgt
0 UGCCCUUA m7b (m6c->m7b) -0.158000 -0.266000 -2.510000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.189896203C>T COSN1937742 RK052_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-193a-3p aagGGCCAGTgtggctcta
0 AACUGGCC m7b (m6b->m7b) no TS -0.083000 -0.010000
hsa-miR-193b-3p aagGGCCAGTgtggctcta
0 AACUGGCC m7b (m6b->m7b) no TS -0.102000 No effect
hsa-miR-449b-3p aagggccagTGTGGCTcta
0 CAGCCACA m7b (m6c->m7b) no TS -0.097000 -2.410000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.189896847C>T COSN1937743 RK141_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-140-5p tagaAACCACTagaaagtg
2
CAGUGGUU m7b Disrupted -0.355000 -0.060000 0.210000
hsa-miR-4263 tagaaaccaTTAGAAagtg
0 AUUCUAAG m6b Created no TS 0.050000 -0.640000
hsa-miR-4460 tagaaACCACTAgaaagtg
2
AUAGUGGU m7b Disrupted -0.205000 no TS 0.340000
hsa-miR-576-5p tagaaaccATTAGAAagtg
0 AUUCUAAU m7b Created no TS 0.022000 -0.240000
hsa-miR-140-5p tagaAACCACTagaaagtg
2
CAGUGGUU m7b Disrupted -0.355 -0.06 0.21
hsa-miR-4263 tagaaaccaTTAGAAagtg
0 AUUCUAAG m6b Created no TS 0.05 -0.64
hsa-miR-4460 tagaaACCACTAgaaagtg
2
AUAGUGGU m7b Disrupted -0.205 no TS 0.34
hsa-miR-576-5p tagaaaccATTAGAAagtg
0 AUUCUAAU m7b Created no TS 0.022 -0.24

Mutation Mutation ID Sample Name Cancer Type
chr3:g.189897094A>G COSN5531014 RK125_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1323 aaaAGTTTTGtatgcttta
3
UCAAAACU m7b (m6b->m7b) -0.058000 -0.262000 -0.080000
hsa-miR-548o-3p aaaAGTTTTGtatgcttta
3
CCAAAACU m7b (m6b->m7b) -0.040000 -0.226000 -3.020000
hsa-miR-5582-3p aaAAGTTTTAtatgcttta
8
UAAAACUU m8a (m8a->m7a) 0.065000 0.142000 No effect
hsa-miR-5689 aaaagtttTGTATGCTtta
0 AGCAUACA m8a Created no TS -0.298000 -0.020000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
189894247 rs148577576 G
A hsa-miR-4666b
hsa-miR-5011-3p
1
1
ACATGCAAtctgg
aCATGCAAtctgg
Created
Created
N
N
-0.332
-0.127
189896102 rs35896507 G G hsa-miR-1468-3p
hsa-miR-3613-3p
hsa-miR-548aj-5p
hsa-miR-548aw
hsa-miR-548f-5p
hsa-miR-548g-5p
hsa-miR-548x-5p
2
2
2
2
2
2
2
ttTTTTGCAtgca
TTTTTTGcatgca
ttTTTTGCAtgca
ttTTTTGCAtgca
ttTTTTGCAtgca
ttTTTTGCAtgca
ttTTTTGCAtgca
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
0.055
0.137
0.059
0.023
0.062
0.059
0.059
C hsa-miR-3148
hsa-miR-3688-3p
hsa-miR-5011-3p
hsa-miR-6124
2
2
2
2
tTTTTTCCAtgca
tttTTTCCATgca
ttttttCCATGCA
ttTTTTCCAtgca
Created
Created
Created
Created
N
N
N
N
0.042
0.009
-0.136
0.078
189896415 rs181220329 A A hsa-miR-4282
15
gctacAATTTTAa
Disrupted
N
0.157
G hsa-miR-1183
hsa-miR-3137
hsa-miR-548a-3p
hsa-miR-548ar-3p
hsa-miR-548az-3p
hsa-miR-548e-3p
hsa-miR-548f-3p
hsa-miR-548g-3p
hsa-miR-5582-3p
2
2
2
2
2
2
2
2
3
gCTACAGTtttaa
GCTACAGttttaa
gctaCAGTTTTAa
gctaCAGTTTTAa
gctaCAGTTTTAa
gctaCAGTTTTAa
gctaCAGTTTTAa
gctACAGTTTtaa
gctacAGTTTTAa
Created
Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
N
-0.093
-0.185
-0.022
-0.053
0.01
0.01
-0.011
-0.047
0.092
189896441 rs140654135 - T hsa-miR-548ae
hsa-miR-548ah-3p
hsa-miR-548aj-3p
hsa-miR-548am-3p
hsa-miR-548aq-3p
hsa-miR-548j-3p
hsa-miR-548x-3p
hsa-miR-5582-3p
1
1
1
1
1
1
1
1
ggaaAGTTTTTtt
ggaaAGTTTTTtt
ggaaAGTTTTTtt
ggaaAGTTTTTtt
ggaaAGTTTTTtt
ggaaAGTTTTTtt
ggaaAGTTTTTtt
ggaAAGTTTTttt
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
N
N
N
N
N
N
N
N
No Change
No Change
No Change
No Change
No Change
No Change
No Change
0.001
-
189896504 rs35969817 T T hsa-miR-1323
hsa-miR-3065-5p
hsa-miR-548o-3p
hsa-miR-5582-3p
3
4
3
9
caaAGTTTTGttg
caaagtTTTGTTG
caaAGTTTTGttg
caAAGTTTTgttg
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
-0.058
-0.073
-0.04
0.039

Genome Browser