SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001114979
Gene Symbol:	TP63
Description:	Homo sapiens tumor protein p63 (TP63), transcript variant 2, mRNA.
Gene Location:	chr3(+):189349215-189599284
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.189880247A>G			ICGC_7453E9F4-2A78-11E2-96E7-04FD496BB9B8		CPCG_0102_Pr_P_P1		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3941	tgtGTGTGTAtgtgtgtgc	0	UUACACAC	m7b	(m7b->m6b)	-0.249	-0.078	0.28
hsa-miR-4789-3p	tgtgtgtgTATGTGTGtgc	0	CACACAUA	m8a	Disrupted	-0.113	-0.072	-0.55

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.189880257G>A			COSN14936836		LP6007544-DNA_A01		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-329	tgtgtgtgcGTGTGTatct	0	AACACACC	m6b	Disrupted	-0.211000	-0.109000	-0.070000
hsa-miR-362-3p	tgtgtgtgcGTGTGTatct	0	AACACACC	m6b	Disrupted	-0.211000	-0.109000	-0.070000
hsa-miR-3941	tgtgtgtgcGTGTGTAtct	0	UUACACAC	m7b	(m7b->m6c)	-0.249000	-0.162000	-0.090000
hsa-miR-4643	tgtgtgtgCATGTGTatct	1	GACACAUG	m7b	Created	-0.412000	-0.660000	0.190000
hsa-miR-466	tgtgtgtgcATGTGTATct	1	AUACACAU	m8a	(m7b->m8a)	-0.184000	-0.269000	0.270000
hsa-miR-4717-3p	tgtgtgtgCATGTGTatct	5	ACACAUGG	m7a	Created	-0.247000	-0.247000	0.010000
hsa-miR-4789-3p	tgtgtgtgcATGTGTatct	1	CACACAUA	m6b	Created	-0.113000	-0.179000	-0.300000
hsa-miR-603	tgtgtgtgcGTGTGTatct	6	CACACACU	m6b	Disrupted	-0.606000	-0.508000	-0.030000

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.189881130A>G			COSN1937736		RK048_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-5579-5p	ctaccTACCATAaaaccag	6	UAUGGUAC	m7a	Disrupted	-0.087000	no TS	6.620000
hsa-miR-584-5p	ctacctACCATAAaaccag	6	UUAUGGUU	m7a	Disrupted	-0.071000	no TS	3.460000
hsa-miR-5579-5p	ctaccTACCATAaaaccag	6	UAUGGUAC	m7a	Disrupted	-0.087000	no TS	6.620000
hsa-miR-584-5p	ctacctACCATAAaaccag	6	UUAUGGUU	m7a	Disrupted	-0.071000	no TS	3.460000
hsa-miR-5579-5p	ctaccTACCATAaaaccag	6	UAUGGUAC	m7a	Disrupted	-0.087	no TS	6.62
hsa-miR-584-5p	ctacctACCATAAaaccag	6	UUAUGGUU	m7a	Disrupted	-0.071	no TS	3.46

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
189880217	rs148731783	-	-	hsa-miR-3688-3p hsa-miR-4717-3p hsa-miR-4802-3p hsa-miR-5093	21 21 21 3	gtaTTTCCATgtg gtatttCCATGTG gtattTCCATGTg gtATTTCCAtgtg	Unknown Unknown Unknown Unknown	N N N N	-0.145 -0.05 -0.27 -0.051
			C	hsa-miR-3153 hsa-miR-4668-5p hsa-miR-6733-5p hsa-miR-6739-5p	21 21 21 21	gtaTTTCCCAtgtg gtaTTTCCCAtgtg gtaTTTCCCAtgtg gtaTTTCCCAtgtg	Unknown Unknown Unknown Unknown	N N N N	-0.109 -0.107 -0.115 -0.112
189880233	rs147985284	-	GT	hsa-miR-603	20	tatgtgAGTGTGTgt	Unknown	N	No Change
			-
189880249	rs35477020	G	G	hsa-miR-4789-3p	1	gtgTATGTGTgtg	Disrupted	N	0.044
			A	hsa-miR-4789-5p	1	GTGTATAtgtgtg	Created	N	-0.079

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