SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001126112
Gene Symbol: TP53
Description: Homo sapiens tumor protein p53 (TP53), transcript variant 1, mRNA.
Gene Location: chr17(-):7571719-7590863
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Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr17:g.7668450C>T 0_24 Melanoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr17:g.7668716C>T COSN4770634 tumor_4191799 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-5690 ccggaGTAGCTGggaccac
 2
 UCAGCUAC m7b Disrupted -0.068000 no TS 1.810000
hsa-miR-606 ccggAGTAGTTgggaccac
 0 AAACUACU m7b Created no TS 0.053000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr17:g.7668750G>A cosmic_v64_1760522 Leukemia/T-ALL
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3150a-3p tgcCTCCCCAGctcgagca
 0 CUGGGGAG m8a Created no TS -0.078 -0.01
hsa-miR-4487 tgcctccCCAGCTCgagca
 0 AGAGCUGG m7b Created no TS -0.107 -2.8
hsa-miR-4667-5p tgccTCCCCAGctcgagca
 0 ACUGGGGA m7b Created no TS -0.129 -0.1
hsa-miR-4700-5p tgccTCCCCAGctcgagca
 0 UCUGGGGA m7b Created no TS -0.082 -2.8
hsa-miR-4731-5p tgcctCCCCAGCtcgagca
 0 UGCUGGGG m7b Created no TS -0.163 -1.92

Mutation Mutation ID Sample Name Cancer Type
chr17:g.7668837T>C 9_79159 CRC-7-Tumor Colorectal adenocarcinoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3148 ttttTTTTTCCtttttctt
 1
 UGGAAAAA m7b Created no TS -0.083 -1.23

Mutation Mutation ID Sample Name Cancer Type
chr17:g.7669200C>A COSN6661031 CHC433T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-196a-5p gcatttgcaACTACCTcac
 0 UAGGUAGU m7b (m6b->m7b) no TS -0.167000 -2.050000
hsa-miR-196b-5p gcatttgcaACTACCTcac
 0 UAGGUAGU m7b (m6b->m7b) no TS -0.157000 -1.710000
hsa-miR-19a-3p gcaTTTGCACctacctcac
 2
 UGUGCAAA m7b (m7b->m6c) -0.107000 no TS 1.770000
hsa-miR-19b-3p gcaTTTGCACctacctcac
 2
 UGUGCAAA m7b (m7b->m6c) -0.107000 no TS 2.340000
hsa-miR-4684-3p gcatTTGCAACtacctcac
 0 UGUUGCAA m7b Created no TS -0.128000 -0.060000
hsa-miR-4703-3p gcatttgCAACTACctcac
 0 UGUAGUUG m7b Created no TS -0.089000 -0.470000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
7669200 rs191918079 C C hsa-miR-19a-3p
hsa-miR-19b-3p
2
2
 TTTGCACctacct
TTTGCACctacct
 Disrupted
Disrupted
N
N
 -0.107
-0.107
A hsa-miR-196a-5p
hsa-miR-196b-5p
hsa-miR-4684-3p
hsa-miR-4703-3p
hsa-miR-518a-5p
hsa-miR-527
hsa-miR-548aw
10
10
2
2
2
2
2
 tttgcaACTACCT
tttgcaACTACCT
tTTGCAACtacct
tttgCAACTACct
TTTGCAActacct
TTTGCAActacct
TTTGCAActacct
 Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
 -0.167
-0.157
-0.128
-0.089
0.005
0.005
0.012

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