| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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| RefSeq ID: | NM_001098797 |
|---|---|
| Gene Symbol: | TOX2 |
| Description: | Homo sapiens TOX high mobility group box family member 2 (TOX2), transcript variant 4, mRNA. |
| Gene Location: | chr20(+):42543491-42698254 |
| Browse Associations | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr20:g.44068717T>G | ICGC_1446312 | TCGA-BS-A0UV-01A-11D-A10B-09 | UterineCorpusEndometrioidCarcinoma(TCGA,US) | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1471 |
gaggctCGCGGGaaggcac |
0 | GCCCGCGU | m6b | Created | no TS | -0.303 |
-2.63 |
|
| hsa-miR-4738-5p |
gaggctCGCTGGaaggcac |
5 |
ACCAGCGC | m6b | Disrupted | -0.226 | no TS |
9.76 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr20:g.44068808C>T | ICGC_1446313 | TCGA-BS-A0UV-01A-11D-A10B-09 | UterineCorpusEndometrioidCarcinoma(TCGA,US) | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-3650 |
agtgACACACCcattgccc |
5 |
AGGUGUGU | m7b | Disrupted | -0.117 | no TS |
2.64 |
|
| hsa-miR-4455 |
agtgaCACACCCattgccc |
4 |
AGGGUGUG | m7b | Disrupted | -0.447 | -0.077 |
2.22 |
|
| hsa-miR-4506 |
agtgacacACCCATTgccc |
0 | AAAUGGGU | m7b | Disrupted | -0.062 | no TS |
2.62 |
|
| hsa-miR-4764-5p |
agtgaCACATCCAttgccc |
0 | UGGAUGUG | m8a | Created | no TS | -0.322 |
-7.93 |
|
| hsa-miR-609 |
agtgacACACCCattgccc |
4 |
AGGGUGUU | m6b | Disrupted | -0.234 | -0.076 |
2.61 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr20:g.44068890G>T | ICGC_1446314 | TCGA-BS-A0UV-01A-11D-A10B-09 | UterineCorpusEndometrioidCarcinoma(TCGA,US) | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-154-5p |
cagcccaaATAACCTgcag |
0 | UAGGUUAU | m7b | Created | no TS | -0.066 |
-7.1 |
|
| hsa-miR-5002-5p |
cagcCCAAATaacctgcag |
0 | AAUUUGGU | m6b | Created | no TS | 0.001 |
-5.33 |
|
| hsa-miR-9-5p |
cagcCCAAAGAacctgcag |
9 |
UCUUUGGU | m7a | Disrupted | -0.019 | no TS |
4 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr20:g.44068961G>A | COSN6687070 | CHC320T | [liver][NS][carcinoma][hepatocellular_carcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-143-5p |
tcgccCTGCACacggtacc |
0 | GGUGCAGU | m6b | Created | no TS | -0.057000 |
-0.070000 |
|
| hsa-miR-1973 |
tcgccctgcGCACGGTacc |
0 | ACCGUGCA | m7a | (m7a->m6b) | NA | NA |
2.070000 |
|
| hsa-miR-933 |
tcgcccTGCGCACggtacc |
0 | UGUGCGCA | m7b | Disrupted | -0.448000 | -0.263000 |
4.230000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr20:g.44069011G>C | COSN6687071 | CHC433T | [liver][NS][carcinoma][hepatocellular_carcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1224-3p |
cccagcccAGGTGGGccgc |
0 | CCCCACCU | m7b | Disrupted | -0.016000 | no TS |
-3.570000 |
|
| hsa-miR-378g |
cccAGCCCAGgtgggccgc |
0 | ACUGGGCU | m7b | (m7b->m6b) | -0.024000 | no TS |
3.090000 |
|
| hsa-miR-4417 |
cccAGCCCACgtgggccgc |
5 |
GGUGGGCU | m7b | (m6b->m7b) | -0.133000 | -0.236000 |
-2.830000 |
|
| hsa-miR-662 |
cccagcccACGTGGGccgc |
0 | UCCCACGU | m7b | Created | no TS | -0.084000 |
-5.520000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr20:g.44069027C>T | COSN7999755 | PCSI_0109_Pa_P | [pancreas][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-4258 |
cgccccTGGCGGGGtcgct |
2 |
CCCCGCCA | m8a | Disrupted | -0.141000 | no TS |
1.940000 |
|
| hsa-miR-4733-3p |
cgccCCTGGTGGggtcgct |
0 | CCACCAGG | m8a | Created | no TS | -0.030000 | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr20:g.44069298C>T | COSN1873262 | RK051_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-147b |
agggagacgCGCACAaaag |
0 | GUGUGCGG | m6b | Disrupted | -0.202000 | no TS |
0.050000 |
|
| hsa-miR-210 |
agggagacgCGCACAaaag |
0 | CUGUGCGU | m6b | Disrupted | -0.181000 | no TS |
-2.290000 |
|
| hsa-miR-933 |
agggagacGCGCACAaaag |
0 | UGUGCGCA | m7a | Disrupted | -0.448000 | -0.185000 | No effect | |
| hsa-miR-147b |
agggagacgCGCACAaaag |
0 | GUGUGCGG | m6b | Disrupted | -0.202 | no TS |
0.05 |
|
| hsa-miR-210 |
agggagacgCGCACAaaag |
0 | CUGUGCGU | m6b | Disrupted | -0.181 | no TS |
-2.29 |
|
| hsa-miR-933 |
agggagacGCGCACAaaag |
0 | UGUGCGCA | m7a | Disrupted | -0.448 | -0.185 | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr20:g.44069415G>A | COSN7093600 | 8031085 | [pancreas][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1181 |
taaattgccGGCGACGact |
1 |
CCGUCGCC | m7b | (m7b->m6c) | -0.665000 | -0.317000 |
5.280000 |
|
| hsa-miR-3128 |
taaaTTGCCAGcgacgact |
0 | UCUGGCAA | m7b | Created | no TS | -0.274000 |
-1.510000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr20:g.44069417C>T | COSN7093601 | 8015196 | [pancreas][NS][carcinoma][NS] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-miR-1181 |
aattgccGGCGACGacttt |
1 |
CCGUCGCC | m7b | Disrupted | -0.665000 | no TS |
3.290000 |
| Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
|---|---|---|---|---|---|---|---|---|---|
| 44068865 | rs189788213 | G | G |
hsa-miR-1587 hsa-miR-3620-5p hsa-miR-4417 hsa-miR-4492 hsa-miR-4498 hsa-miR-4656 hsa-miR-4675 hsa-miR-4741 hsa-miR-5001-5p hsa-miR-6829-5p hsa-miR-6882-3p hsa-miR-762 |
5 5 5 5 5 5 5 5 5 5 8 5 |
gaggCAGCCCAct gaggCAGCCCAct gaggcAGCCCACt gaggCAGCCCAct gaggCAGCCCAct gaggCAGCCCAct gaggCAGCCCAct gaggCAGCCCAct gaggCAGCCCAct gagGCAGCCCAct gAGGCAGCccact gaggCAGCCCAct |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N N N N N N |
-0.121 -0.121 -0.133 -0.112 -0.119 -0.135 -0.13 -0.13 -0.115 -0.372 -0.133 -0.105 |
| A |
hsa-miR-3152-5p hsa-miR-3940-5p hsa-miR-4423-5p hsa-miR-4507 hsa-miR-656-5p hsa-miR-6793-5p hsa-miR-6836-3p |
9 5 8 5 8 5 9 |
GAGGCAAcccact gaggCAACCCAct gAGGCAACccact gaggCAACCCAct gaGGCAACCcact gaggcAACCCACt GAGGCAAcccact |
Created Created Created Created Created Created Created |
N N N N N N N |
-0.114 -0.094 -0.104 -0.094 -0.219 -0.089 -0.093 |
|||
| 44069011 | rs6017258 | C | G |
hsa-miR-1224-3p hsa-miR-378g hsa-miR-6765-3p hsa-miR-7851-3p hsa-miR-939-3p |
0 |
agcccAGGTGGGc AGCCCAGgtgggc agcCCAGGTGggc agCCCAGGTgggc aGCCCAGGtgggc |
Created Created Created Created Created |
N N N N N |
-0.016 -0.024 -0.016 -0.05 -0.126 |
| C |
hsa-miR-4417 hsa-miR-662 |
0 |
AGCCCACgtgggc agcccACGTGGGc |
Disrupted Disrupted |
N N |
-0.103 -0.084 |