SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001098796
Gene Symbol:	TOX2
Description:	Homo sapiens TOX high mobility group box family member 2 (TOX2), transcript variant 4, mRNA.
Gene Location:	chr20(+):42544781-42698254
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr20:g.44068717T>G			ICGC_1446312		TCGA-BS-A0UV-01A-11D-A10B-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1471	gaggctCGCGGGaaggcac	0	GCCCGCGU	m6b	Created	no TS	-0.303	-2.63
hsa-miR-4738-5p	gaggctCGCTGGaaggcac	5	ACCAGCGC	m6b	Disrupted	-0.226	no TS	9.76

Mutation			Mutation ID		Sample Name		Cancer Type
chr20:g.44068808C>T			ICGC_1446313		TCGA-BS-A0UV-01A-11D-A10B-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3650	agtgACACACCcattgccc	5	AGGUGUGU	m7b	Disrupted	-0.117	no TS	2.64
hsa-miR-4455	agtgaCACACCCattgccc	4	AGGGUGUG	m7b	Disrupted	-0.447	-0.077	2.22
hsa-miR-4506	agtgacacACCCATTgccc	0	AAAUGGGU	m7b	Disrupted	-0.062	no TS	2.62
hsa-miR-4764-5p	agtgaCACATCCAttgccc	0	UGGAUGUG	m8a	Created	no TS	-0.322	-7.93
hsa-miR-609	agtgacACACCCattgccc	4	AGGGUGUU	m6b	Disrupted	-0.234	-0.076	2.61

Mutation			Mutation ID		Sample Name		Cancer Type
chr20:g.44068890G>T			ICGC_1446314		TCGA-BS-A0UV-01A-11D-A10B-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-154-5p	cagcccaaATAACCTgcag	0	UAGGUUAU	m7b	Created	no TS	-0.066	-7.1
hsa-miR-5002-5p	cagcCCAAATaacctgcag	0	AAUUUGGU	m6b	Created	no TS	0.001	-5.33
hsa-miR-9-5p	cagcCCAAAGAacctgcag	9	UCUUUGGU	m7a	Disrupted	-0.019	no TS	4

Mutation			Mutation ID		Sample Name		Cancer Type
chr20:g.44068961G>A			COSN6687070		CHC320T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-143-5p	tcgccCTGCACacggtacc	0	GGUGCAGU	m6b	Created	no TS	-0.057000	-0.070000
hsa-miR-1973	tcgccctgcGCACGGTacc	0	ACCGUGCA	m7a	(m7a->m6b)	NA	NA	2.070000
hsa-miR-933	tcgcccTGCGCACggtacc	0	UGUGCGCA	m7b	Disrupted	-0.448000	-0.263000	4.230000

Mutation			Mutation ID		Sample Name		Cancer Type
chr20:g.44069011G>C			COSN6687071		CHC433T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1224-3p	cccagcccAGGTGGGccgc	0	CCCCACCU	m7b	Disrupted	-0.016000	no TS	-3.570000
hsa-miR-378g	cccAGCCCAGgtgggccgc	0	ACUGGGCU	m7b	(m7b->m6b)	-0.024000	no TS	3.090000
hsa-miR-4417	cccAGCCCACgtgggccgc	5	GGUGGGCU	m7b	(m6b->m7b)	-0.133000	-0.236000	-2.830000
hsa-miR-662	cccagcccACGTGGGccgc	0	UCCCACGU	m7b	Created	no TS	-0.084000	-5.520000

Mutation			Mutation ID		Sample Name		Cancer Type
chr20:g.44069027C>T			COSN7999755		PCSI_0109_Pa_P		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4258	cgccccTGGCGGGGtcgct	2	CCCCGCCA	m8a	Disrupted	-0.141000	no TS	1.940000
hsa-miR-4733-3p	cgccCCTGGTGGggtcgct	0	CCACCAGG	m8a	Created	no TS	-0.030000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr20:g.44069298C>T			COSN1873262		RK051_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-147b	agggagacgCGCACAaaag	0	GUGUGCGG	m6b	Disrupted	-0.202000	no TS	0.050000
hsa-miR-210	agggagacgCGCACAaaag	0	CUGUGCGU	m6b	Disrupted	-0.181000	no TS	-2.290000
hsa-miR-933	agggagacGCGCACAaaag	0	UGUGCGCA	m7a	Disrupted	-0.448000	-0.185000	No effect
hsa-miR-147b	agggagacgCGCACAaaag	0	GUGUGCGG	m6b	Disrupted	-0.202	no TS	0.05
hsa-miR-210	agggagacgCGCACAaaag	0	CUGUGCGU	m6b	Disrupted	-0.181	no TS	-2.29
hsa-miR-933	agggagacGCGCACAaaag	0	UGUGCGCA	m7a	Disrupted	-0.448	-0.185	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr20:g.44069415G>A			COSN7093600		8031085		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1181	taaattgccGGCGACGact	1	CCGUCGCC	m7b	(m7b->m6c)	-0.665000	-0.317000	5.280000
hsa-miR-3128	taaaTTGCCAGcgacgact	0	UCUGGCAA	m7b	Created	no TS	-0.274000	-1.510000

Mutation			Mutation ID		Sample Name		Cancer Type
chr20:g.44069417C>T			COSN7093601		8015196		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1181	aattgccGGCGACGacttt	1	CCGUCGCC	m7b	Disrupted	-0.665000	no TS	3.290000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

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