SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_000113
Gene Symbol: TOR1A
Description: Homo sapiens torsin family 1, member A (torsin A) (TOR1A), mRNA.
Gene Location: chr9(-):132575220-132586441

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr9:g.129813653A>C COSN6380819 RK163_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-324-5p ggaaGGATGCataagtttt
0 CGCAUCCC m6b Created no TS -0.190000 -0.300000
hsa-miR-491-3p ggaaggaTGCATAAGtttt
0 CUUAUGCA m8a Created no TS -0.185000 -0.510000
hsa-miR-5196-3p ggaAGGATGAataagtttt
4
UCAUCCUC m7a (m7a->m6b) -0.303000 -0.183000 0.120000
hsa-miR-586 ggaaggATGCATAagtttt
0 UAUGCAUU m7a Created no TS -0.071000 -0.180000
hsa-miR-664-3p ggaaggATGAATAagtttt
3
UAUUCAUU m7a Disrupted -0.011000 no TS 1.300000

Mutation Mutation ID Sample Name Cancer Type
chr9:g.129813761G>A COSN8316098 TCGA-AN-A046-01 [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-30b-3p aagCCTCCCAaacacgcac
0 CUGGGAGG m7b (m6c->m7b) no TS -0.303000 -0.020000
hsa-miR-30c-1-3p aagcCTCCCAaacacgcac
0 CUGGGAGA m6b Created no TS -0.095000 No effect
hsa-miR-30c-2-3p aagcCTCCCAaacacgcac
0 CUGGGAGA m6b Created no TS -0.095000 -0.030000
hsa-miR-3122 aagccTCCCAAacacgcac
0 GUUGGGAC m6b Created no TS -0.057000 -0.240000
hsa-miR-3676-3p aagcctcccAAACACGcac
0 CCGUGUUU m7b (m6b->m7b) no TS -0.093000 -0.190000
hsa-miR-3689a-3p aagCCTCCCAaacacgcac
0 CUGGGAGG m7b (m6c->m7b) no TS -0.293000 -0.570000
hsa-miR-3689b-3p aagCCTCCCAaacacgcac
0 CUGGGAGG m7b (m6c->m7b) no TS -0.272000 -0.140000
hsa-miR-3689c aagCCTCCCAaacacgcac
0 CUGGGAGG m7b (m6c->m7b) no TS -0.272000 -0.140000
hsa-miR-425-3p aagccTCCCGAacacgcac
0 AUCGGGAA m6b Disrupted -0.190000 no TS 9.450000
hsa-miR-4728-5p aagCCTCCCAaacacgcac
0 UGGGAGGG m7a (m6b->m7a) no TS -0.121000 -0.470000

Mutation Mutation ID Sample Name Cancer Type
chr9:g.129813784C>T COSN7557592 8016470 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4641 cagggacCATGGGCgagga
0 UGCCCAUG m7b Created no TS -0.130000 No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
129813011 rs79201718 T T hsa-miR-4310
hsa-miR-5196-3p
hsa-miR-7157-5p
4
3
4
tgaggATGCTGAg
tGAGGATGctgag
tgaggATGCTGAg
Disrupted
Disrupted
Disrupted
N
N
N
-0.092
-0.183
-0.098
A hsa-miR-516a-3p
hsa-miR-516b-3p
hsa-miR-670-3p
hsa-miR-6787-3p
hsa-miR-7162-5p
6
6
2
5
6
tgAGGAAGCtgag
tgAGGAAGCtgag
TGAGGAAgctgag
tgaggaAGCTGAG
tgAGGAAGCtgag
Created
Created
Created
Created
Created
N
N
N
N
N
-0.194
-0.194
-0.084
-0.226
-0.185

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