SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_003276
Gene Symbol:	TMPO
Description:	Homo sapiens thymopoietin (TMPO), transcript variant 2, mRNA.
Gene Location:	chr12(+):98909350-98929412
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.98534353G>C			COSN8407356		B77-Tumor		[urinary_tract][bladder][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-2113	aaaattaaGCACAAAaaga	0	AUUUGUGC	m7b	Created	no TS	0.000000	No effect
hsa-miR-218-5p	aaaattAAGCACAAaaaga	0	UUGUGCUU	m8a	Created	no TS	0.000000	No effect
hsa-miR-2355-3p	aaaattaAGGACAAaaaga	0	AUUGUCCU	m7b	Disrupted	0.000000	no TS	No effect
hsa-miR-4646-3p	aaaattaaGGACAAaaaga	0	AUUGUCCC	m6b	Disrupted	0.000000	no TS	-0.480000
hsa-miR-5010-3p	aaaattaagCACAAAAaga	0	UUUUGUGU	m7a	(m6b->m7a)	no TS	0.000000	No effect
hsa-miR-636	aaaattAAGCACAaaaaga	0	UGUGCUUG	m7a	Created	no TS	0.000000	No effect
hsa-miR-676-3p	aaaattaAGGACAaaaaga	0	CUGUCCUA	m6b	Disrupted	-0.318000	-0.159000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.98534863A>G			COSN8770873		AOCS-135-8-X		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3136-5p	gcaacaTCAGTCAtagtag	0	CUGACUGA	m7b	Created	no TS	-0.177000	-0.070000
hsa-miR-4439	gcaacaTCAGTCAtagtag	0	GUGACUGA	m7b	Created	no TS	-0.196000	-0.700000
hsa-miR-4513	gcaacaTCAGTCatagtag	0	AGACUGAC	m6b	Created	no TS	-0.108000	-9.530000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.98534895C>T			COSN5872599		RK216_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3907	aactcaaAGCACCagtcta	1	AGGUGCUC	m6b	Disrupted	-0.137000	no TS	8.410000
hsa-miR-548q	aactcaaaGCACCAGtcta	1	GCUGGUGC	m7b	Disrupted	-0.245000	no TS	1.940000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.98535417A>G			COSN5332457		RK131_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4633-5p	gtagccttAGGCATAataa	0	AUAUGCCU	m7b	Created	no TS	-0.430000	-5.890000
hsa-miR-4720-3p	gtagcCTTAAGCAtaataa	2	UGCUUAAG	m8a	Disrupted	-0.282000	no TS	0.990000
hsa-miR-532-5p	gtagccttAGGCATaataa	0	CAUGCCUU	m6b	Created	no TS	-0.153000	-4.450000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
98534712	rs17028453	A	A	hsa-miR-4743-3p hsa-miR-4778-5p hsa-miR-5571-3p hsa-miR-676-3p hsa-miR-6888-3p	2 2 3 2 2	cctagGACAGAAt cctaggACAGAAT CCTAGGAcagaat ccTAGGACAgaat cctagGACAGAAt	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.14 -0.089 -0.232 -0.159 -0.126
			T	hsa-miR-192-5p hsa-miR-215-5p hsa-miR-4256 hsa-miR-4750-3p	2 2 2 2	ccTAGGTCAgaat ccTAGGTCAgaat cctaGGTCAGAAt cctaGGTCAGAat	Created Created Created Created	HT HT N N	-0.173 -0.173 -0.442 -0.166

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