SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_138554
Gene Symbol: TLR4
Description: Homo sapiens toll-like receptor 4 (TLR4), transcript variant 1, mRNA.
Gene Location: chr9(+):120466459-120479766
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr9:g.117714775C>G COSN6377805 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-130a-3p catggTGCACTagatatgc
 1
 CAGUGCAA m6b Disrupted -0.125000 no TS 0.100000
hsa-miR-130b-3p catggTGCACTagatatgc
 1
 CAGUGCAA m6b Disrupted -0.132000 no TS 1.100000
hsa-miR-301a-3p catggTGCACTagatatgc
 1
 CAGUGCAA m6b Disrupted -0.132000 no TS No effect
hsa-miR-301b catggTGCACTagatatgc
 1
 CAGUGCAA m6b Disrupted -0.132000 no TS 0.290000
hsa-miR-3130-3p catGGTGCAGtagatatgc
 7
 GCUGCACC m7b (m6b->m7b) -0.122000 -0.403000 -1.210000
hsa-miR-3666 catggTGCACTagatatgc
 1
 CAGUGCAA m6b Disrupted -0.125000 no TS 0.010000
hsa-miR-4295 catggTGCACTagatatgc
 1
 CAGUGCAA m6b Disrupted -0.122000 no TS No effect
hsa-miR-4418 catggTGCAGTagatatgc
 1
 CACUGCAG m6b Created -0.144000 -0.245000 -0.500000
hsa-miR-4473 catggtGCACTAGatatgc
 0 CUAGUGCU m7a Disrupted NA NA No effect
hsa-miR-4671-3p catggTGCACTAgatatgc
 1
 UUAGUGCA m7b Disrupted -0.164000 no TS 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr9:g.117715294C>T COSN8294334 PCSI_0083_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3646 tccagttTTCATTTTttta
 1
 AAAAUGAA m8a Disrupted 0.064000 0.085000 No effect
hsa-miR-3662 tccagtttTCATTTTttta
 3
 GAAAAUGA m7b Disrupted 0.089000 0.101000 1.040000
hsa-miR-548ac tccaGTTTTTattttttta
 0 CAAAAACC m6b Created no TS 0.060000 -1.770000
hsa-miR-548ae tccAGTTTTTattttttta
 0 CAAAAACU m7b (m6b->m7b) no TS 0.023000 -0.280000
hsa-miR-548ah-3p tccAGTTTTTattttttta
 0 CAAAAACU m7b (m6b->m7b) no TS 0.023000 -0.280000
hsa-miR-548aj-3p tccAGTTTTTAttttttta
 0 UAAAAACU m8a Created no TS 0.023000 -0.250000
hsa-miR-548am-3p tccAGTTTTTattttttta
 0 CAAAAACU m7b (m6b->m7b) no TS 0.023000 -0.240000
hsa-miR-548aq-3p tccAGTTTTTattttttta
 0 CAAAAACU m7b (m6b->m7b) no TS 0.023000 -0.280000
hsa-miR-548d-3p tccaGTTTTTattttttta
 0 CAAAAACC m6b Created no TS 0.074000 0.620000
hsa-miR-548e tcCAGTTTTTattttttta
 2
 AAAAACUG m8a (m7a->m8a) -0.129000 -0.156000 0.100000
hsa-miR-548f tcCAGTTTTTattttttta
 2
 AAAAACUG m8a (m7a->m8a) -0.129000 -0.156000 0.160000
hsa-miR-548h-3p tccaGTTTTTattttttta
 0 CAAAAACC m6b Created no TS 0.060000 0.620000
hsa-miR-548x-3p tccAGTTTTTAttttttta
 0 UAAAAACU m8a Created no TS 0.023000 -0.250000
hsa-miR-548z tccaGTTTTTattttttta
 0 CAAAAACC m6b Created no TS 0.060000 0.620000
hsa-miR-570-3p tccaGTTTTCattttttta
 3
 CGAAAACA m6b Disrupted 0.011000 no TS 0.390000

Mutation Mutation ID Sample Name Cancer Type
chr9:g.117715798G>T COSN6377806 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1304-3p tcaaggCAGTGAGtataca
 0 UCUCACUG m7b Created no TS -0.016000 No effect
hsa-miR-3680-5p tcaaggcAGTGAGTataca
 1
 GACUCACU m7b Created -0.140000 -0.198000 0.370000
hsa-miR-4798-3p tcaaggcaGTGAGTataca
 1
 AACUCACG m6b Created -0.180000 -0.246000 -0.080000

Mutation Mutation ID Sample Name Cancer Type
chr9:g.117715997A>C ICGC_A64AC6D0-2A78-11E2-8335-12FD496BB9B8 CPCG_0102_Pr_P_P2 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-335-3p agggaaATGAAAAtaaaaa
 2
 UUUUUCAU m7b Disrupted 0.419 0.324 -1.05
hsa-miR-33a-5p agggaAATGCAaataaaaa
 0 GUGCAUUG m6b Created no TS 0.047 -0.56
hsa-miR-33b-5p agggaAATGCAaataaaaa
 0 GUGCAUUG m6b Created no TS 0.047 -0.03
hsa-miR-3680-3p agggaaATGCAAAtaaaaa
 0 UUUUGCAU m7b Created no TS -0.02 -3.56
hsa-miR-5696 agggAAATGAaaataaaaa
 2
 CUCAUUUA m6b Disrupted 0.26 0.13 0.01
hsa-miR-579 agggAAATGAAaataaaaa
 2
 UUCAUUUG m7a Disrupted 0.261 0.131 No effect
hsa-miR-644b-3p agggAAATGAAaataaaaa
 2
 UUCAUUUG m7a Disrupted 0.26 0.127 No effect


Mutation Mutation ID Sample Name Cancer Type
chr9:g.117716245A>C COSN15189125 SM-4AX86 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr9:g.117716353A>T COSN8120405 8066491 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-501-3p aaaatGTGCATatacgtac
 2
 AAUGCACC m6b Disrupted -0.060000 no TS 0.030000
hsa-miR-502-3p aaaatGTGCATatacgtac
 2
 AAUGCACC m6b Disrupted -0.060000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr9:g.117716359G>A COSN9697627 AOCS-105-1-9 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-297 tgcatatACATACAatggg
 0 AUGUAUGU m7b Created no TS -0.092000 -2.490000
hsa-miR-3149 tgcatataCATACAAtggg
 0 UUUGUAUG m7b Created no TS -0.036000 -0.930000
hsa-miR-3924 tgcatATACATAcaatggg
 1
 AUAUGUAU m7b Created -0.249000 -0.229000 -0.120000
hsa-miR-567 tgcatatACATACaatggg
 0 AGUAUGUU m6b Created no TS -0.003000 -1.390000
hsa-miR-568 tgcaTATACATacaatggg
 0 AUGUAUAA m7a Created NA NA -0.040000
hsa-miR-675-3p tgcatataCATACAatggg
 0 CUGUAUGC m6b Created no TS -0.017000 -0.030000

Mutation Mutation ID Sample Name Cancer Type
chr9:g.117716616C>T ICGC_8171647C-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-200a-5p tatagtatGTAAGATGaat
 0 CAUCUUAC m8a Created -0.079 -0.17 -1.01
hsa-miR-200b-5p tatagtatGTAAGATGaat
 0 CAUCUUAC m8a Created -0.072 -0.163 -0.8
hsa-miR-5689 tataGTATGCaagatgaat
 2
 AGCAUACA m6b Disrupted -0.095 no TS 2.01
hsa-miR-600 tatagtaTGTAAGatgaat
 0 ACUUACAG m6b Created no TS -0.015 -2.48

Mutation Mutation ID Sample Name Cancer Type
chr9:g.117716691A>G COSN6377807 RK219_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-424-3p gcacttaACGTTTTGttaa
 0 CAAAACGU m8a Created no TS -0.097000 -1.340000
hsa-miR-4698 gcacttaaCATTTTGttaa
 0 UCAAAAUG m7b Disrupted 0.082000 0.097000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr9:g.117717019G>A COSN14906473 LP6005409-DNA_F02 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1915-3p catCCCTGGGtgtgtttcc
 2
 CCCCAGGG m7b (m7b->m6b) -0.192000 no TS 3.620000
hsa-miR-329 catccctgGGTGTGTTtcc
 0 AACACACC m8a Disrupted -0.169000 -0.068000 0.920000
hsa-miR-362-3p catccctgGGTGTGTTtcc
 0 AACACACC m8a Disrupted -0.193000 -0.074000 2.330000

Mutation Mutation ID Sample Name Cancer Type
chr9:g.117717103G>A COSN8120406 8030032 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-329 gggctGTGTGTatttgaaa
 0 AACACACC m6b Disrupted -0.169000 -0.101000 No effect
hsa-miR-362-3p gggctGTGTGTatttgaaa
 0 AACACACC m6b Disrupted -0.193000 -0.119000 -0.100000
hsa-miR-3941 gggctGTGTGTAtttgaaa
 0 UUACACAC m7b Disrupted -0.141000 no TS 0.920000
hsa-miR-4672 gggCTGTGTAtatttgaaa
 0 UUACACAG m7b (m6b->m7b) no TS -0.090000 -1.100000
hsa-miR-4789-5p gggctGTGTATAtttgaaa
 0 GUAUACAC m7b Created no TS -0.101000 -1.300000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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