| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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| RefSeq ID: | NM_003253 |
|---|---|
| Gene Symbol: | TIAM1 |
| Description: | Homo sapiens T-cell lymphoma invasion and metastasis 1 (TIAM1), mRNA. |
| Gene Location: | chr21(-):32490735-32931290 |
| Browse Associations | |
| Browse Pathways | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr21:g.31118691C>T | COSN9156550 | AOCS-160-1-6 | [ovary][NS][other][neoplasm] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-143-3p |
ccataTCATCTCcggttcg |
9 |
UGAGAUGA | m7b | Disrupted | -0.120000 | no TS |
0.010000 |
|
| hsa-miR-3682-3p |
ccaTATCATCtccggttcg |
9 |
UGAUGAUA | m7b | (m7b->m6c) | -0.118000 | no TS | No effect | |
| hsa-miR-4770 |
ccataTCATCTCcggttcg |
9 |
UGAGAUGA | m7b | Disrupted | -0.120000 | no TS |
2.230000 |
|
| hsa-miR-5093 |
ccatatCATTTCCggttcg |
15 |
AGGAAAUG | m7b | Created | -0.024000 | -0.151000 | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr21:g.31118692T>A | COSN9156551 | AOCS-160-1-6 | [ovary][NS][other][neoplasm] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-143-3p |
tccataTCATCTCcggttc |
9 |
UGAGAUGA | m7b | Disrupted | -0.120000 | no TS |
0.010000 |
|
| hsa-miR-219-1-3p |
tccataTCAACTCcggttc |
0 | AGAGUUGA | m7b | Created | no TS | -0.180000 |
-6.650000 |
|
| hsa-miR-3682-3p |
tccaTATCATCtccggttc |
9 |
UGAUGAUA | m7b | Disrupted | -0.118000 | no TS | No effect | |
| hsa-miR-4770 |
tccataTCATCTCcggttc |
9 |
UGAGAUGA | m7b | Disrupted | -0.120000 | no TS |
5.210000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr21:g.31118693A>G | COSN8611654 | 3608_T | [lung][NS][carcinoma][squamous_cell_carcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-143-3p |
ttccataTCATCTCcggtt |
9 |
UGAGAUGA | m7b | Disrupted | -0.120000 | no TS |
0.010000 |
|
| hsa-miR-3682-3p |
ttccaTATCATCtccggtt |
9 |
UGAUGAUA | m7b | Disrupted | -0.118000 | no TS | No effect | |
| hsa-miR-4770 |
ttccataTCATCTCcggtt |
9 |
UGAGAUGA | m7b | Disrupted | -0.120000 | no TS |
0.720000 |
|
| hsa-miR-5091 |
ttccatatcGTCTCCGgtt |
0 | ACGGAGAC | m7b | (m6b->m7b) | no TS | -0.268000 |
-5.200000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr21:g.31118765A>C | COSN6561971 | ICGC_MB121 | [central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-2278 |
attttTGCTCTatcttctg |
0 | GAGAGCAG | m6b | Created | no TS | -0.147000 |
0.030000 |
|
| hsa-miR-4662a-3p |
atttttgctCTATCTTctg |
4 |
AAAGAUAG | m7b | (m6b->m7b) | -0.099000 | -0.223000 |
-0.470000 |
|
| hsa-miR-4766-3p |
atttTTGCTATatcttctg |
0 | AUAGCAAU | m7a | Disrupted | NA | NA |
5.730000 |
|
| hsa-miR-548p |
atTTTTGCTAtatcttctg |
19 |
UAGCAAAA | m8a | (m8a->m7b) | -0.236000 | -0.141000 |
1.300000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr21:g.31119209C>T | COSN8611655 | J10_T | [lung][NS][carcinoma][squamous_cell_carcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1306-3p |
tcatGCCAACGaaacaggg |
3 |
ACGUUGGC | m7b | Disrupted | -0.450000 | no TS |
3.850000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr21:g.31119412G>T | COSN5985186 | RK175_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1280 |
cacccCGGTGGGcggtgtg |
0 | UCCCACCG | m7b | Disrupted | -0.046000 | no TS | No effect | |
| hsa-miR-4655-5p |
caCCCCGGTGggcggtgtg |
0 | CACCGGGG | m8a | (m8a->m7b) | -0.205000 | -0.232000 | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr21:g.31120143T>C | COSN8006926 | ASHPC_0011_Pa_P | [pancreas][NS][carcinoma][NS] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-let-7f-2-3p |
tatcttCTGTATAttacta |
0 | CUAUACAG | m7b | Disrupted | -0.144000 | no TS |
0.820000 |
| hsa-miR-1185-1-3p |
tatcttCTGTATATtacta |
0 | AUAUACAG | m8a | Disrupted | -0.200000 | no TS |
0.320000 |
| hsa-miR-1185-2-3p |
tatcttCTGTATATtacta |
0 | AUAUACAG | m8a | Disrupted | -0.200000 | no TS |
0.320000 |
| hsa-miR-1277-5p |
tatcttctgTATATTacta |
3 |
AAAUAUAU | m6b | Disrupted | -0.018000 | -0.057000 |
0.010000 |
| hsa-miR-298 |
tatCTTCTGCatattacta |
0 | AGCAGAAG | m7b | (m6c->m7b) | no TS | -0.386000 |
-0.040000 |
| hsa-miR-4517 |
tatcttctgCATATTacta |
0 | AAAUAUGA | m6b | Created | no TS | -0.011000 |
-0.190000 |
| hsa-miR-5583-3p |
tatcttctgCATATTacta |
0 | GAAUAUGG | m6b | Created | no TS | -0.023000 |
0.040000 |
| Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
|---|---|---|---|---|---|---|---|---|---|
| 31118765 | rs73191626 | A | A |
hsa-miR-548p |
19 |
TTTGCTAtatctt |
Disrupted |
N |
-0.095 |
| G |
hsa-miR-3120-3p hsa-miR-545-3p |
14 19 |
tTTGCTGTAtctt TTTGCTGtatctt |
Created Created |
N N |
-0.333 -0.236 |