SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001080427
Gene Symbol:	THSD7B
Description:	Homo sapiens thrombospondin, type I, domain containing 7B (THSD7B), mRNA.
Gene Location:	chr2(+):137748461-138435287
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.137676695C>A			COSN6191591		RK308_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-376a-5p	gagGAATCTAaagatgtga	0	GUAGAUUC	m7b	(m6b->m7b)	no TS	-0.268000	-0.310000
hsa-miR-4760-5p	gaggAATCTAAAgatgtga	10	UUUAGAUU	m8a	Created	-0.088000	-0.226000	-0.020000
hsa-miR-5186	gaggAATCTCaagatgtga	15	AGAGAUUG	m6b	Disrupted	-0.100000	no TS	-0.760000
hsa-miR-526b-5p	gaggaatCTCAAGAtgtga	14	CUCUUGAG	m7b	Disrupted	-0.356000	-0.145000	0.070000

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.137676722A>T			COSN8607544		3765_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-630	gcAGAATACTaatattgca	12	AGUAUUCU	m8a	(m7a->m8a)	-0.263000	-0.149000	1.160000

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.137676795T>C			COSN5781967		HCC93		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-548p	gccaTTTTGCTttcaagtt	0	UAGCAAAA	m7b	Created	no TS	-0.125000	-0.050000
hsa-miR-570-3p	gccatttTGTTTTCaagtt	8	CGAAAACA	m7b	Disrupted	-0.196000	no TS	0.910000
hsa-miR-548p	gccaTTTTGCTttcaagtt	0	UAGCAAAA	m7b	Created	no TS	-0.125000	-0.050000
hsa-miR-570-3p	gccatttTGTTTTCaagtt	8	CGAAAACA	m7b	Disrupted	-0.196000	no TS	0.910000

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.137676993C>T			COSN6191592		RK144_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-2115-3p	cgagTCTGATactgcattg	0	CAUCAGAA	m6b	Created	no TS	-0.051000	-0.820000
hsa-miR-361-5p	cgagTCTGATActgcattg	0	UUAUCAGA	m7b	Created	no TS	-0.071000	-5.170000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
137676718	rs188725373	A	A	hsa-miR-3149 hsa-miR-4727-5p hsa-miR-4778-5p hsa-miR-5001-3p hsa-miR-630 hsa-miR-6738-3p	10 17 14 17 12 17	ggcagaATACAAA GGCAGAAtacaaa ggCAGAATAcaaa GGCAGAAtacaaa ggcAGAATACAaa GGCAGAAtacaaa	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N	-0.031 -0.224 -0.063 -0.207 -0.263 -0.246
			G	hsa-miR-3664-5p hsa-miR-4714-5p hsa-miR-514a-5p	14 14 14	ggCAGAGTAcaaa ggCAGAGTAcaaa ggCAGAGTAcaaa	Created Created Created	N N N	-0.132 -0.137 -0.133
137677584	rs147909697	C	C	hsa-miR-4760-5p hsa-miR-8061	10 10	taatATCTAAAac taatATCTAAAac	Disrupted Disrupted	N N	-0.088 -0.078

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