SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_003242
Gene Symbol:	TGFBR2
Description:	Homo sapiens transforming growth factor, beta receptor II (70/80kDa) (TGFBR2), transcript variant 1, mRNA.
Gene Location:	chr3(+):30647993-30735633
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Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.30691800A>G			COSN1945906		RK177_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-202-5p	gacattgtCATAGGAtaag	14	UUCCUAUG	m7b	Disrupted	-0.565000	-0.372000	-0.020000
hsa-miR-425-5p	gacatTGTCATaggataag	12	AAUGACAC	m6b	Disrupted	-0.076000	no TS	13.430000

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.30692281A>T			COSN6426623		HX34T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-539-5p	tgtgcccttATTTCTCCtg	1	GGAGAAAU	m8a	(m8a->m7b)	0.050000	no TS	0.060000

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.30693226C>T			COSN8489100		J57_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3915	agctTTCCTCAtggttacc	15	UUGAGGAA	m7b	Disrupted	-0.151000	-0.109000	0.080000
hsa-miR-3928	agctTTCCTCatggttacc	15	GGAGGAAC	m6b	Disrupted	-0.122000	-0.107000	No effect
hsa-miR-4496	agcTTTCCTCatggttacc	0	GAGGAAAC	m7a	(m7a->m6a)	NA	NA	-0.040000

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.30693399G>C			COSN9547763		AOCS-055-1-7		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.30693615G>C			COSN7605636		8031121		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-302b-5p	agaGTTAAAGacagtgtgg	0	ACUUUAAC	m7b	(m7b->m6b)	0.003000	no TS	0.060000
hsa-miR-302d-5p	agaGTTAAAGacagtgtgg	0	ACUUUAAC	m7b	(m7b->m6b)	0.003000	no TS	0.070000
hsa-miR-511	agagttAAAGACAgtgtgg	1	GUGUCUUU	m7b	Disrupted	-0.035000	no TS	6.170000
hsa-miR-892a	agagttaaACACAGTGtgg	0	CACUGUGU	m8a	Created	no TS	-0.121000	-0.210000

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.30693871G>T			COSN14847545		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-212-5p	aagaCCAAGGaataacatt	16	ACCUUGGC	m6b	Disrupted	-0.162000	no TS	No effect
hsa-miR-3189-3p	aagaCCAAGGaataacatt	16	CCCUUGGG	m6b	Disrupted	-0.161000	no TS	No effect
hsa-miR-502-5p	aagacCAAGGAataacatt	0	AUCCUUGC	m6b	Disrupted	-0.249000	-0.108000	No effect
hsa-miR-556-3p	aagaccaaGTAATAacatt	0	AUAUUACC	m6b	Created	no TS	-0.034000	No effect
hsa-miR-890	aagaCCAAGTAataacatt	0	UACUUGGA	m7a	Created	no TS	-0.141000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.30693899C>T			COSN14461379		8068554		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-16-1-3p	ctaaaAATACTGacttttt	11	CCAGUAUU	m7b	Disrupted	-0.284000	-0.036000	0.060000
hsa-miR-16-2-3p	ctaaaAATATTGacttttt	0	CCAAUAUU	m7b	Created	no TS	-0.157000	-0.110000
hsa-miR-195-3p	ctaaaAATATTGacttttt	0	CCAAUAUU	m7b	Created	no TS	-0.147000	-3.080000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

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