SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_017628
Gene Symbol: TET2
Description: Homo sapiens tet methylcytosine dioxygenase 2 (TET2), transcript variant 1, mRNA.
Gene Location: chr4(+):106067031-106163928
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr4:g.105237679C>T COSN9898125 C0032T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3675-3p ctggAGAGATagctaggca
 2
 CAUCUCUA m6b Created -0.006000 -0.067000 -0.230000
hsa-miR-626 ctggagAGACAGCTaggca
 4
 AGCUGUCU m8a Disrupted -0.171000 -0.012000 2.860000

Mutation Mutation ID Sample Name Cancer Type
chr4:g.105237994A>G COSN1284698 HX17T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-338-5p acctcagagATATTGTggg
 2
 AACAAUAU m7b (m7b->m6c) 0.169000 0.110000 No effect
hsa-miR-3675-3p acctcAGAGATattgtggg
 2
 CAUCUCUA m6b Disrupted -0.006000 0.041000 No effect
hsa-miR-3921 acCTCAGAGAtattgtggg
 3
 UCUCUGAG m8a (m8a->m7a) -0.280000 -0.152000 -0.720000
hsa-miR-4653-5p acCTCAGAGAtattgtggg
 3
 UCUCUGAG m8a (m8a->m7a) -0.238000 -0.114000 -0.370000
hsa-miR-875-5p acctcaGAGGTATtgtggg
 2
 UAUACCUC m7b Created -0.120000 -0.279000 No effect
hsa-miR-338-5p acctcagagATATTGTggg
 0 AACAAUAU m7b (m7b->m6c) 0.169 0.11 No effect
hsa-miR-3675-3p acctcAGAGATattgtggg
 2
 CAUCUCUA m6b Disrupted -0.006 0.041 No effect
hsa-miR-3921 acCTCAGAGAtattgtggg
 3
 UCUCUGAG m8a (m8a->m7a) -0.28 -0.152 -0.72
hsa-miR-4653-5p acCTCAGAGAtattgtggg
 3
 UCUCUGAG m8a (m8a->m7a) -0.238 -0.114 -0.37
hsa-miR-875-5p acctcaGAGGTATtgtggg
 0 UAUACCUC m7b Created -0.12 -0.279 No effect

Mutation Mutation ID Sample Name Cancer Type
chr4:g.105238093A>G COSN5548044 RK088_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-410 gttatTTATATactatact
 2
 AAUAUAAC m6b Disrupted 0.064000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr4:g.105238241T>C COSN8489861 J63_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-200b-3p gtgcttCAGTATTgatcgc
 3
 UAAUACUG m7b Disrupted -0.061000 -0.101000 0.010000
hsa-miR-200c-3p gtgcttCAGTATTgatcgc
 3
 UAAUACUG m7b Disrupted -0.061000 -0.101000 No effect
hsa-miR-429 gtgcttCAGTATTgatcgc
 3
 UAAUACUG m7b Disrupted -0.047000 -0.069000 1.100000
hsa-miR-4724-5p gtgcTTCAGTattgatcgc
 4
 AACUGAAC m6b Disrupted 0.026000 0.004000 0.010000
hsa-miR-4728-3p gtgctTCAGCATtgatcgc
 0 CAUGCUGA m7b Created -0.003000 -0.095000 -0.030000

Mutation Mutation ID Sample Name Cancer Type
chr4:g.105238595T>G COSN5050307 HX19T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-548ae ttatcaAGTTTTTtcatga
 0 CAAAAACU m7b Disrupted 0.165000 0.066000 No effect
hsa-miR-548ah-3p ttatcaAGTTTTTtcatga
 0 CAAAAACU m7b Disrupted 0.146000 0.047000 0.010000
hsa-miR-548aj-3p ttatcaAGTTTTTtcatga
 0 UAAAAACU m7b Disrupted 0.165000 0.066000 No effect
hsa-miR-548am-3p ttatcaAGTTTTTtcatga
 0 CAAAAACU m7b Disrupted 0.146000 0.047000 0.010000
hsa-miR-548aq-3p ttatcaAGTTTTTtcatga
 0 CAAAAACU m7b Disrupted 0.165000 0.066000 0.010000
hsa-miR-548x-3p ttatcaAGTTTTTtcatga
 0 UAAAAACU m7b Disrupted 0.165000 0.066000 No effect
hsa-miR-5582-3p ttatcAAGTTTTttcatga
 7
 UAAAACUU m7b Disrupted 0.177000 0.073000 No effect
hsa-miR-570-3p ttatcaagTGTTTTCatga
 2
 CGAAAACA m7b Created 0.184000 0.300000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr4:g.105239171T>C COSN6788953 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3065-5p cagacTTTGTTGttccatt
 0 UCAACAAA m7b Disrupted 0.197000 0.096000 0.020000
hsa-miR-3120-3p cagactTTGCTGTtccatt
 1
 CACAGCAA m7b Created -0.061000 -0.026000 No effect
hsa-miR-3529-3p cagactTTGTTGTTccatt
 0 AACAACAA m8a Disrupted 0.087000 0.006000 0.010000
hsa-miR-545-3p cagacTTTGCTGttccatt
 6
 UCAGCAAA m7b Created -0.077000 -0.002000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr4:g.105239846A>G COSN6788954 RK181_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3671 ttttgATTTGAagtggcag
 17
 AUCAAAUA m6b Created 0.179000 0.321000 No effect
hsa-miR-4762-5p ttttGATTTGaagtggcag
 0 CCAAAUCU m6b Created no TS 0.095000 -0.020000
hsa-miR-607 ttttgATTTGAAgtggcag
 5
 GUUCAAAU m7b Created 0.412000 0.617000 -0.030000

Mutation Mutation ID Sample Name Cancer Type
chr4:g.105239848A>T COSN6788955 RK181_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3064-3p ttgatttaaTGTGGCAggc
 2
 UUGCCACA m7b (m6c->m7b) -0.424000 -0.482000 No effect
hsa-miR-4252 ttgatttaaAGTGGCaggc
 1
 GGCCACUG m6b Disrupted -0.011000 no TS 1.630000

Mutation Mutation ID Sample Name Cancer Type
chr4:g.105240759C>G COSN15076678 SM-4B296 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1184 cctgactCTGCAGGatttt
 1
 CCUGCAGC m7a Created -0.151000 -0.151000 No effect
hsa-miR-2467-3p cctgaCTCTGCaggatttt
 0 AGCAGAGG m6b Created no TS 0.035000 No effect
hsa-miR-3158-5p cctgacTCTGCAGGatttt
 2
 CCUGCAGA m8a Created -0.011000 0.015000 -0.300000
hsa-miR-3678-3p cctgaCTCTGCAGgatttt
 0 CUGCAGAG m8a Created no TS 0.030000 -5.730000
hsa-miR-3690 cctgactcTCCAGGatttt
 2
 ACCUGGAC m6b Disrupted -0.030000 no TS 11.620000
hsa-miR-4254 cctgactCTCCAGGatttt
 2
 GCCUGGAG m7b Disrupted -0.093000 no TS No effect
hsa-miR-5192 cctgACTCTCCaggatttt
 0 AGGAGAGU m7b Disrupted 0.013000 -0.005000 0.460000
hsa-miR-759 cctgACTCTGCaggatttt
 5
 GCAGAGUG m7a Created 0.044000 0.044000 -3.460000

Mutation Mutation ID Sample Name Cancer Type
chr4:g.105241337A>C ICGC_1326252 TCGA-AX-A06H-01A-11D-A122-09 UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1267 tatcTCAACAGagcaaatt
 16
 CCUGUUGA m7b Disrupted -0.038 no TS 0.02
hsa-miR-3194-3p tatctcaaCAGAGCaaatt
 0 AGCUCUGC m6b Disrupted -0.037 no TS 0.05
hsa-miR-367-5p tatctCAACAGagcaaatt
 0 ACUGUUGC m6b Disrupted 0.026 0.009 No effect
hsa-miR-423-3p tatctcaACCGAGCaaatt
 0 AGCUCGGU m7b Created no TS -0.338 -2.65
hsa-miR-5691 tatctcaaCAGAGCAAatt
 0 UUGCUCUG m8a Disrupted -0.195 -0.066 No effect

Mutation Mutation ID Sample Name Cancer Type
chr4:g.105241954C>T COSN8489862 J32_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3613-3p ttttTTTTTTGctatcaat
 4
 ACAAAAAA m7b Created 0.254000 0.298000 No effect
hsa-miR-548p ttttttTTTTGCTAtcaat
 6
 UAGCAAAA m8a Created 0.234000 0.180000 -0.020000

Mutation Mutation ID Sample Name Cancer Type
chr4:g.105241964C>A COSN8489863 J54_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4679 gctatcaATCACAGgtata
 5
 UCUGUGAU m7b Disrupted -0.092000 0.016000 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr4:g.105242512T>C COSN5548046 RK155_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3182 tttatgtttCAGAAGactg
 2
 GCUUCUGU m6b Created 0.077000 -0.015000 -0.010000
hsa-miR-4762-3p tttatgttTCAGAAGactg
 2
 CUUCUGAU m7a Created 0.133000 0.133000 No effect
hsa-miR-4766-5p tttatgTTTCAGAagactg
 2
 UCUGAAAG m7a Created 0.247000 0.194000 No effect
hsa-miR-4799-5p tttatgtTTTAGAagactg
 4
 AUCUAAAU m6b Disrupted -0.006000 no TS No effect
hsa-miR-494 tttATGTTTCAgaagactg
 0 UGAAACAU m8a Created 0.121000 -0.065000 No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
105238341 rs112106085 T T hsa-miR-3120-3p
1
 gTGCTGTAtcaat
 Disrupted
N
 -0.061
C hsa-miR-103a-3p
hsa-miR-107
1
1
 gTGCTGCAtcaat
gTGCTGCAtcaat
 Created
Created
N
N
 -0.111
-0.111
105238425 rs114672787 T T hsa-miR-1305
hsa-miR-607
2
2
 atttctTTGAAAA
atttcTTTGAAAa
 Disrupted
Disrupted
N
N
 0.099
0.089
G hsa-miR-27a-3p
hsa-miR-27b-3p
hsa-miR-5096
hsa-miR-513a-5p
2
2
2
2
 atttCTGTGAAaa
atttCTGTGAAaa
atttctGTGAAAA
atttCTGTGAAaa
 Created
Created
Created
Created
N
N
N
N
 -0.026
-0.029
0.051
-0.028
105238693 rs75543055 - G hsa-miR-132-5p
hsa-miR-617
0 ctCCACGGAagtc
ctccacGGAAGTC
 Unknown
Unknown
N
N
 -0.094
-0.023
A hsa-miR-134-3p
hsa-miR-3182
hsa-miR-6505-3p
hsa-miR-7114-5p
hsa-miR-7847-3p
0 ctCCACAGAagtc
ctccACAGAAGtc
ctccacAGAAGTC
cTCCACAGAagtc
CTCCACAgaagtc
 Unknown
Unknown
Unknown
Unknown
Unknown
N
N
N
N
N
 0.004
0.066
0.034
-0.058
0.007
105238838 rs186865609 A A hsa-miR-488-3p
2
 CTTTCAAtgtact
 Disrupted
N
 0.083
G hsa-miR-4766-5p
hsa-miR-6757-3p
2
2
 CTTTCAGtgtact
ctttCAGTGTAct
 Created
Created
N
N
 0.102
0.038
105239072 rs142771063 - - hsa-miR-3613-3p
1
 ttttggttttgTTTTTTGttttttttttttg
 Unknown
N
 -0.13
TGTTTTTTTG
105239072 rs201751306 T T hsa-miR-3613-3p
1
 tgTTTTTTGtttt
 Disrupted
N
 0.124
105239081 rs77594911 - - hsa-miR-3613-3p
21
 ttttttgttttttTTTTTTGtttttta
 Unknown
N
 -0.1
GTTTTTTT
105239082 rs72665940 T T hsa-miR-3613-3p
21
 tttttTTTTTTGt
 Disrupted
N
 -0.028
105239087 rs74280052 - - hsa-miR-3613-3p
0 tttttTTTTTTGttttttagcag
 Unknown
N
 -0.007
GTTTTT hsa-miR-548aa
hsa-miR-548ac
hsa-miR-548ap-3p
hsa-miR-548d-3p
hsa-miR-548h-3p
hsa-miR-548t-3p
hsa-miR-548z
1
1
1
1
1
1
1
 ttttttttttTGGTTTTtttttttagcag
tttttttttttGGTTTTTttttttagcag
ttttttttttTGGTTTTtttttttagcag
tttttttttttGGTTTTTttttttagcag
tttttttttttGGTTTTTttttttagcag
ttttttttttTGGTTTTtttttttagcag
tttttttttttGGTTTTTttttttagcag
 Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
N
N
N
N
N
N
N
 0.01
0.034
0.01
0.062
0.043
0.01
0.043
105239087 rs78302349 G G hsa-miR-3613-3p
21
 TTTTTTGtttttt
 Disrupted
N
 0.112
105239480 rs183534271 A A hsa-miR-4803
2
 TATGTTAtagaga
 Disrupted
N
 0.059
G hsa-miR-1283
hsa-miR-3529-3p
hsa-miR-4684-5p
2
2
2
 tatgTTGTAGAga
taTGTTGTAgaga
tatgttGTAGAGA
 Created
Created
Created
N
N
N
 0.081
0.092
0.034
105239851 rs148461433 G G hsa-miR-4252
hsa-miR-4722-3p
hsa-miR-4763-5p
hsa-miR-6727-3p
1
1
1
1
 taaAGTGGCAggc
taaagTGGCAGGc
taaagtGGCAGGC
taaagTGGCAGGc
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.011
-0.05
-0.143
-0.05
A hsa-miR-5089-3p
1
 taaAGTAGCAggc
 Created
N
 -0.081
105240470 rs144985901 C C hsa-miR-105-5p
hsa-miR-511-5p
hsa-miR-6830-3p
hsa-miR-7853-5p
8
2
2
11
 caaagaCATTTGA
cAAAGACAtttga
cAAAGACAtttga
caaagaCATTTGA
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 0.087
0.054
0.061
0.09
T hsa-miR-3671
8
 caaagaTATTTGA
 Created
N
 0.027
105240734 rs183982411 C C hsa-miR-185-3p
hsa-miR-367-5p
hsa-miR-4675
hsa-miR-4684-3p
hsa-miR-4687-3p
hsa-miR-4741
3
2
2
2
4
2
 ttgcaaCAGCCCC
ttGCAACAGcccc
ttgcaACAGCCCc
TTGCAACAgcccc
ttgcAACAGCCcc
ttgcaACAGCCCc
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
 -0.113
0.009
-0.083
0.071
0.06
-0.018
T hsa-miR-25-3p
hsa-miR-32-5p
hsa-miR-363-3p
hsa-miR-367-3p
hsa-miR-4489
hsa-miR-92a-3p
hsa-miR-92b-3p
2
2
2
2
3
2
2
 tTGCAATAgcccc
tTGCAATAgcccc
tTGCAATAgcccc
tTGCAATAgcccc
ttgcaaTAGCCCC
tTGCAATAgcccc
tTGCAATAgcccc
 Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
 0.101
0.091
0.094
0.087
-0.136
0.097
0.097
105241953 rs201078423 - TC 0
- hsa-miR-3613-3p
hsa-miR-548p
5
1
 tTTTTTTGctatc
tttTTTTGCTAtc
 Unknown
Unknown
N
N
 0.048
-0.069

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