SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001059
Gene Symbol: TACR3
Description: Homo sapiens tachykinin receptor 3 (TACR3), mRNA.
Gene Location: chr4(-):104510624-104640973
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Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr4:g.103589551A>G COSN9582608 AOCS-063-1-3 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr4:g.103589552C>A COSN9582609 AOCS-063-1-3 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2681-5p agctatGGTAAAAttgaga
 2
 GUUUUACC m7b Created 0.000000 -0.294000 -1.730000
hsa-miR-590-3p agctatggTAAAATTgaga
 0 UAAUUUUA m7b Created no TS 0.047000 -0.030000
hsa-miR-591 agctATGGTCaaattgaga
 2
 AGACCAUG m6b Disrupted -0.157000 no TS 5.850000

Mutation Mutation ID Sample Name Cancer Type
chr4:g.103589662A>G COSN8489858 308_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2681-5p tgaGGTAAAAgattagtgt
 2
 GUUUUACC m7b (m7b->m6c) 0.000000 no TS No effect
hsa-miR-362-5p tgaggtaAAGGATTagtgt
 0 AAUCCUUG m7a Created NA NA -8.750000
hsa-miR-500a-5p tgaggtaAAGGATTAgtgt
 0 UAAUCCUU m8a Created no TS -0.302000 -10.890000
hsa-miR-500b tgaggtaAAGGATTagtgt
 0 AAUCCUUG m7a Created NA NA -6.850000
hsa-miR-501-5p tgaggtAAAGGATTagtgt
 0 AAUCCUUU m8a Created no TS -0.149000 -8.450000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
103589557 rs201125726 A A hsa-miR-22-3p
hsa-miR-591
8
15
 GCAGCTAtggtca
gcagctATGGTCA
 Disrupted
Disrupted
N
N
 -0.232
-0.157
G hsa-miR-140-3p
1
 gcagCTGTGGTca
 Created
N
 -0.199
103589664 rs202224331 A A hsa-miR-2681-5p
hsa-miR-4777-3p
2
2
 gaGGTAAAAgatt
GAGGTAAaagatt
 Disrupted
Disrupted
N
N
 No Change
No Change

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