SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001122824
Gene Symbol:	TACC1
Description:	Homo sapiens transforming, acidic coiled-coil containing protein 1 (TACC1), transcript variant 2, mRNA.
Gene Location:	chr8(+):38644721-38710546
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.38848133C>G			COSN9262108		C0023T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.38848273A>G			COSN7671704		PCSI_0083_Pa_P_526		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-205-5p	cccctATGAAGGttccctt	0	UCCUUCAU	m7b	Disrupted	-0.109000	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.38848493A>T			COSN4939923		PD4115a		[breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1248	tttataatcAAGAAGGggc	0	ACCUUCUU	m7b	(m7b->m6c)	-0.157000	-0.071000	0.120000
hsa-miR-4777-5p	tttataATCTAGAAggggc	2	UUCUAGAU	m8a	Created	-0.063000	-0.260000	-0.020000
hsa-miR-518d-5p	tttataaTCTAGAaggggc	2	CUCUAGAG	m6b	Created	-0.075000	-0.113000	-0.250000
hsa-miR-518e-5p	tttataaTCTAGAaggggc	2	CUCUAGAG	m6b	Created	-0.068000	-0.106000	-1.050000
hsa-miR-518f-5p	tttataaTCTAGAaggggc	2	CUCUAGAG	m6b	Created	-0.075000	-0.113000	-1.080000
hsa-miR-519a-5p	tttataaTCTAGAaggggc	2	CUCUAGAG	m6b	Created	-0.068000	-0.106000	-1.050000
hsa-miR-519b-5p	tttataaTCTAGAaggggc	2	CUCUAGAG	m6b	Created	-0.068000	-0.106000	-1.050000
hsa-miR-519c-5p	tttataaTCTAGAaggggc	2	CUCUAGAG	m6b	Created	-0.068000	-0.106000	-1.050000
hsa-miR-520c-5p	tttataaTCTAGAaggggc	2	CUCUAGAG	m6b	Created	-0.075000	-0.113000	-0.250000
hsa-miR-522-5p	tttataaTCTAGAaggggc	2	CUCUAGAG	m6b	Created	-0.068000	-0.106000	-1.050000
hsa-miR-523-5p	tttataaTCTAGAaggggc	2	CUCUAGAG	m6b	Created	-0.068000	-0.106000	-1.050000
hsa-miR-526a	tttataaTCTAGAaggggc	2	CUCUAGAG	m6b	Created	-0.075000	-0.113000	-0.250000
hsa-miR-526b-5p	tttataaTCAAGAaggggc	0	CUCUUGAG	m6b	Disrupted	-0.035000	no TS	0.030000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.38848576C>T			COSN8518896		3844_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-211-3p	gctctttTCCCTGaagcat	2	GCAGGGAC	m6b	Disrupted	-0.118000	no TS	0.010000
hsa-miR-3123	gctcttTTCTCTGaagcat	0	CAGAGAAU	m7a	Created	NA	NA	No effect
hsa-miR-3127-5p	gctcttttCCCTGAagcat	3	AUCAGGGC	m6b	Disrupted	-0.332000	-0.215000	0.090000
hsa-miR-3919	gctcttTTCTCTGaagcat	2	GCAGAGAA	m7b	Created	0.044000	-0.129000	-3.720000
hsa-miR-4270	gctctttTCCCTGAagcat	2	UCAGGGAG	m7a	Disrupted	-0.099000	no TS	0.100000
hsa-miR-4441	gctctttTCCCTGaagcat	2	ACAGGGAG	m6b	Disrupted	-0.099000	no TS	5.900000
hsa-miR-4668-5p	gctcTTTTCCCTgaagcat	2	AGGGAAAA	m8a	Disrupted	-0.204000	-0.177000	0.110000
hsa-miR-4756-3p	gctctttTCTCTGaagcat	2	CCAGAGAU	m6b	Created	0.036000	-0.030000	-0.010000
hsa-miR-5584-5p	gctctTTTCCCTGaagcat	2	CAGGGAAA	m8a	Disrupted	-0.226000	-0.139000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.38848592G>A			COSN8083639		8047856		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-550b-3p	catagtcaAGTAAGAactg	0	UCUUACUC	m7a	Disrupted	-0.058000	-0.029000	0.030000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.38850341A>G			COSN9262109		C0009T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1200	tacagaTCAGGAGaatata	0	CUCCUGAG	m7a	Created	NA	NA	-0.230000
hsa-miR-1976	tacagatCAGGAGaatata	2	CCUCCUGC	m6b	Created	0.018000	0.020000	-0.080000
hsa-miR-378a-5p	tacagaTCAGGAGaatata	0	CUCCUGAC	m7a	Created	NA	NA	-0.160000
hsa-miR-4279	tacagatcAGGAGAatata	0	CUCUCCUC	m6b	Created	-0.083000	-0.071000	-0.150000
hsa-miR-4768-5p	tacagatcaAGAGAATata	0	AUUCUCUC	m7a	(m7a->m6b)	0.048000	0.048000	-0.040000
hsa-miR-526b-5p	tacagaTCAAGAGaatata	0	CUCUUGAG	m7a	Disrupted	-0.035000	-0.035000	0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.38850824A>G			COSN6695084		RK190_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-5581-5p	ggaaagtaGAAGGCagctg	2	AGCCUUCC	m6b	Disrupted	0.036000	0.011000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.38850872G>A			COSN14630090		8068539		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-421	ggtgatcCTGTTGAgattc	2	AUCAACAG	m7b	Disrupted	0.113000	0.076000	0.800000
hsa-miR-4709-5p	ggtgatcCTGTTGagattc	4	ACAACAGU	m6b	Disrupted	0.135000	0.085000	0.020000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
38848122	rs71721705	-	-	hsa-miR-3191-5p hsa-miR-4768-5p hsa-miR-6728-3p hsa-miR-6809-3p hsa-miR-6833-3p	9 8 11 8 8	gCAGAGAAaaaaa gcAGAGAAAaaaa GCAGAGAaaaaaa gcAGAGAAAaaaa gcAGAGAAAaaaa	Unknown Unknown Unknown Unknown Unknown	N N N N N	0.001 0.002 0.001 0.002 0.002
			A
38848498	rs34188402	-	G	hsa-miR-1225-3p hsa-miR-1248 hsa-miR-3127-3p hsa-miR-5088-3p hsa-miR-6756-3p hsa-miR-6769a-3p	3 4 2 5 2 2	caagaaGGGGCTC cAAGAAGGggctc caaGAAGGGGctc caAGAAGGGgctc caaGAAGGGGctc caagaAGGGGCTc	Unknown Unknown Unknown Unknown Unknown Unknown	N N N N N N	-0.268 0.01 -0.211 0.017 -0.202 -0.234
			-	hsa-miR-1233-3p hsa-miR-129-1-3p hsa-miR-129-2-3p hsa-miR-6886-3p	2 5 5 2	caagaAGGGCTC caagAAGGGCTc caagAAGGGCTc caaGAAGGGCtc	Unknown Unknown Unknown Unknown	N N N N	-0.231 -0.167 -0.167 -0.206
38849277	rs144004105	A	A	hsa-miR-1915-5p hsa-miR-4279 hsa-miR-502-5p hsa-miR-6841-3p	2 3 2 2	GCAAGGAgaaggt gcaAGGAGAAggt GCAAGGAgaaggt GCAAGGAgaaggt	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.015 0.037 -0.034 -0.064
			C	hsa-miR-6880-3p	3	gcAAGGCGAaggt	Created	N	-0.106
38850501	rs1802271	G	G	hsa-miR-1236-3p hsa-miR-3182 hsa-miR-4753-3p hsa-miR-4768-5p hsa-miR-6515-3p hsa-miR-6809-3p hsa-miR-6833-3p	2 2 2 2 2 2 2	acaGAAGAGAaaa ACAGAAGAgaaaa acagAAGAGAAaa acagaAGAGAAAa acaGAAGAGAaaa acagAAGAGAAAa acagaAGAGAAAa	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N	0.071 0.048 0.096 0.122 0.067 0.233 0.122
			T	hsa-miR-26a-1-3p hsa-miR-26a-2-3p hsa-miR-4482-3p hsa-miR-4778-5p hsa-miR-6731-3p hsa-miR-7159-3p	2 2 2 2 2 2	acAGAATAGAaaa acAGAATAGAaaa acagAATAGAAAa ACAGAATAgaaaa acaGAATAGAaaa acagaATAGAAAa	Created Created Created Created Created Created	N N N N N N	0.118 0.118 0.257 0.113 0.081 0.147
38850823	rs35135341	G	G	hsa-miR-138-1-3p hsa-miR-4297 hsa-miR-5581-5p	3 5 5	aAAGTAGAaggca aaagtaGAAGGCA aaagtaGAAGGCA	Disrupted Disrupted Disrupted	N N N	0.09 0.014 0.025
38852177	rs114058139	G	G	hsa-miR-5582-5p	18	atttcTGTGCCTc	Disrupted	N	-0.118
			C	hsa-miR-1827 hsa-miR-1910-3p hsa-miR-3919 hsa-miR-539-5p hsa-miR-6511a-5p	19 18 15 12 18	atttctCTGCCTC atttcTCTGCCTc atTTCTCTGcctc ATTTCTCtgcctc atttcTCTGCCTc	Created Created Created Created Created	N N N N N	-0.15 -0.131 -0.045 0.061 -0.112

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