SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_006282
Gene Symbol: STK4
Description: Homo sapiens serine/threonine kinase 4 (STK4), mRNA.
Gene Location: chr20(+):43595119-43708593
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr20:g.45075504C>G COSN14506778 8070208 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-330-3p aataGCTTTGaattgttct
 3
 GCAAAGCA m6b Created -0.027000 -0.116000 -0.920000

Mutation Mutation ID Sample Name Cancer Type
chr20:g.45076618C>A COSN8345872 0006_CRUK_PC_0006_T3_DNA [prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1231 tatagCAGACAagcaccca
 1
 GUGUCUGG m6b Disrupted 0.045000 no TS 0.450000
hsa-miR-3140-3p tatagcagAAAAGCaccca
 0 AGCUUUUG m6b Created no TS 0.137000 -0.860000
hsa-miR-346 tataGCAGACAagcaccca
 1
 UGUCUGCC m7a Disrupted -0.023000 no TS No effect
hsa-miR-3655 tatagcaGACAAGCaccca
 0 GCUUGUCG m7a Disrupted NA NA 0.070000
hsa-miR-4288 tataGCAGACAAgcaccca
 1
 UUGUCUGC m8a Disrupted -0.052000 no TS 0.050000
hsa-miR-544a tataGCAGAAaagcaccca
 0 AUUCUGCA m6b Created no TS 0.046000 -0.310000
hsa-miR-632 tataGCAGACAagcaccca
 1
 GUGUCUGC m7b Disrupted -0.063000 no TS 2.930000
hsa-miR-636 tatagcagaCAAGCACcca
 2
 UGUGCUUG m7b (m7b->m6c) 0.051000 no TS -0.040000

Mutation Mutation ID Sample Name Cancer Type
chr20:g.45076688A>G COSN1873527 RK075_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4426 catagagCCATCTTCctgc
 3
 GAAGAUGG m8a Disrupted -0.063000 -0.167000 No effect
hsa-miR-4647 catagagCCATCTTCctgc
 3
 GAAGAUGG m8a Disrupted -0.147000 -0.213000 0.050000
hsa-miR-4662b catagagCCATCTTcctgc
 3
 AAAGAUGG m7b Disrupted -0.090000 -0.194000 No effect
hsa-miR-7-5p catagagccGTCTTCCtgc
 0 UGGAAGAC m7b (m6c->m7b) no TS 0.077000 -0.010000
hsa-miR-4426 catagagCCATCTTCctgc
 2
 GAAGAUGG m8a Disrupted -0.063 -0.167 No effect
hsa-miR-4647 catagagCCATCTTCctgc
 2
 GAAGAUGG m8a Disrupted -0.147 -0.213 0.05
hsa-miR-4662b catagagCCATCTTcctgc
 2
 AAAGAUGG m7b Disrupted -0.09 -0.194 No effect
hsa-miR-7-5p catagagccGTCTTCCtgc
 0 UGGAAGAC m7b (m6c->m7b) no TS 0.077 -0.01

Mutation Mutation ID Sample Name Cancer Type
chr20:g.45076733C>T COSN4970257 SS6003119 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2681-3p gagCCATGATtgggttgca
 0 UAUCAUGG m7b (m6b->m7b) -0.048000 0.061000 0.160000
hsa-miR-3130-5p gagccatgACTGGGTtgca
 2
 UACCCAGU m7b Disrupted 0.005000 -0.021000 No effect
hsa-miR-4482-5p gagccatgACTGGGTTgca
 2
 AACCCAGU m8a Disrupted 0.005000 -0.011000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr20:g.45077457A>G ICGC_B27E5322-2A78-11E2-8335-12FD496BB9B8 CPCG_0102_Pr_P_P2 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-25-3p ggctggaGTGCAATGgcac
 0 CAUUGCAC m8a Created no TS 0.117 -0.33
hsa-miR-32-5p ggctggaGTGCAATggcac
 0 UAUUGCAC m7b Created no TS 0.117 No effect
hsa-miR-363-3p ggctggaGTGCAATggcac
 0 AAUUGCAC m7b Created no TS 0.098 -0.08
hsa-miR-367-3p ggctggaGTGCAATggcac
 0 AAUUGCAC m7b Created no TS 0.107 -1.6
hsa-miR-508-5p ggCTGGAGTAcaatggcac
 1
 UACUCCAG m8a (m8a->m7a) 0.09 0.116 4.42
hsa-miR-92a-3p ggctggaGTGCAATggcac
 0 UAUUGCAC m7b Created no TS 0.117 -0.73
hsa-miR-92b-3p ggctggaGTGCAATggcac
 0 UAUUGCAC m7b Created no TS 0.117 -0.09

Mutation Mutation ID Sample Name Cancer Type
chr20:g.45077650C>G ICGC_B27E57FA-2A78-11E2-8335-12FD496BB9B8 CPCG_0102_Pr_P_P2 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4302 cctccCACACTGctgggat
 1
 CCAGUGUG m7b Disrupted 0.126 no TS 0.02
hsa-miR-4318 cctcCCACAGTGctgggat
 0 CACUGUGG m8a Created no TS 0.105 -0.01
hsa-miR-4519 cctcccaCACTGCTGggat
 1
 CAGCAGUG m8a Disrupted -0.016 -0.049 1.72
hsa-miR-4530 cctcccacaCTGCTGGGat
 0 CCCAGCAG m8a (m8a->m7b) -0.062 -0.034 0.11

Mutation Mutation ID Sample Name Cancer Type
chr20:g.45079185T>C ICGC_B27E5D18-2A78-11E2-8335-12FD496BB9B8 CPCG_0102_Pr_P_P2 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3135b actgcaCTCCAGCCtgggt
 0 GGCUGGAG m8a Created no TS -0.15 -0.1
hsa-miR-3652 actgcacTCCAGCCtgggt
 0 CGGCUGGA m7b Created no TS -0.077 No effect
hsa-miR-4430 actgcacTCCAGCCTgggt
 0 AGGCUGGA m8a Created no TS -0.058 -0.01
hsa-miR-5586-3p actgCACTCTagcctgggt
 1
 CAGAGUGA m6b Disrupted 0.032 0.05 No effect


Mutation Mutation ID Sample Name Cancer Type
chr20:g.45079581G>C COSN4907921 CPCG_0006_Pr_P_F0 [prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr20:g.45079843T>G COSN9130030 AOCS-161-1-9 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
45077013 rs6031974 G G hsa-miR-1271-3p
hsa-miR-33b-3p
hsa-miR-515-3p
hsa-miR-519e-3p
hsa-miR-550a-3-5p
hsa-miR-550a-5p
10
10
10
10
10
10
 atatCAGGCACtg
atatcAGGCACTg
atatcAGGCACTg
atatcAGGCACTg
atatCAGGCACtg
atatCAGGCACtg
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
 -0.076
-0.008
-0.008
-0.026
-0.095
-0.095
A hsa-miR-1273e
hsa-miR-520f-3p
hsa-miR-636
4
10
10
 ataTCAAGCActg
atatcAAGCACTg
atatCAAGCACtg
 Created
Created
Created
N
N
N
 -0.011
0.037
-0.021
45077676 rs142285124 C
T hsa-miR-4519
hsa-miR-5693
hsa-miR-6081
2
2
2
 agcCACTGCTcct
aGCCACTGctcct
agccaCTGCTCCt
 Created
Created
Created
N
N
N
 0.078
0.007
-0.011
45078869 rs186509849 C C hsa-miR-219b-5p
hsa-miR-2681-3p
hsa-miR-433-3p
4
9
1
 cGACATCAtgata
cgacatCATGATA
cgacATCATGAta
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.035
0.028
0.012
G hsa-miR-136-3p
hsa-miR-96-3p
1
3
 cgacatGATGATA
cgACATGATgata
 Created
Created
N
N
 -0.003
0.018
45079512 rs6130747 T T hsa-miR-4426
hsa-miR-4647
hsa-miR-4662b
hsa-miR-6890-5p
3
3
3
4
 accCCATCTTttc
accCCATCTTttc
accCCATCTTttc
ACCCCATcttttc
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.064
-0.101
-0.101
-0.182
G hsa-miR-320a
hsa-miR-320b
hsa-miR-320c
hsa-miR-320d
hsa-miR-320e
hsa-miR-4429
hsa-miR-4731-5p
hsa-miR-7155-5p
3
3
3
3
3
3
3
4
 acccCAGCTTTtc
acccCAGCTTTtc
acccCAGCTTTtc
acccCAGCTTTtc
accCCAGCTTttc
acccCAGCTTTtc
aCCCCAGCttttc
ACCCCAGcttttc
 Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
 -0.067
-0.067
-0.067
-0.067
-0.149
-0.067
-0.243
-0.165

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