SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_004226
Gene Symbol:	STK17B
Description:	Homo sapiens serine/threonine kinase 17b (STK17B), mRNA.
Gene Location:	chr2(-):196998306-197036336
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.196133644A>T			COSN9870756		C0031T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-31-5p	gcatgtTCTTGCCTttgac	0	AGGCAAGA	m8a	Created	no TS	-0.277000	-2.180000
hsa-miR-548an	gcatgttctTGCCTTTgac	0	AAAAGGCA	m7b	(m6b->m7b)	-0.020000	-0.161000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.196134116C>T			COSN6162630		RK195_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-198	catTCTGGACagctcacaa	2	GGUCCAGA	m7b	(m7b->m6c)	-0.322000	no TS	0.010000
hsa-miR-3160-3p	cattctggaCAGCTCacaa	2	AGAGCUGA	m6b	Disrupted	-0.021000	0.089000	0.020000
hsa-miR-4487	cattctggaCAGCTCacaa	2	AGAGCUGG	m6b	Disrupted	-0.024000	0.064000	1.090000

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.196134376A>C			COSN9870757		C0031T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1256	tgagaatctAATGCCatgg	2	AGGCAUUG	m6b	Disrupted	-0.060000	no TS	No effect
hsa-miR-3622b-5p	tgagaatctCATGCCatgg	6	AGGCAUGG	m6b	Created	-0.420000	-0.490000	No effect
hsa-miR-376a-5p	tgaGAATCTAatgccatgg	2	GUAGAUUC	m7b	(m7b->m6c)	0.077000	0.129000	No effect
hsa-miR-4760-5p	tgagAATCTAAtgccatgg	2	UUUAGAUU	m7b	Disrupted	0.288000	0.214000	0.020000
hsa-miR-5186	tgagAATCTCatgccatgg	0	AGAGAUUG	m6b	Created	no TS	0.000000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.196134886C>T			COSN6162631		RK081_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-548c-3p	gattcaATTTTTactcttt	2	CAAAAAUC	m6b	Created	1.289000	1.507000	-0.170000

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.196135733T>C			COSN1816924		RK165_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1227	gcaGTGGCACGatctcagc	8	CGUGCCAC	m8a	Created	-0.143000	-0.171000	-1.940000
hsa-miR-5694	gcagtggcATGATCTcagc	1	CAGAUCAU	m7b	Disrupted	0.126000	-0.014000	0.060000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
196135130	rs147391739	A	A	hsa-miR-511-5p hsa-miR-548c-3p hsa-miR-6830-3p	2 11 2	AAAGACAttttta aaagacATTTTTA AAAGACAttttta	Disrupted Disrupted Disrupted	N N N	-0.031 0.209 0.04
196135731	rs7559080	A	A	hsa-miR-5694	2	ggcATGATCTcag	Disrupted	N	0.14
			G	hsa-miR-4329 hsa-miR-4786-5p hsa-miR-591 hsa-miR-6502-3p hsa-miR-6872-3p hsa-miR-769-5p	2 2 2 2 2 2	ggcatgGTCTCAG ggcaTGGTCTCAg ggCATGGTCtcag ggcATGGTCTcag GGCATGGtctcag ggcatGGTCTCAg	Created Created Created Created Created Created	N N N N N N	0.096 0.028 0.073 0.12 -0.027 0.033

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