SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_152996
Gene Symbol:	ST6GALNAC3
Description:	Homo sapiens ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (ST6GALNAC3), transcript variant 2, mRNA.
Gene Location:	chr1(+):76540388-77096669
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.76629124G>T			0_35				Lung cancer
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.76629377C>T			COSN7282152		8031544		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-544b	agCCTCAGGTcattgccta	9	ACCUGAGG	m8a	(m7a->m8a)	-0.139000	-0.167000	-0.810000
hsa-miR-631	agcctCAGGTCattgccta	0	AGACCUGG	m6b	Created	no TS	-0.111000	-0.050000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.76629468T>C			COSN195006		PD4116a		[breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-138-1-3p	tgggccAAGTAGCaaatct	0	GCUACUUC	m7a	Disrupted	NA	NA	0.430000
hsa-miR-138-1-3p	tgggccAAGTAGCaaatct	0	GCUACUUC	m7a	Disrupted	NA	NA	0.43

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.76629707C>T			COSN8638738		2275_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-19a-5p	ccaacaacaCAAAACTata	0	AGUUUUGC	m7a	(m7a->m6b)	NA	NA	0.920000
hsa-miR-19b-1-5p	ccaacaacaCAAAACTata	0	AGUUUUGC	m7a	(m7a->m6b)	NA	NA	4.750000
hsa-miR-19b-2-5p	ccaacaacaCAAAACTata	0	AGUUUUGC	m7a	(m7a->m6b)	NA	NA	3.140000
hsa-miR-2113	ccaacaaCACAAAactata	2	AUUUGUGC	m6b	Disrupted	0.007000	-0.008000	0.020000
hsa-miR-4781-3p	ccaaCAACATaaaactata	0	AAUGUUGG	m6b	Created	no TS	-0.004000	0.440000
hsa-miR-5010-3p	ccaacaACACAAAActata	2	UUUUGUGU	m8a	Disrupted	-0.157000	-0.105000	0.200000
hsa-miR-599	ccaacaACACAAaactata	2	GUUGUGUC	m6b	Disrupted	-0.044000	-0.036000	0.600000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.76629741G>A			COSN1457781		RK054_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4482-3p	tgaAATAGAAAcagcaaag	10	UUUCUAUU	m8a	Created	-0.043000	-0.019000	No effect
hsa-miR-626	tgaaatagAGACAGCaaag	1	AGCUGUCU	m7b	Disrupted	-0.256000	no TS	0.010000
hsa-miR-4482-3p	tgaAATAGAAAcagcaaag	0	UUUCUAUU	m8a	Created	-0.043	-0.019	No effect
hsa-miR-626	tgaaatagAGACAGCaaag	0	AGCUGUCU	m7b	Disrupted	-0.256	no TS	0.01

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.76630385A>G			COSN15174732		LP6005334-DNA_C02		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1238	gacaacagGAGGAAatgaa	2	CUUCCUCG	m6b	Disrupted	-0.081000	-0.005000	0.770000
hsa-miR-1976	gacaaCAGGAGGaaatgaa	0	CCUCCUGC	m7a	Disrupted	NA	NA	11.910000
hsa-miR-3679-3p	gacaacaGGGGGAAatgaa	3	CUUCCCCC	m7b	Created	-0.121000	-0.455000	-6.560000
hsa-miR-4691-5p	gacaacaGGAGGAaatgaa	1	GUCCUCCA	m6b	Disrupted	-0.341000	-0.234000	No effect
hsa-miR-5193	gacaacAGGAGGAaatgaa	3	UCCUCCUC	m7a	Disrupted	-0.113000	no TS	0.570000
hsa-miR-660-3p	gacaaCAGGAGGaaatgaa	2	ACCUCCUG	m7b	Disrupted	-0.307000	no TS	0.570000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
76629746	rs180945320	C	C	hsa-miR-1251-3p hsa-miR-626 hsa-miR-6876-3p	8 1 1	agacaGCAAAGCA AGACAGCAaagca AGACAGCAaagca	Disrupted Disrupted Disrupted	N N N	-0.204 -0.256 -0.287
			T	hsa-miR-4693-5p	1	agACAGTAAagca	Created	N	-0.06

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