SomamiR DB

SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only All 6mer or longer seed matches

PolymiRTS Database

RefSeq ID:	NM_001135823
Gene Symbol:	SSPN
Description:	Homo sapiens sarcospan (Kras oncogene-associated gene) (SSPN), transcript variant 2, mRNA.
Gene Location:	chr12(+):26348268-26387708
Browse Associations

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.26231208A>G			9_95247		CRC-8-Tumor		Colorectal adenocarcinoma
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3163	tatTTTTATAtttttatga	0	UAUAAAAU	m7a	(m7a->m6a)	0.665	0.635	0.01
hsa-miR-4803	tatttTTATGTTtttatga	4	UAACAUAA	m7b	Created	no TS	-0.166	-0.6

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.26231642G>T			COSN14859945		LP2000108-DNA_A01		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-151a-3p	ttgcaaaAGTCTAGataac	0	CUAGACUG	m7a	Created	NA	NA	No effect
hsa-miR-4305	ttgcaaaaGTCTAGataac	0	CCUAGACA	m6b	Created	no TS	-0.106000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.26232291G>C			COSN7324737		8030032		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-2276	cttgaCTTGCAGggtagtt	1	UCUGCAAG	m7b	Created	-0.380000	-0.425000	-1.550000
hsa-miR-3691-3p	cttGACTTGGagggtagtt	12	ACCAAGUC	m7b	(m7b->m6b)	-0.093000	0.015000	0.050000
hsa-miR-5695	cttgaCTTGGAGggtagtt	3	ACUCCAAG	m7b	Disrupted	-0.183000	-0.162000	0.050000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.26232507T>A			COSN8707330		AOCS-143-1-0		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4275	gataaTAATTGagttcaat	9	CCAAUUAC	m6b	Disrupted	0.048000	-0.042000	No effect
hsa-miR-4680-5p	gataataatAGAGTTCaat	2	AGAACUCU	m7b	(m6c->m7b)	-0.018000	-0.103000	-0.080000
hsa-miR-4795-3p	gatAATAATAgagttcaat	2	AUAUUAUU	m7b	(m6b->m7b)	0.138000	0.254000	No effect
hsa-miR-618	gataataaTAGAGTTcaat	0	AAACUCUA	m7b	Created	no TS	-0.022000	No effect
hsa-miR-944	gatAATAATTgagttcaat	8	AAAUUAUU	m7b	(m7b->m6b)	0.679000	0.524000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.26232527G>A			COSN7324738		8016470		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4491	cgcctcTCCACATTgccta	0	AAUGUGGA	m8a	Created	no TS	0.032000	-2.230000
hsa-miR-4657	cgcctcTCCACATTgccta	0	AAUGUGGA	m8a	Created	no TS	0.032000	-0.880000
hsa-miR-658	cgcctCTCCGCattgccta	1	GGCGGAGG	m6b	Disrupted	-0.082000	no TS	0.080000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.26233145A>C			COSN8707331		AOCS-147-1-1		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-124-5p	atagTGAACACtacaagtt	0	CGUGUUCA	m7b	Disrupted	-0.093000	-0.066000	2.810000
hsa-miR-135b-3p	atagtgaaCCCTACAagtt	0	AUGUAGGG	m7b	Created	no TS	-0.162000	-0.070000
hsa-miR-142-3p	atagtgaACACTACAagtt	3	UGUAGUGU	m8a	Disrupted	-0.109000	no TS	4.370000
hsa-miR-296-3p	atagtgAACCCTacaagtt	0	GAGGGUUG	m6b	Created	-0.028000	-0.050000	-0.900000
hsa-miR-4255	atagtGAACACTacaagtt	0	CAGUGUUC	m7b	Disrupted	-0.215000	-0.172000	4.330000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.26233363C>T			COSN1146557		HX13T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-147a	atacacacaCACACACaca	0	GUGUGUGG	m7a	(m7a->m6b)	0.007000	0.007000	-0.600000
hsa-miR-223-5p	atacacacATACACacaca	0	CGUGUAUU	m6b	Created	0.185000	0.213000	No effect
hsa-miR-297	atacacACATACAcacaca	0	AUGUAUGU	m7b	Created	0.029000	-0.001000	-0.810000
hsa-miR-567	atacacACATACacacaca	0	AGUAUGUU	m6b	Created	0.041000	0.077000	-0.240000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.26233415G>T			COSN7324739		8062308		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-154-3p	ctattGTATGATTaaatca	2	AAUCAUAC	m8a	Disrupted	-0.059000	no TS	2.980000
hsa-miR-369-3p	ctattGTATTATTaaatca	0	AAUAAUAC	m8a	Created	no TS	0.011000	-2.320000
hsa-miR-374c-5p	ctatTGTATTATtaaatca	0	AUAAUACA	m8a	Created	no TS	-0.014000	No effect
hsa-miR-4666a-3p	ctATTGTATGattaaatca	1	CAUACAAU	m8a	(m8a->m7a)	-0.069000	-0.097000	No effect
hsa-miR-485-3p	ctatTGTATGAttaaatca	1	GUCAUACA	m7b	Disrupted	-0.072000	no TS	0.120000
hsa-miR-487a	ctattGTATGATTaaatca	2	AAUCAUAC	m8a	Disrupted	-0.078000	no TS	2.710000
hsa-miR-539-3p	ctatTGTATGATtaaatca	1	AUCAUACA	m8a	Disrupted	-0.091000	no TS	0.090000
hsa-miR-5692b	ctattgTATTATTaaatca	0	AAUAAUAU	m7a	Created	NA	NA	0.240000
hsa-miR-5692c	ctattgTATTATTaaatca	0	AAUAAUAU	m7a	Created	NA	NA	0.650000
hsa-miR-655	ctatTGTATTATtaaatca	0	AUAAUACA	m8a	Created	no TS	-0.023000	-1.270000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.26234072A>G			COSN5939759		RK163_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-320a	ggggtttcCAGCTTTacac	2	AAAAGCUG	m7b	Disrupted	-0.027000	0.035000	No effect
hsa-miR-320b	ggggtttcCAGCTTTacac	2	AAAAGCUG	m7b	Disrupted	-0.031000	0.031000	No effect
hsa-miR-320c	ggggtttcCAGCTTTacac	2	AAAAGCUG	m7b	Disrupted	-0.027000	0.035000	No effect
hsa-miR-320d	ggggtttcCAGCTTTacac	2	AAAAGCUG	m7b	Disrupted	-0.027000	0.035000	No effect
hsa-miR-320e	ggggtttCCAGCTTTacac	2	AAAGCUGG	m8a	Disrupted	-0.151000	no TS	No effect
hsa-miR-4429	ggggtttcCAGCTTTacac	2	AAAAGCUG	m7b	Disrupted	-0.035000	0.027000	No effect
hsa-miR-875-3p	ggggTTTCCAGctttacac	7	CCUGGAAA	m7b	Disrupted	-0.002000	no TS	No effect
hsa-miR-9-3p	ggggtttccAGCTTTAcac	2	AUAAAGCU	m7b	(m7b->m6c)	0.037000	0.065000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.26234639T>C			SSPN_E3_UTR_3		SJHYPO126_D		Hypodiploid_ALL
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-21-3p	cttTGGTGTTGtggattca	8	CAACACCA	m8a	Disrupted	-0.223	-0.041	3.56
hsa-miR-3591-3p	cttTGGTGTTgtggattca	8	AAACACCA	m7b	(m7b->m6b)	-0.26	-0.041	3.48
hsa-miR-5003-5p	ctttggTGTTGTGgattca	6	UCACAACA	m7b	Disrupted	-0.199	-0.051	5.78
hsa-miR-5092	ctttggtgtCGTGGATTca	0	AAUCCACG	m8a	(m7b->m8a)	no TS	-0.246	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.26234698T>C			COSN1568486		RK020_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3668	attTCTACATgtttgaggt	3	AAUGUAGA	m7b	(m7b->m6b)	-0.265000	-0.061000	1.600000
hsa-miR-3668	attTCTACATgtttgaggt	3	AAUGUAGA	m7b	(m7b->m6b)	-0.265	-0.061	1.6

**Germline mutations in target sites of miRNAs in somatic mutation table**
Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
26231197	rs115326344	A	A	hsa-miR-4272 hsa-miR-4275 hsa-miR-6074	1 1 9	taaTTGAATAttt TAATTGAatattt taatTGAATATtt	Disrupted Disrupted Disrupted	N N N	-0.074 -0.086 -0.199
26231197	rs115326344	A
26231435	rs114210444	-	G	hsa-miR-1228-3p hsa-miR-377-3p	5 7	gatGGTGTGAatg gatgGTGTGAAtg	Unknown Unknown	N N	-0.131 -0.107
26231435	rs114210444	-	A	hsa-miR-181c-3p hsa-miR-485-3p hsa-miR-539-3p	5 7 7	GATGGTAtgaatg gatgGTATGAAtg gatgGTATGAAtg	Unknown Unknown Unknown	N N N	-0.156 -0.074 -0.081
26232865	rs182271039	C	C	hsa-miR-147a hsa-miR-3689a-5p hsa-miR-3689b-5p hsa-miR-3689e hsa-miR-3689f hsa-miR-6818-5p hsa-miR-6867-5p	3 0 0 0 0 3 3	ttatcaCACACAA tTATCACAcacaa tTATCACAcacaa tTATCACAcacaa tTATCACAcacaa ttaTCACACAcaa ttatCACACACAa	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N	0.007 0.042 0.042 0.042 0.038 0.008 -0.044
26232865	rs182271039	C	T	hsa-miR-223-5p	3	ttatcATACACAa	Created	N	0.034
26232868	rs34141209	-	-	hsa-miR-147a hsa-miR-2113 hsa-miR-5010-3p hsa-miR-599 hsa-miR-6867-5p	3 4 3 3 3	tcaCACACAAaag tcacaCACAAAAg tcacACACAAAAg tcacACACAAAag tCACACACAaaag	Unknown Unknown Unknown Unknown Unknown	N N N N N	0.005 0.101 0.127 0.057 -0.044
26232868	rs34141209	-	A	hsa-miR-6818-5p	3	TCACACAAcaaaag	Unknown	N	-0.017
26233210	rs112544008	G	G	hsa-miR-4490	2	TTACCAGtaattc	Disrupted	N	-0.019
26233210	rs112544008	G	A	hsa-miR-944	1	ttaccAATAATTc	Created	N	0.248
26233351	rs11048437	C	C	hsa-miR-223-5p hsa-miR-511-3p	1 0	tatATACACAtac tataTACACATAc	Disrupted Disrupted	N N	0.038 0.05
26233351	rs11048437	C	T	hsa-miR-190a-3p hsa-miR-3924 hsa-miR-5011-5p	1 0 1	tATATATAcatac tatatATACATAc TATATATAcatac	Created Created Created	N N N	-0.007 0.053 0.125
26233355	rs34695916	C	T	hsa-miR-223-5p hsa-miR-297 hsa-miR-511-3p hsa-miR-567	0	tacacATACACAc tacACATACAcac TACACATAcacac tacACATACAcac	Created Created Created Created	N N N N	0.027 0.029 0.045 0.041
26233355	rs34695916	C	C	hsa-miR-6867-5p	0	taCACACACAcac	Disrupted	N	0.031
26233357	rs34295709	C	C	hsa-miR-223-5p hsa-miR-297 hsa-miR-567 hsa-miR-6867-5p	0	cacATACACAcac cACATACAcacac cACATACAcacac cacataCACACAC	Disrupted Disrupted Disrupted Disrupted	N N N N	0.007 0.029 0.041 0.045
26233357	rs34295709	C
26233357	rs35874267	-	CACA	hsa-miR-223-5p hsa-miR-297 hsa-miR-567 hsa-miR-6867-5p	0	atacacATACACAcacaca atacACATACAcacacaca atacACATACAcacacaca atacacataCACACACAca	Unknown Unknown Unknown Unknown	N N N N	0.011 0.01 0.005 0.021
26233357	rs35874267	-	-
26233357	rs72405848	-	CA	hsa-miR-223-5p hsa-miR-297 hsa-miR-567 hsa-miR-6867-5p	0	acacATACACAcaca acACATACAcacaca acACATACAcacaca acacataCACACACA	Unknown Unknown Unknown Unknown	N N N N	0.005 0.004 0.003 0.015
26233357	rs72405848	-	-
26233375	rs187365608	T	T	hsa-miR-190a-3p hsa-miR-5011-5p	2 2	cacATATATActa cacATATATActa	Disrupted Disrupted	N N	0.173 0.17
26233375	rs187365608	T	C	hsa-miR-297 hsa-miR-3924 hsa-miR-567	1 2 1	cACATACAtacta cacATACATActa cACATACAtacta	Created Created Created	N N N	-0.003 0.094 0.039
26234078	rs182064804	A	A	hsa-miR-320a hsa-miR-320b hsa-miR-320c hsa-miR-320d hsa-miR-4429 hsa-miR-9-3p	2 2 2 2 2 2	AGCTTTAcacttc AGCTTTAcacttc AGCTTTAcacttc AGCTTTAcacttc AGCTTTAcacttc AGCTTTAcacttc	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N	-0.073 -0.073 -0.073 -0.073 -0.073 -0.028
26234078	rs182064804	A	G	hsa-miR-130a-3p hsa-miR-130b-3p hsa-miR-19a-3p hsa-miR-19b-3p hsa-miR-301a-3p hsa-miR-301b hsa-miR-3666 hsa-miR-4295 hsa-miR-454-3p hsa-miR-518a-5p hsa-miR-519a-3p hsa-miR-519b-3p hsa-miR-519c-3p hsa-miR-527	2 2 2 2 2 2 2 2 2 2 2 2 2 2	agctTTGCACTtc agctTTGCACTtc agcTTTGCACttc agcTTTGCACttc agctTTGCACTtc agctTTGCACTtc agctTTGCACTtc agctTTGCACTtc agctTTGCACTtc agCTTTGCActtc agcttTGCACTTc agcttTGCACTTc agcttTGCACTTc agCTTTGCActtc	Created Created Created Created Created Created Created Created Created Created Created Created Created Created	N N N N N N N N N N N N N N	-0.113 -0.132 -0.04 -0.04 -0.085 -0.085 -0.094 -0.085 -0.104 -0.034 -0.091 -0.091 -0.091 -0.034
26234511	rs74072108	T	T	hsa-miR-3646	4	caTTCATTTggat	Disrupted	N	-0.02
26234511	rs74072108	T	C	hsa-miR-1257 hsa-miR-3691-3p	5 4	CATTCACttggat cattcACTTGGAt	Created Created	N N	-0.171 -0.125

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Somatic mutations that impact miRNA target sites

Germline mutations in target sites of miRNAs in somatic mutation table

Genome Browser