SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_000348
Gene Symbol: SRD5A2
Description: Homo sapiens steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (SRD5A2), mRNA.
Gene Location: chr2(-):31749655-31806040
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr2:g.31524800A>T COSN14647149 ASHPC_0002_Pa_P_4 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4282 catggAAATTTTtgtcttc
 0 UAAAAUUU m7b Created no TS 0.102000 -2.670000
hsa-miR-513a-3p catgGAAATTTttgtcttc
 2
 UAAAUUUC m7b Created -0.035000 -0.047000 -4.680000
hsa-miR-513c-3p catgGAAATTTttgtcttc
 2
 UAAAUUUC m7b Created -0.035000 -0.047000 -6.150000
hsa-miR-4282 catggAAATTTTtgtcttc
 0 UAAAAUUU m7b Created no TS 0.102000 -2.670000
hsa-miR-513a-3p catgGAAATTTttgtcttc
 2
 UAAAUUUC m7b Created -0.035000 -0.047000 -4.680000
hsa-miR-513c-3p catgGAAATTTttgtcttc
 2
 UAAAUUUC m7b Created -0.035000 -0.047000 -6.150000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.31524962C>A COSN8559314 tumor_4135099 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3942-3p ttggaggATCTGAAcatac
 0 UUUCAGAU m7b Disrupted -0.017000 no TS 1.010000
hsa-miR-5007-3p ttggaggATATGAacatac
 2
 AUCAUAUG m6b Created 0.048000 0.036000 -0.510000
hsa-miR-5100 ttggagGATCTGAAcatac
 0 UUCAGAUC m8a Disrupted -0.211000 no TS 0.610000


Mutation Mutation ID Sample Name Cancer Type
chr2:g.31525024A>C COSN8768590 SS6003314 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr2:g.31525492G>A COSN6178507 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3176 ttcttgaAGGCCAGgtttt
 2
 ACUGGCCU m7b Disrupted -0.197000 no TS 4.910000
hsa-miR-3663-5p ttcttgaAGACCAGgtttt
 0 GCUGGUCU m7b Created no TS -0.150000 No effect
hsa-miR-3922-3p ttcttgaAGGCCAGgtttt
 2
 UCUGGCCU m7b Disrupted -0.197000 no TS 0.030000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.31525732C>T COSN1835913 RK073_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-193a-5p ccacaAAGACCCAgagcaa
 1
 UGGGUCUU m8a Disrupted -0.307000 no TS 2.650000
hsa-miR-326 ccacaaagaCCCAGAGcaa
 4
 CCUCUGGG m7b (m7b->m6b) -0.175000 no TS 0.850000
hsa-miR-330-5p ccacaaagaCCCAGAGcaa
 4
 UCUCUGGG m7b (m7b->m6b) -0.194000 no TS 0.920000
hsa-miR-4782-5p ccacaaagATCCAGAgcaa
 4
 UUCUGGAU m7b Created -0.078000 -0.146000 -0.940000
hsa-miR-518c-5p ccacaaagaTCCAGAGcaa
 0 UCUCUGGA m7b (m6b->m7b) no TS -0.143000 -0.050000
hsa-miR-5706 ccacaaagATCCAGAgcaa
 4
 UUCUGGAU m7b Created -0.071000 -0.167000 -2.090000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.31525931G>C COSN9370411 AOCS-116-1-3 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2278 tatTGCTCTCagaaagtac
 0 GAGAGCAG m7a (m6b->m7a) NA NA -0.710000
hsa-miR-4251 tattgcTCTCAGaaagtac
 3
 CCUGAGAA m6b Created -0.106000 -0.204000 -0.020000
hsa-miR-4303 tattgctCTCAGAAagtac
 2
 UUCUGAGC m7a Created -0.200000 -0.288000 -0.030000
hsa-miR-4329 tattgcTCTCAGaaagtac
 0 CCUGAGAC m6b Created no TS -0.107000 No effect
hsa-miR-4330 tattgcTCTGAGaaagtac
 2
 CCUCAGAU m6b Disrupted -0.113000 no TS 0.030000
hsa-miR-4762-3p tattgctcTCAGAAagtac
 0 CUUCUGAU m6b Created no TS -0.044000 -0.170000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
31526012 rs187749379 G G hsa-miR-4292
hsa-miR-4308
hsa-miR-615-5p
hsa-miR-6791-5p
4
2
2
4
 ttCCAGGGAcccc
tTCCAGGGAcccc
ttccagGGACCCC
ttCCAGGGAcccc
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.123
-0.329
-0.255
-0.133
A hsa-miR-1299
hsa-miR-3191-5p
hsa-miR-326
hsa-miR-330-5p
hsa-miR-518c-5p
hsa-miR-593-3p
hsa-miR-6128
hsa-miR-6764-3p
hsa-miR-6824-3p
hsa-miR-875-3p
2
4
4
4
2
2
2
4
4
2
 TTCCAGAgacccc
ttCCAGAGAcccc
ttCCAGAGAcccc
ttCCAGAGAcccc
tTCCAGAGAcccc
ttcCAGAGACccc
TTCCAGAgacccc
ttCCAGAGAcccc
ttCCAGAGAcccc
TTCCAGAgacccc
 Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
N
N
 -0.058
-0.138
-0.08
-0.087
-0.287
-0.134
-0.061
-0.092
-0.089
-0.055

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