| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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| RefSeq ID: | NM_018327 |
|---|---|
| Gene Symbol: | SPTLC3 |
| Description: | Homo sapiens serine palmitoyltransferase, long chain base subunit 3 (SPTLC3), mRNA. |
| Gene Location: | chr20(+):12989626-13147411 |
| Browse Associations | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr20:g.13165507T>C | COSN9395679 | AOCS-084-1-X | [ovary][NS][other][neoplasm] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-3125 |
ttttccttTTCCTCTtgct |
0 | UAGAGGAA | m7b | Disrupted | -0.100000 | no TS | No effect | |
| hsa-miR-3153 |
ttttcCTTTCCCtcttgct |
2 |
GGGGAAAG | m7b | Created | -0.080000 | -0.141000 |
-0.010000 |
|
| hsa-miR-3916 |
ttttccttTTCCTCTTgct |
0 | AAGAGGAA | m8a | Disrupted | -0.081000 | no TS | No effect | |
| hsa-miR-5584-5p |
ttttccTTTCCCTcttgct |
0 | CAGGGAAA | m7b | Created | no TS | -0.054000 | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr20:g.13165527A>G | COSN14599332 | 8049223 | [pancreas][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1183 |
gtctcCTACAGTtttacag |
8 |
CACUGUAG | m7b | Disrupted | -0.082000 | no TS |
0.760000 |
|
| hsa-miR-1537 |
gtctcctACGGTTTTacag |
0 | AAAACCGU | m8a | Created | no TS | -0.164000 |
-0.180000 |
|
| hsa-miR-548a-3p |
gtctcctaCAGTTTTacag |
0 | CAAAACUG | m7b | Disrupted | -0.001000 | no TS | No effect | |
| hsa-miR-548aa |
gtctcctacGGTTTTacag |
4 |
AAAAACCA | m6b | Created | 0.001000 | 0.042000 | No effect | |
| hsa-miR-548ap-3p |
gtctcctacGGTTTTacag |
4 |
AAAAACCA | m6b | Created | 0.001000 | 0.042000 |
-0.010000 |
|
| hsa-miR-548ar-3p |
gtctcctaCAGTTTTAcag |
0 | UAAAACUG | m8a | Disrupted | 0.020000 | no TS | No effect | |
| hsa-miR-548at-3p |
gtctcctaCGGTTTTacag |
0 | CAAAACCG | m7b | Created | no TS | -0.119000 | No effect | |
| hsa-miR-548av-3p |
gtctcctaCAGTTTTacag |
0 | AAAACUGC | m7a | Disrupted | -0.136000 | -0.136000 | No effect | |
| hsa-miR-548e |
gtctcctaCAGTTTTacag |
0 | AAAAACUG | m7b | Disrupted | -0.001000 | no TS |
0.080000 |
|
| hsa-miR-548f |
gtctcctaCAGTTTTacag |
0 | AAAAACUG | m7b | Disrupted | -0.001000 | no TS | No effect | |
| hsa-miR-548g-3p |
gtctcctACAGTTTTacag |
8 |
AAAACUGU | m8a | Disrupted | -0.032000 | no TS |
0.260000 |
|
| hsa-miR-548t-3p |
gtctcctacGGTTTTacag |
4 |
AAAAACCA | m6b | Created | 0.001000 | 0.042000 | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr20:g.13165839T>C | COSN5763051 | HX20T | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-3185 |
ttctgaCTTCTTCaagacc |
0 | AGAAGAAG | m7b | Created | -0.187000 | -0.243000 |
-1.220000 |
|
| hsa-miR-4635 |
ttctgacttCTTCAAGAcc |
14 |
UCUUGAAG | m8a | (m7b->m8a) | -0.117000 | -0.235000 |
-0.830000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr20:g.13166726C>T | COSN10011395 | C0083T | [kidney][NS][other][neoplasm] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-miR-3190-3p |
gtcCTTCCACAaggtatgg |
1 |
UGUGGAAG | m8a | Disrupted | -0.362000 | no TS |
1.540000 |
| hsa-miR-3200-3p |
gtccttccaCAAGGTatgg |
5 |
CACCUUGC | m6b | Disrupted | -0.145000 | no TS |
4.230000 |
| hsa-miR-3688-3p |
gtccTTCCATAaggtatgg |
0 | UAUGGAAA | m7a | Created | no TS | -0.072000 |
-3.090000 |
| Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
|---|---|---|---|---|---|---|---|---|---|
| 13165154 | rs183283922 | T | T |
hsa-miR-4438 hsa-miR-6768-5p |
5 5 |
AGCCTGTgtttta agCCTGTGTttta |
Disrupted Disrupted |
N N |
-0.214 -0.183 |
| G |
hsa-miR-548aa hsa-miR-548ap-3p hsa-miR-548as-3p hsa-miR-548at-3p hsa-miR-548ay-3p hsa-miR-548t-3p |
15 15 7 15 15 15 |
agcctgGGTTTTA agcctgGGTTTTA agcctGGGTTTTA agcctgGGTTTTA agcctgGGTTTTA agcctgGGTTTTA |
Created Created Created Created Created Created |
N N N N N N |
0.006 0.006 -0.226 -0.027 -0.03 0.006 |
|||
| 13166725 | rs1045351 | A | A |
hsa-miR-3190-3p hsa-miR-3202 hsa-miR-4533 hsa-miR-4752 hsa-miR-6833-5p |
1 1 1 1 1 |
cCTTCCACAaggt CCTTCCAcaaggt CCTTCCAcaaggt cctTCCACAAggt ccTTCCACAAggt |
Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N |
-0.362 -0.128 -0.18 -0.138 -0.292 |
| C |
hsa-miR-2110 hsa-miR-3150a-3p hsa-miR-3189-3p hsa-miR-4271 hsa-miR-450a-2-3p hsa-miR-4725-3p hsa-miR-4747-5p hsa-miR-5196-5p hsa-miR-6763-5p hsa-miR-6780b-5p hsa-miR-6810-5p hsa-miR-6813-3p hsa-miR-6857-5p |
1 1 3 1 1 1 1 1 1 1 1 3 1 |
ccTTCCCCAAggt cctTCCCCAAggt ccttcCCCAAGGt cCTTCCCCAaggt cctTCCCCAAggt cCTTCCCCAaggt CCTTCCCcaaggt CCTTCCCcaaggt cctTCCCCAAggt cCTTCCCCAaggt cctTCCCCAAggt ccttccCCAAGGT cctTCCCCAAggt |
Created Created Created Created Created Created Created Created Created Created Created Created Created |
N N N N N N N N N N N N N |
-0.313 -0.149 -0.238 -0.385 -0.191 -0.395 -0.225 -0.234 -0.146 -0.374 -0.163 -0.253 -0.168 |