SomamiR DB

SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only All 6mer or longer seed matches

PolymiRTS Database

RefSeq ID:	NM_001127496
Gene Symbol:	SPRY4
Description:	Homo sapiens sprouty homolog 4 (Drosophila) (SPRY4), transcript variant 2, mRNA.
Gene Location:	chr5(-):141689991-141704620
Browse Associations
Browse Pathways

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.142310516T>C			COSN2073655		RK004_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4719	tcttctgTTTGTGAagaaa	21	UCACAAAU	m7a	Disrupted	-0.071000	no TS	No effect
hsa-miR-4719	tcttctgTTTGTGAagaaa	0	UCACAAAU	m7a	Disrupted	-0.071	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.142310830T>C			COSN7877952		8069321		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-106a-5p	tgacaaGCACTTTTgtgcc	15	AAAAGUGC	m8a	Created	-0.016000	-0.097000	-0.360000
hsa-miR-106b-5p	tgacaaGCACTTTtgtgcc	15	UAAAGUGC	m7b	Created	-0.016000	-0.097000	-0.140000
hsa-miR-17-5p	tgacaaGCACTTTtgtgcc	15	CAAAGUGC	m7b	Created	-0.016000	-0.097000	-0.360000
hsa-miR-20a-5p	tgacaaGCACTTTtgtgcc	15	UAAAGUGC	m7b	Created	-0.007000	-0.088000	-0.600000
hsa-miR-20b-5p	tgacaaGCACTTTtgtgcc	15	CAAAGUGC	m7b	Created	-0.007000	-0.088000	-0.520000
hsa-miR-302a-3p	tgacaAGCACTTttgtgcc	8	UAAGUGCU	m7b	Created	-0.130000	-0.239000	-0.050000
hsa-miR-302b-3p	tgacaAGCACTTttgtgcc	8	UAAGUGCU	m7b	Created	-0.130000	-0.239000	-0.330000
hsa-miR-302c-3p	tgacaAGCACTTttgtgcc	8	UAAGUGCU	m7b	Created	-0.130000	-0.239000	-0.200000
hsa-miR-302d-3p	tgacaAGCACTTttgtgcc	8	UAAGUGCU	m7b	Created	-0.130000	-0.239000	-0.020000
hsa-miR-302e	tgacaAGCACTTttgtgcc	8	UAAGUGCU	m7b	Created	-0.130000	-0.230000	-0.030000
hsa-miR-372	tgacaAGCACTTTtgtgcc	8	AAAGUGCU	m8a	Created	-0.149000	-0.258000	No effect
hsa-miR-373-3p	tgacaAGCACTTttgtgcc	8	GAAGUGCU	m7b	Created	-0.130000	-0.221000	No effect
hsa-miR-519d	tgacaaGCACTTTtgtgcc	15	CAAAGUGC	m7b	Created	-0.053000	-0.116000	No effect
hsa-miR-520a-3p	tgacaAGCACTTTtgtgcc	8	AAAGUGCU	m8a	Created	-0.140000	-0.240000	-0.010000
hsa-miR-520b	tgacaAGCACTTTtgtgcc	8	AAAGUGCU	m8a	Created	-0.130000	-0.230000	-0.070000
hsa-miR-520c-3p	tgacaAGCACTTTtgtgcc	8	AAAGUGCU	m8a	Created	-0.130000	-0.230000	-0.030000
hsa-miR-520d-3p	tgacaAGCACTTTtgtgcc	8	AAAGUGCU	m8a	Created	-0.149000	-0.249000	-0.040000
hsa-miR-520e	tgacaAGCACTTTtgtgcc	8	AAAGUGCU	m8a	Created	-0.130000	-0.221000	No effect
hsa-miR-520f	tgacAAGCACTTttgtgcc	9	AAGUGCUU	m8a	Created	-0.131000	-0.239000	-0.430000
hsa-miR-526b-3p	tgacaaGCACTTTtgtgcc	15	GAAAGUGC	m7b	Created	-0.035000	-0.107000	-0.370000
hsa-miR-548t-5p	tgacaagCACTTTTGtgcc	0	CAAAAGUG	m8a	Created	no TS	0.041000	No effect
hsa-miR-636	tgaCAAGCACttttgtgcc	0	UGUGCUUG	m7b	(m6c->m7b)	no TS	-0.154000	-0.020000
hsa-miR-93-5p	tgacaaGCACTTTtgtgcc	15	CAAAGUGC	m7b	Created	-0.025000	-0.106000	-0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.142310980G>A			COSN6583901		ICGC_MB110		[central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3126-3p	ccagaacCCAGATGactgt	0	CAUCUGGC	m7a	Created	NA	NA	0.540000
hsa-miR-4507	ccagAACCCAGatgactgt	0	CUGGGUUG	m7a	Created	NA	NA	No effect
hsa-miR-452-3p	ccagaaccCAGATGActgt	0	CUCAUCUG	m7b	Created	0.087000	0.074000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.142311254C>T			COSN14963469		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-298	cagcgCTTCTGCgagcacc	1	AGCAGAAG	m7b	Created	-0.023000	0.022000	-0.110000

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.142311677A>G			COSN6865645		RK128_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4655-3p	aaggagCGAGGGaaccatc	0	ACCCUCGU	m6b	Created	no TS	-0.129000	-0.090000
hsa-miR-642a-5p	aaggagcGAGGGAaccatc	0	GUCCCUCU	m6b	Created	no TS	0.003000	-0.010000
hsa-miR-642b-5p	aaggagcgAGGGAACCatc	0	GGUUCCCU	m8a	Created	no TS	0.030000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.142311935C>A			0_231				Prostate cancer
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3650	cacacACACACCTacccca	5	AGGUGUGU	m8a	Created	0.121	0.091	-0.6
hsa-miR-4455	cacaCACACCCctacccca	5	AGGGUGUG	m7b	Disrupted	-0.062	-0.018	0.67

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.142311962T>C			COSN6510501		HX30T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-147a	agctgtgtaCACACACaca	0	GUGUGUGG	m7a	(m6a->m7a)	NA	NA	-0.180000
hsa-miR-223-5p	agctgtgtATACACacaca	0	CGUGUAUU	m6b	Disrupted	0.087000	no TS	No effect
hsa-miR-3177-5p	agctgTGTACACAcacaca	0	UGUGUACA	m8a	Created	no TS	0.063000	-0.040000
hsa-miR-466	agcTGTGTATacacacaca	2	AUACACAU	m7a	(m7a->m6b)	0.135000	0.135000	No effect
hsa-miR-4789-5p	agctGTGTATACacacaca	0	GUAUACAC	m8a	Disrupted	0.033000	-0.018000	0.210000

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.142312094C>T			COSN9408793		AOCS-111-1-X		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4251	tctgcgaggTCTCAGaact	0	CCUGAGAA	m6b	Created	-0.028000	0.055000	-0.020000
hsa-miR-4329	tctgcgagGTCTCAGaact	0	CCUGAGAC	m7b	Created	no TS	0.086000	-0.010000
hsa-miR-4649-3p	tctgcgagGCCTCAGAact	0	UCUGAGGC	m8a	Disrupted	0.035000	0.006000	-0.760000
hsa-miR-769-5p	tctgcgAGGTCTCAgaact	0	UGAGACCU	m8a	Created	no TS	0.064000	-0.150000

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.142313089T>C			COSN6865648		RK210_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.142313319G>A			COSN195736		PD4199a		[NS][NS][NS][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-151a-3p	aatgAGTCTAaggctgtgg	0	CUAGACUG	m6b	Created	no TS	-0.020000	-1.810000
hsa-miR-4494	aatgAGTCTGaggctgtgg	16	CCAGACUG	m6b	Disrupted	-0.025000	no TS	0.420000
hsa-miR-499b-5p	aatgAGTCTGaggctgtgg	16	ACAGACUU	m6b	Disrupted	-0.028000	no TS	10.830000
hsa-miR-151a-3p	aatgAGTCTAaggctgtgg	0	CUAGACUG	m6b	Created	no TS	-0.02	-1.81
hsa-miR-4494	aatgAGTCTGaggctgtgg	0	CCAGACUG	m6b	Disrupted	-0.025	no TS	0.42
hsa-miR-499b-5p	aatgAGTCTGaggctgtgg	0	ACAGACUU	m6b	Disrupted	-0.028	no TS	10.83

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.142313511C>A			COSN5069985		HX19T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3202	ttctCCCTTCCAactgcat	0	UGGAAGGG	m8a	Disrupted	-0.725000	-0.468000	4.760000
hsa-miR-4533	ttctcCCTTCCAactgcat	0	UGGAAGGA	m7a	Disrupted	-0.072000	-0.014000	0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.142313836G>T			COSN6510502		HX33T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-25-5p	cctccCTCCGCCccccccc	0	AGGCGGAG	m7b	Disrupted	-0.157000	no TS	0.160000
hsa-miR-3180	cctccctCCGCCCCccccc	0	UGGGGCGG	m7b	Disrupted	-0.423000	-0.200000	3.900000
hsa-miR-3180-3p	cctccctCCGCCCCccccc	0	UGGGGCGG	m7b	Disrupted	-0.432000	-0.200000	3.650000
hsa-miR-3196	cctccctCCGCCCCccccc	0	CGGGGCGG	m7b	Disrupted	-0.423000	-0.200000	2.830000
hsa-miR-4488	cctccctcCGCCCCCcccc	0	AGGGGGCG	m7b	Disrupted	-0.154000	no TS	3.210000
hsa-miR-4697-5p	cctccctcCGCCCCCcccc	0	AGGGGGCG	m7b	Disrupted	-0.136000	no TS	0.170000
hsa-miR-4723-5p	cctccctcCTCCCCCcccc	0	UGGGGGAG	m7b	Created	no TS	-0.127000	-0.100000
hsa-miR-4779	cctCCCTCCTccccccccc	4	UAGGAGGG	m7b	(m6c->m7b)	-0.089000	-0.169000	-0.370000
hsa-miR-5698	cctccctcCTCCCCCcccc	0	UGGGGGAG	m7b	Created	no TS	-0.108000	-0.010000
hsa-miR-658	cctcCCTCCGCCccccccc	0	GGCGGAGG	m8a	Disrupted	-0.166000	no TS	3.060000
hsa-miR-765	cctccCTCCTCCccccccc	0	UGGAGGAG	m7b	Created	no TS	-0.055000	-0.850000

**Germline mutations in target sites of miRNAs in somatic mutation table**
Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
142310980	rs190918583	G
142310980	rs190918583	G	A	hsa-miR-1298-3p hsa-miR-23a-5p hsa-miR-23b-5p hsa-miR-452-3p hsa-miR-6776-5p hsa-miR-6861-5p	2 1 1 2 2 2	gaaCCCAGATgac GAACCCAgatgac GAACCCAgatgac gaaccCAGATGAc gaACCCAGAtgac gaACCCAGAtgac	Created Created Created Created Created Created	N N N N N N	-0.156 -0.097 -0.093 -0.013 -0.083 -0.098
142311254	rs3797053	T
142311254	rs3797053	T	T	hsa-miR-298 hsa-miR-6767-5p	1 1	cgCTTCTGCgagc cgctTCTGCGAgc	Disrupted Disrupted	N N	0.045 -0.092
142311469	rs200238872	-	AT	hsa-miR-4643 hsa-miR-466 hsa-miR-4789-3p	2 2 2	acacaCATGTGTAgc acacacATGTGTAgc acacacATGTGTAgc	Unknown Unknown Unknown	N N N	0.023 0.135 0.052
142311469	rs200238872	-	-
142311470	rs73796079	A	A	hsa-miR-4643 hsa-miR-466 hsa-miR-4789-3p hsa-miR-6867-5p	2 2 2 2	acacaCATGTGTA acacacATGTGTA acacacATGTGTA ACACACAtgtgta	Disrupted Disrupted Disrupted Disrupted	N N N N	0.023 0.135 0.052 0.03
142311470	rs73796079	A	G	hsa-miR-329-3p hsa-miR-362-3p hsa-miR-3941 hsa-miR-603	2 2 2 2	acacacGTGTGTA acacacGTGTGTA acacacGTGTGTA acacacGTGTGTA	Created Created Created Created	N N N N	0.019 0.026 0.071 0.025
142311935	rs141819080	-	-	hsa-miR-3650 hsa-miR-4455 hsa-miR-6747-5p hsa-miR-6782-5p	2 2 2 2	cacacacacACACACCcctaccccacactga cacacacacaCACACCCctaccccacactga cacacacacacACACCCCtaccccacactga cacacacacacaCACCCCTAccccacactga	Unknown Unknown Unknown Unknown	N N N N	-0.003 -0.003 -0.003 -0.004
142311935	rs141819080	-	ACACACACAC	hsa-miR-6867-5p	2	cacacacaCACACACAcacacacacccctaccccacactga	Unknown	N	0.466
142311936	rs72117814	-	-	hsa-miR-3650 hsa-miR-4455 hsa-miR-6747-5p hsa-miR-6782-5p hsa-miR-6867-5p	2 2 2 2 3	acacacacacacacACACACCcctaccccacactgactg acacacacacacacaCACACCCctaccccacactgactg acacacacacacacacACACCCCtaccccacactgactg acacacacacacacacaCACCCCTAccccacactgactg acacacacacacaCACACACccctaccccacactgactg	Unknown Unknown Unknown Unknown Unknown	N N N N N	-0.012 -0.016 -0.015 -0.066 -0.302
142311936	rs72117814	-	ACACACACACACAC	hsa-miR-147a hsa-miR-6818-5p	3 3	acacacacacacaCACACAAcacacacacacaccccctaccccacactgactg acacacacacacaCACACAAcacacacacacaccccctaccccacactgactg	Unknown Unknown	N N	0.072 0.074
142311939	rs72396429	-	-	hsa-miR-4455 hsa-miR-6747-5p hsa-miR-6867-5p	7 10 5	cacacacacaCACACCCctaccc cacacacacacACACCCCtaccc cacaCACACACAcacccctaccc	Unknown Unknown Unknown	N N N	-0.044 0.061 0.257
142311939	rs72396429	-	CACACA	hsa-miR-147a hsa-miR-3650 hsa-miR-3911 hsa-miR-644a hsa-miR-6818-5p	5 5 7 7 10	cacacacacaCCACACAAcacccctaccc cacacACACACCAcacaacacccctaccc cacacacacaCCACACAacacccctaccc cacacacacaCCACACAacacccctaccc cacacacacacCACACAAcacccctaccc	Unknown Unknown Unknown Unknown Unknown	N N N N N	0.031 -0.033 0.028 0.038 0.072
142311941	rs71732823	-	-	hsa-miR-6867-5p	5	cacacacaCACACACAcacacccctacccca	Unknown	N	0.164
142311941	rs71732823	-	CACACACACA	hsa-miR-147a hsa-miR-3650 hsa-miR-3911 hsa-miR-644a	3 6 7 7	cacacacacacacaCCACACAcacaacacacccctacccca cacacacacACACACCAcacacacaacacacccctacccca cacacacacacacaCCACACAcacaacacacccctacccca cacacacacacacaCCACACAcacaacacacccctacccca	Unknown Unknown Unknown Unknown	N N N N	0.105 0.001 0.029 0.039
142312703	rs34629388	-	-	hsa-miR-1343-5p hsa-miR-3150a-3p hsa-miR-3175 hsa-miR-320a hsa-miR-320b hsa-miR-320c hsa-miR-320d hsa-miR-320e hsa-miR-4429 hsa-miR-4667-5p hsa-miR-4700-5p hsa-miR-4731-5p hsa-miR-6763-5p hsa-miR-6825-5p hsa-miR-8089 hsa-miR-939-5p	8 8 8 8 8 8 8 8 8 13 13 14 8 7 13 8	cCTCCCCAgcttt cCTCCCCAgcttt cCTCCCCAgcttt cctcccCAGCTTT cctcccCAGCTTT cctcccCAGCTTT cctcccCAGCTTT cctccCCAGCTTt cctcccCAGCTTT ccTCCCCAGcttt ccTCCCCAGcttt cctCCCCAGCttt cCTCCCCAgcttt CCTCCCCAgcttt ccTCCCCAGcttt cCTCCCCAgcttt	Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown	N N N N N N N N N N N N N N N N	-0.02 0.017 -0.022 -0.009 -0.009 -0.009 -0.009 -0.011 -0.009 -0.042 -0.024 -0.034 0.017 -0.047 -0.005 -0.02
142312703	rs34629388	-	C	hsa-miR-1275 hsa-miR-4525 hsa-miR-4665-5p hsa-miR-4723-5p hsa-miR-5010-5p hsa-miR-5698 hsa-miR-625-5p hsa-miR-637 hsa-miR-6870-5p hsa-miR-7111-5p	13 13 13 8 13 8 13 14 8 8	ccTCCCCCAgcttt ccTCCCCCAgcttt ccTCCCCCAgcttt cCTCCCCCAgcttt ccTCCCCCAgcttt cCTCCCCCAgcttt ccTCCCCCAgcttt cctCCCCCAGcttt cCTCCCCCAgcttt cCTCCCCCAgcttt	Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown	N N N N N N N N N N	0.021 -0.029 0.012 -0.116 -0.039 -0.084 -0.026 -0.059 -0.084 -0.147
142313466	rs184161862	G
142313466	rs184161862	G	A	hsa-miR-1193 hsa-miR-2392 hsa-miR-3650	14 14 4	cacACCATCCttc cacaCCATCCTtc CACACCAtccttc	Created Created Created	N N N	-0.106 -0.131 -0.08
142313824	rs201449499	T	T	hsa-miR-3125 hsa-miR-3179 hsa-miR-3202 hsa-miR-3916 hsa-miR-4476 hsa-miR-6859-5p hsa-miR-6876-5p	13 0 6 13 9 13 9	ccccccTTCCTCT ccCCCCTTCctct cccCCCTTCCtct ccccccTTCCTCT ccccCCTTCCTct ccccccTTCCTCT ccccCCTTCCTct	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N	-0.021 -0.037 -0.073 -0.021 -0.051 -0.031 -0.051
142313824	rs201449499	T	C	hsa-miR-4779	9	ccccCCCTCCTct	Created	N	-0.068
142313825	rs57741967	-	CCC	hsa-miR-3179 hsa-miR-3202 hsa-miR-4476 hsa-miR-6876-5p	0	cccccCCCCTTCctctt ccccccCCCTTCCtctt cccccccCCTTCCTctt cccccccCCTTCCTctt	Unknown Unknown Unknown Unknown	N N N N	0.005 0.016 0.005 0.005
142313825	rs57741967	-	-	hsa-miR-3125 hsa-miR-3916 hsa-miR-6859-5p	0	ccccccTTCCTCTt ccccccTTCCTCTt ccccccTTCCTCTt	Unknown Unknown Unknown	N N N	-0.015 -0.024 -0.023
142313833	rs60006206	C	C	hsa-miR-1237-5p hsa-miR-3180 hsa-miR-3180-3p hsa-miR-3196 hsa-miR-328-5p hsa-miR-4488 hsa-miR-4697-5p hsa-miR-6816-5p hsa-miR-6885-5p	0	tcCGCCCCCcccc tCCGCCCCccccc tCCGCCCCccccc tCCGCCCCccccc tccGCCCCCCccc tcCGCCCCCcccc tcCGCCCCCcccc tCCGCCCCccccc tccGCCCCCCccc	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N	-0.003 -0.036 -0.036 -0.036 0.013 -0.003 -0.003 -0.036 0.041
142313833	rs60006206	C	G	hsa-miR-3960 hsa-miR-4467 hsa-miR-8072	0	tCCGCCGCccccc tcCGCCGCCcccc tCCGCCGCccccc	Created Created Created	N N N	-0.283 -0.193 -0.274

**Genome Browser**
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Somatic mutations that impact miRNA target sites

Germline mutations in target sites of miRNAs in somatic mutation table

Genome Browser