SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_000346
Gene Symbol: SOX9
Description: Homo sapiens SRY (sex determining region Y)-box 9 (SOX9), mRNA.
Gene Location: chr17(+):70117160-70122560
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr17:g.72124410A>C COSN15315942 SNUH_G76_S1 [haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1181 gaagGGCGACGatggccga
 0 CCGUCGCC m7b Created no TS -0.664000 -9.450000
hsa-miR-1181 gaagGGCGACGatggccga
 0 CCGUCGCC m7b Created no TS -0.664000 -9.450000
hsa-miR-1181 gaagGGCGACGatggccga
 0 CCGUCGCC m7b Created no TS -0.664 -9.45

Mutation Mutation ID Sample Name Cancer Type
chr17:g.72124514C>T COSN5842299 HCC154 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3185 ttgttttttCTTCTTCTtc
 3
 AGAAGAAG m8a (m8a->m7b) -0.668000 -0.513000 No effect
hsa-miR-3185 ttgttttttCTTCTTCTtc
 3
 AGAAGAAG m8a (m8a->m7b) -0.668000 -0.513000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr17:g.72124532T>C COSN6111259 RK187_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1224-5p cttctTCCTCAaagacatt
 12
 GUGAGGAC m6b Created -0.056000 -0.206000 -3.000000
hsa-miR-302b-5p cttcttccTTAAAGacatt
 9
 ACUUUAAC m6b Disrupted 0.044000 0.051000 0.690000
hsa-miR-302d-5p cttcttccTTAAAGacatt
 9
 ACUUUAAC m6b Disrupted 0.055000 0.052000 0.160000
hsa-miR-3915 cttcTTCCTCAAagacatt
 0 UUGAGGAA m8a Created -0.298000 -0.611000 -1.800000
hsa-miR-3928 cttcTTCCTCaaagacatt
 0 GGAGGAAC m6b Created -0.126000 -0.269000 -0.090000
hsa-miR-4477b cttctTCCTTAAagacatt
 7
 AUUAAGGA m7b Disrupted -0.251000 0.005000 0.050000
hsa-miR-4689 cttctTCCTCAAagacatt
 12
 UUGAGGAG m7a Created -0.049000 -0.185000 -0.690000

Mutation Mutation ID Sample Name Cancer Type
chr17:g.72125133A>G COSN6111260 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-205-5p aaaaaaaATGAAGGcctta
 0 UCCUUCAU m7b Created no TS -0.099000 -5.790000
hsa-miR-5696 aaaaaAAATGAaggcctta
 3
 CUCAUUUA m6b Created -0.001000 0.082000 -0.310000

Mutation Mutation ID Sample Name Cancer Type
chr17:g.72125910G>T ICGC_8CD1F3AE-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-329 gtgtgtgtgGGTGTGTgtg
 0 AACACACC m7b (m7b->m6c) -0.111 no TS 1.55
hsa-miR-362-3p gtgtgtgtgGGTGTGTgtg
 0 AACACACC m7b (m7b->m6c) -0.111 no TS 2.04

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
72124410 rs1042667 A A hsa-miR-6726-3p
2
 GGGCGAAgatggc
 Disrupted
N
 -0.282
C hsa-miR-1181
2
 gGGCGACGAtggc
 Created
N
 -0.664

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