SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_006932
Gene Symbol:	SMTN
Description:	Homo sapiens smoothelin (SMTN), transcript variant 4, mRNA.
Gene Location:	chr22(+):31477281-31500610
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr22:g.31104477C>T			COSN5770777		CCC64		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3937	ctgcCCGCCTGcatggcca	0	ACAGGCGG	m7b	Created	no TS	0.000000	-0.170000
hsa-miR-4767	ctgccCGCCCGCatggcca	0	CGCGGGCG	m7b	Disrupted	0.000000	no TS	-1.070000
hsa-miR-3937	ctgcCCGCCTGcatggcca	0	ACAGGCGG	m7b	Created	no TS	0.000000	-0.170000
hsa-miR-4767	ctgccCGCCCGCatggcca	0	CGCGGGCG	m7b	Disrupted	0.000000	no TS	-1.070000

Mutation			Mutation ID		Sample Name		Cancer Type
chr22:g.31104550G>A			COSN6692630		CHC433T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-34a-5p	ccgcccacCACTGCCctgt	0	UGGCAGUG	m7b	Created	no TS	-0.132000	-1.520000
hsa-miR-34c-5p	ccgcccacCACTGCCctgt	0	AGGCAGUG	m7b	Created	no TS	-0.132000	-3.640000
hsa-miR-449a	ccgcccacCACTGCCctgt	0	UGGCAGUG	m7b	Created	no TS	-0.123000	-2.240000
hsa-miR-449b-5p	ccgcccacCACTGCCctgt	0	AGGCAGUG	m7b	Created	no TS	-0.123000	-2.380000
hsa-miR-541-3p	ccGCCCACCActgccctgt	8	UGGUGGGC	m8a	(m7a->m8a)	-0.132000	-0.357000	-3.350000
hsa-miR-654-5p	ccGCCCACCActgccctgt	8	UGGUGGGC	m8a	(m7a->m8a)	-0.151000	-0.378000	-3.340000
hsa-miR-885-3p	ccgcccacCGCTGCCctgt	6	AGGCAGCG	m7b	Disrupted	-0.174000	no TS	1.980000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
31104473	rs201517028	C	C	hsa-miR-4767 hsa-miR-6721-5p hsa-miR-7112-5p	0	cctgccCGCCCGC CCTGCCCgcccgc cCTGCCCGcccgc	Disrupted Disrupted Disrupted	N N N	No Change No Change No Change
			T	hsa-miR-4514 hsa-miR-4692 hsa-miR-6808-5p hsa-miR-6893-5p hsa-miR-940	0	cCTGCCTGcccgc cCTGCCTGcccgc CCTGCCTgcccgc CCTGCCTgcccgc CCTGCCTgcccgc	Created Created Created Created Created	N N N N N	No Change No Change No Change No Change No Change
31104550	rs10304	G	G	hsa-miR-6786-5p hsa-miR-885-3p	7 6	CCCACCGctgccc cccacCGCTGCCc	Disrupted Disrupted	N N	-0.215 -0.174
			A	hsa-miR-34a-5p hsa-miR-34c-5p hsa-miR-449a hsa-miR-449b-5p hsa-miR-541-3p hsa-miR-654-5p hsa-miR-6769a-5p hsa-miR-6769b-5p hsa-miR-92a-2-5p	6 6 6 6 7 7 7 7 7	cccacCACTGCCc cccacCACTGCCc cccacCACTGCCc cccacCACTGCCc CCCACCActgccc CCCACCActgccc CCCACCActgccc CCCACCActgccc CCCACCActgccc	Created Created Created Created Created Created Created Created Created	N N N N N N N N N	-0.132 -0.132 -0.123 -0.123 -0.225 -0.227 -0.128 -0.128 -0.106

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