SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001207018
Gene Symbol:	SMTN
Description:	Homo sapiens smoothelin (SMTN), transcript variant 4, mRNA.
Gene Location:	chr22(+):31480981-31500610
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr22:g.31104348A>A			ICGC_45349		TCGA-CF-A3MF-01A-12D-A21A-08		BladderUrothelialCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1306-5p	tggtGGAGGTGGacgacat	0	CCACCUCC	m8a	Disrupted	-0.192	no TS	8.08
hsa-miR-5193	tggtgGAGGAGGAcgacat	0	UCCUCCUC	m8a	Created	no TS	-0.329	-10.8

Mutation			Mutation ID		Sample Name		Cancer Type
chr22:g.31104444G>A			ICGC_1451298		TCGA-A5-A0VP-01A-21D-A10B-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-143-5p	acgaACTGCACCtgcgcgg	0	GGUGCAGU	m8a	Created	no TS	-0.112	-4.78
hsa-miR-3665	acgaactgCACCTGCgcgg	0	AGCAGGUG	m7b	Created	-0.151	-0.29	-2.6
hsa-miR-764	acgaactGCACCTGCgcgg	0	GCAGGUGC	m8a	Created	no TS	-0.147	-3.9

Mutation			Mutation ID		Sample Name		Cancer Type
chr22:g.31104457G>C			ICGC_1451299		TCGA-B5-A11R-01A-11D-A122-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4423-5p	gcgcGGCAACaatgtctag	0	AGUUGCCU	m6b	Created	no TS	-0.111	0.14
hsa-miR-744-3p	gcgcGGCAACAatgtctag	0	CUGUUGCC	m7b	Created	no TS	-0.23	-3.55

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
31104425	rs115440473	C	C	hsa-miR-3665 hsa-miR-876-3p	9 9	aacCACCTGCgac AACCACCtgcgac	Disrupted Disrupted	N N	-0.151 -0.126
			T	hsa-miR-140-5p	9	AACCACTtgcgac	Created	N	-0.082
31104429	rs144949047	G
			A	hsa-miR-3665 hsa-miR-6511b-5p hsa-miR-657 hsa-miR-6811-5p	8 13 8 13	ACCTGCAacgcca aCCTGCAAcgcca ACCTGCAacgcca aCCTGCAAcgcca	Created Created Created Created	N N N N	-0.198 -0.106 -0.135 -0.116

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