SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
	Home	Search	Help	Download

Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_022137
Gene Symbol:	SMOC1
Description:	Homo sapiens SPARC related modular calcium binding 1 (SMOC1), transcript variant 1, mRNA.
Gene Location:	chr14(+):70346113-70499083
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.70030331G>A			COSN7025247		8047807		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4728-3p	acctTCAGCATtgcccatg	0	CAUGCUGA	m7b	Created	no TS	-0.118000	-0.390000

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.70030495C>G			COSN8387149		tumor_4163639		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][diffuse_large_B_cell_lymphoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.70030972C>A			COSN8156495		PCSI_0083_Pa_P_526		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-147a	atgaatagCACACACaggt	0	GUGUGUGG	m7a	Created	-0.036000	no TS	No effect
hsa-miR-4265	atgaataGCCCACAcaggt	0	CUGUGGGC	m7b	Disrupted	-0.178000	no TS	0.240000
hsa-miR-4296	atgaataGCCCACAcaggt	0	AUGUGGGC	m7b	Disrupted	-0.168000	no TS	1.780000
hsa-miR-4322	atgaataGCCCACAcaggt	0	CUGUGGGC	m7b	Disrupted	-0.168000	no TS	0.520000
hsa-miR-4417	atgaatAGCCCACacaggt	0	GGUGGGCU	m7b	Disrupted	-0.311000	no TS	4.500000
hsa-miR-644a	atgaatagcCCACACaggt	0	AGUGUGGC	m6b	Disrupted	-0.055000	no TS	0.240000

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.70031103G>A			COSN8848924		AOCS-138-3-X		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3171	ttgcatTACATCactcgaa	0	AGAUGUAU	m6b	Created	no TS	-0.026000	-0.040000
hsa-miR-380-3p	ttgcATTACATcactcgaa	0	UAUGUAAU	m7b	Created	no TS	0.053000	-2.390000
hsa-miR-4765	ttgcattacATCACTCgaa	0	UGAGUGAU	m7b	(m6c->m7b)	no TS	-0.081000	-1.710000

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.70031156G>T			COSN5172170		PD4085a		[breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-454-5p	aacgcatGATAGGGgaggc	0	ACCCUAUC	m7b	Created	no TS	-0.130000	-0.060000
hsa-miR-96-3p	aacgCATGATaggggaggc	0	AAUCAUGU	m6b	Created	no TS	0.026000	-2.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.70031516T>C			COSN6257547		RK136_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3653	ccctcaagtCTTCTTAtgg	0	CUAAGAAG	m7b	(m6c->m7b)	no TS	0.018000	-4.050000
hsa-miR-5197-3p	ccctcaagTCTTCTTatgg	0	AAGAAGAG	m7a	Created	NA	NA	-1.820000
hsa-miR-5582-3p	ccctcAAGTTTTcttatgg	0	UAAAACUU	m7b	Disrupted	0.126000	-0.015000	-0.120000

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.70031666C>T			COSN8156496		PCSI_0164_Pa_P_526		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-5092	catcttcCGTGGATTctag	0	AAUCCACG	m8a	Created	no TS	-0.094000	-5.370000

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.70031776G>A			COSN15062860		LP6005500-DNA_B01		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-342-5p	gcccttaGCACCCCTtccc	0	AGGGGUGC	m8a	Created	no TS	-0.207000	-0.200000
hsa-miR-3936	gcccttagcACCCCTTccc	0	UAAGGGGU	m7b	(m6c->m7b)	no TS	-0.082000	-0.090000
hsa-miR-4639-5p	gccCTTAGCAccccttccc	2	UUGCUAAG	m7b	(m6b->m7b)	-0.063000	-0.030000	No effect
hsa-miR-4664-5p	gcccttaGCACCCCttccc	0	UGGGGUGC	m7b	Created	no TS	-0.216000	-0.200000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
70031874	rs147757192	G	G	hsa-miR-300 hsa-miR-381-3p	5 5	catCTTGTATtcc catCTTGTATtcc	Disrupted Disrupted	N N	-0.028 -0.028
			C	hsa-miR-5197-3p	3	caTCTTCTAttcc	Created	N	-0.002

Genome Browser