SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001190821
Gene Symbol: SMAD7
Description: Homo sapiens SMAD family member 7 (SMAD7), transcript variant 2, mRNA.
Gene Location: chr18(-):46446222-46477081
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr18:g.48919991A>C COSN1745264 RK037_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-376a-5p tgctttAATCTAaatgcaa
 0 GUAGAUUC m6b Created no TS -0.073000 -0.210000
hsa-miR-4729 tgctttaatATAAATGcaa
 19
 UCAUUUAU m7b (m7b->m6b) -0.081000 0.025000 0.060000
hsa-miR-4760-5p tgctttAATCTAAAtgcaa
 0 UUUAGAUU m8a Created no TS -0.246000 -3.500000
hsa-miR-656 tgcttTAATATaaatgcaa
 20
 AAUAUUAU m6b Disrupted -0.004000 no TS No effect
hsa-miR-376a-5p tgctttAATCTAaatgcaa
 0 GUAGAUUC m6b Created no TS -0.073 -0.21
hsa-miR-4729 tgctttaatATAAATGcaa
 0 UCAUUUAU m7b (m7b->m6b) -0.081 0.025 0.06
hsa-miR-4760-5p tgctttAATCTAAAtgcaa
 0 UUUAGAUU m8a Created no TS -0.246 -3.5
hsa-miR-656 tgcttTAATATaaatgcaa
 0 AAUAUUAU m6b Disrupted -0.004 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr18:g.48920372T>G COSN1206701 HX17T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4442 tttgGTCCGGCataaccca
 0 GCCGGACA m7a Created NA NA -5.670000
hsa-miR-4633-5p tttggtccGGCATAaccca
 0 AUAUGCCU m6b Created no TS -0.078000 -11.160000
hsa-miR-4757-3p tttggtcCGTCATaaccca
 0 CAUGACGU m6b Disrupted -0.141000 no TS 3.740000
hsa-miR-4442 tttgGTCCGGCataaccca
 0 GCCGGACA m7a Created NA NA -5.67
hsa-miR-4633-5p tttggtccGGCATAaccca
 0 AUAUGCCU m6b Created no TS -0.078 -11.16
hsa-miR-4757-3p tttggtcCGTCATaaccca
 0 CAUGACGU m6b Disrupted -0.141 no TS 3.74

Mutation Mutation ID Sample Name Cancer Type
chr18:g.48920435C>T COSN6416475 HX36T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4286 gccagcaAGTGGGGatgtc
 7
 ACCCCACU m7b Created -0.084000 -0.373000 -12.760000

Mutation Mutation ID Sample Name Cancer Type
chr18:g.48920548C>G COSN1206702 HCC42T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1266 ctctcCCCTGAGcctctcc
 12
 CCUCAGGG m7b Created -0.382000 -0.423000 0.130000
hsa-miR-1914-3p ctctCCCCTCagcctctcc
 0 GGAGGGGU m6b Disrupted -0.176000 -0.077000 7.960000
hsa-miR-24-3p ctctcccCTGAGCCtctcc
 0 UGGCUCAG m7b Created no TS -0.032000 -10.270000
hsa-miR-2467-5p ctctcccctGAGCCTCtcc
 0 UGAGGCUC m7b (m6b->m7b) no TS -0.081000 1.530000
hsa-miR-3929 ctctccccTCAGCCTCtcc
 5
 GAGGCUGA m8a Disrupted 0.005000 no TS 10.870000
hsa-miR-4419b ctctccccTCAGCCTCtcc
 5
 GAGGCUGA m8a Disrupted -0.004000 no TS 8.140000
hsa-miR-4478 ctctccccTCAGCCTCtcc
 5
 GAGGCUGA m8a Disrupted -0.013000 no TS 4.830000
hsa-miR-4518 ctctcCCCTGAGCctctcc
 12
 GCUCAGGG m8a Created -0.372000 -0.422000 -1.560000
hsa-miR-485-5p ctctcccctCAGCCTCTcc
 5
 AGAGGCUG m8a (m8a->m7a) -0.048000 no TS No effect
hsa-miR-1266 ctctcCCCTGAGcctctcc
 0 CCUCAGGG m7b Created -0.382 -0.423 0.13
hsa-miR-1914-3p ctctCCCCTCagcctctcc
 0 GGAGGGGU m6b Disrupted -0.176 -0.077 7.96
hsa-miR-24-3p ctctcccCTGAGCCtctcc
 0 UGGCUCAG m7b Created no TS -0.032 -10.27
hsa-miR-2467-5p ctctcccctGAGCCTCtcc
 0 UGAGGCUC m7b (m6b->m7b) no TS -0.081 1.53
hsa-miR-3929 ctctccccTCAGCCTCtcc
 0 GAGGCUGA m8a Disrupted 0.005 no TS 10.87
hsa-miR-4419b ctctccccTCAGCCTCtcc
 0 GAGGCUGA m8a Disrupted -0.004 no TS 8.14
hsa-miR-4478 ctctccccTCAGCCTCtcc
 0 GAGGCUGA m8a Disrupted -0.013 no TS 4.83
hsa-miR-4518 ctctcCCCTGAGCctctcc
 0 GCUCAGGG m8a Created -0.372 -0.422 -1.56
hsa-miR-485-5p ctctcccctCAGCCTCTcc
 0 AGAGGCUG m8a (m8a->m7a) -0.048 no TS 14.54

Mutation Mutation ID Sample Name Cancer Type
chr18:g.48920671G>T COSN1206703 BN17T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-185-3p ttcctgcCAGCCCCTgcca
 6
 AGGGGCUG m8a Disrupted -0.148000 -0.047000 5.120000
hsa-miR-4492 ttcctgCCAGCCCCtgcca
 0 GGGGCUGG m8a Disrupted -0.084000 no TS 0.560000
hsa-miR-4498 ttcctgCCAGCCCctgcca
 0 UGGGCUGG m7b Disrupted -0.131000 no TS 0.160000
hsa-miR-5001-5p ttcctgCCAGCCCctgcca
 0 AGGGCUGG m7b Disrupted -0.121000 no TS 0.590000
hsa-miR-762 ttcctgCCAGCCCCtgcca
 0 GGGGCUGG m8a Disrupted -0.140000 no TS No effect
hsa-miR-185-3p ttcctgcCAGCCCCTgcca
 0 AGGGGCUG m8a Disrupted -0.148 -0.047 5.12
hsa-miR-4492 ttcctgCCAGCCCCtgcca
 0 GGGGCUGG m8a Disrupted -0.084 no TS 0.56
hsa-miR-4498 ttcctgCCAGCCCctgcca
 0 UGGGCUGG m7b Disrupted -0.131 no TS 0.16
hsa-miR-5001-5p ttcctgCCAGCCCctgcca
 0 AGGGCUGG m7b Disrupted -0.121 no TS 0.59
hsa-miR-762 ttcctgCCAGCCCCtgcca
 0 GGGGCUGG m8a Disrupted -0.14 no TS No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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