SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001256403
Gene Symbol:	SLMO2
Description:	Homo sapiens slowmo homolog 2 (Drosophila) (SLMO2), transcript variant 1, mRNA.
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr20:g.59034190T>A			COSN9145165		AOCS-005-1-8		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-182-5p	aaaTTGCCAAgtgtcaaaa	0	UUUGGCAA	m7b	(m6c->m7b)	no TS	-0.131000	-3.630000
hsa-miR-3117-5p	aaattgccaAGTGTCaaaa	0	AGACACUA	m6b	Created	no TS	-0.075000	-0.040000
hsa-miR-3614-5p	aaattgCCAAGTGtcaaaa	0	CCACUUGG	m7b	Created	-0.117000	-0.247000	-0.020000
hsa-miR-4643	aaattgcCATGTGTCaaaa	0	GACACAUG	m8a	Disrupted	-0.052000	no TS	5.590000
hsa-miR-4717-3p	aaattgCCATGTGTcaaaa	0	ACACAUGG	m8a	Disrupted	-0.106000	no TS	4.640000
hsa-miR-642a-3p	aaattgccATGTGTCaaaa	0	AGACACAU	m7b	Disrupted	-0.116000	no TS	7.200000
hsa-miR-642b-3p	aaattgccATGTGTCaaaa	0	AGACACAU	m7b	Disrupted	-0.116000	no TS	6.600000

Mutation			Mutation ID		Sample Name		Cancer Type
chr20:g.59034317G>A			COSN15382548		0071_CRUK_PC_0071_T1_DNA		[prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4641	tgctgtatCATGGGCtggt	0	UGCCCAUG	m7b	Created	no TS	-0.253000	0.420000

Mutation			Mutation ID		Sample Name		Cancer Type
chr20:g.59034743G>T			COSN1251266		HCC116T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-607	gaactccTTTGAAactggt	0	GUUCAAAU	m6b	Created	0.108000	0.143000	-0.110000
hsa-miR-607	gaactccTTTGAAactggt	0	GUUCAAAU	m6b	Created	0.108000	0.143000	-0.110000
hsa-miR-607	gaactccTTTGAAactggt	0	GUUCAAAU	m6b	Created	0.108	0.143	-0.11

Mutation			Mutation ID		Sample Name		Cancer Type
chr20:g.59034868T>A			COSN9145166		AOCS-119-3-9		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-103b	aaGGCTATGAgacttgatc	0	UCAUAGCC	m8a	(m7b->m8a)	-0.310000	-0.493000	0.060000
hsa-miR-1264	aaggctatgAGACTTGatc	0	CAAGUCUU	m7a	(m6a->m7a)	-0.128000	-0.128000	-2.220000
hsa-miR-224-5p	aaggctatGTGACTTGatc	0	CAAGUCAC	m8a	Disrupted	-0.195000	no TS	0.350000
hsa-miR-3184-3p	aaggctatGAGACTTgatc	0	AAAGUCUC	m7b	Created	no TS	-0.204000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr20:g.59034890G>T			9_64595		CRC-6-Tumor		Colorectal adenocarcinoma
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3163	ttttttTTTTATAagttgg	2	UAUAAAAU	m7a	Created	no TS	0.05	-0.01
hsa-miR-340-5p	tttttttTTTATAAgttgg	1	UUAUAAAG	m7a	Created	no TS	0.025	-0.1
hsa-miR-3613-3p	tttTTTTTTGataagttgg	3	ACAAAAAA	m7b	(m7b->m6c)	-0.049	0.07	-0.02

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
59034891	rs34173406	-	-	hsa-miR-3613-3p	0	tTTTTTTGAtaag	Unknown	N	No Change
			T
59034891	rs56791549	-	TTTT	hsa-miR-3613-3p	0	ttttTTTTTTGAtaagttg	Unknown	N	-0.006
			-
59034891	rs61461787	-	TTT	hsa-miR-3613-3p	0	tttTTTTTTGAtaagtt	Unknown	N	-0.004
			-

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