SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001112801
Gene Symbol: SLC8A1
Description: Homo sapiens solute carrier family 8 (sodium/calcium exchanger), member 1 (SLC8A1), transcript variant B, mRNA.
Gene Location: chr2(-):40339285-40657444
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr2:g.40112209T>C COSN10000183 C0021T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3150b-3p tttTCTCCTCtctcattgt
 4
 UGAGGAGA m7b (m6c->m7b) -0.010000 -0.254000 -1.630000
hsa-miR-4428 tttTCTCCTTtctcattgt
 0 CAAGGAGA m7b (m7b->m6c) -0.272000 no TS 0.010000
hsa-miR-4712-3p ttttctcctCTCTCATTgt
 0 AAUGAGAG m8a (m7a->m8a) no TS -0.206000 -1.380000
hsa-miR-4784 tttTCTCCTCtctcattgt
 4
 UGAGGAGA m7b (m6c->m7b) -0.019000 -0.263000 -2.580000
hsa-miR-539-5p ttttctccTTTCTCattgt
 2
 GGAGAAAU m6b Disrupted -0.060000 no TS 0.050000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.40112280A>T COSN8609211 4095_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4288 acaCAGACAAataaagttt
 0 UUGUCUGC m7a (m7a->m6b) -0.152000 no TS -0.010000
hsa-miR-654-3p acaCAGACATAtaaagttt
 8
 UAUGUCUG m8a Created 0.014000 -0.366000 -0.720000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.40112659->T ICGC_sm100013 RK015_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3613-3p ttttTTTTTTGagaattgc
 0 ACAAAAAA m7b Disrupted -0.014000 -0.016000 No effect
hsa-miR-371a-5p tttttttTTTGAGaattgc
 0 ACUCAAAC m6b Disrupted -0.019000 -0.020000 No effect
hsa-miR-371b-5p ttttttTTTTGAGaattgc
 0 ACUCAAAA m7b Disrupted 0.026000 0.025000 -0.010000
hsa-miR-373-5p ttttttTTTTGAGaattgc
 0 ACUCAAAA m7b Disrupted 0.035000 0.034000 -0.040000
hsa-miR-616-5p ttttttTTTTGAGaattgc
 0 ACUCAAAA m7b Disrupted 0.016000 0.015000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr2:g.40112659->TT ICGC_ssm_v2_10981 HX5T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3613-3p tttttTTTTTTGagaattgct
 0 ACAAAAAA m7b Disrupted -0.014000 -0.018000 No effect
hsa-miR-371a-5p ttttttttTTTGAGaattgct
 0 ACUCAAAC m6b Disrupted -0.019000 -0.022000 No effect
hsa-miR-371b-5p tttttttTTTTGAGaattgct
 0 ACUCAAAA m7b Disrupted 0.026000 0.022000 -0.080000
hsa-miR-373-5p tttttttTTTTGAGaattgct
 0 ACUCAAAA m7b Disrupted 0.035000 0.031000 -0.220000
hsa-miR-616-5p tttttttTTTTGAGaattgct
 0 ACUCAAAA m7b Disrupted 0.016000 0.012000 -0.020000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.40113273G>C COSN9373396 AOCS-088-3-8 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-15b-3p ctctgtatTGATTCaaaaa
 0 CGAAUCAU m6b Disrupted -0.134000 -0.133000 0.380000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.40113386C>G COSN8993317 8057646 [pancreas][NS][carcinoid-endocrine_tumour][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1 ccaACATTCCAaagtagtg
 0 UGGAAUGU m8a Disrupted -0.014000 0.031000 0.260000
hsa-miR-206 ccaACATTCCAaagtagtg
 0 UGGAAUGU m8a Disrupted -0.004000 0.031000 0.220000
hsa-miR-3673 ccaaCATTCCAaagtagtg
 8
 AUGGAAUG m7b Disrupted -0.034000 no TS 0.050000
hsa-miR-613 ccaACATTCCaaagtagtg
 0 AGGAAUGU m7b (m7b->m6c) -0.025000 0.031000 0.260000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.40113518A>G COSN7128644 8016470 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-125b-2-3p cctctACTTGTGctgaaag
 0 UCACAAGU m7b Created no TS 0.029000 -0.520000
hsa-miR-3065-3p cctctacttGTGCTGAaag
 0 UCAGCACC m7a (m6a->m7a) no TS -0.025000 -4.270000
hsa-miR-4310 cctctacttATGCTGaaag
 7
 GCAGCAUU m6b Disrupted -0.048000 -0.065000 0.860000
hsa-miR-5697 cctCTACTTGtgctgaaag
 0 UCAAGUAG m7b (m6c->m7b) no TS 0.036000 -0.830000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.40113558G>A COSN1839394 RK025_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3620 agaagcCAGGGTGAccaac
 4
 UCACCCUG m8a Disrupted -0.011000 no TS No effect
hsa-miR-514a-5p agaagCCAGAGTgaccaac
 0 UACUCUGG m7b Created no TS 0.018000 No effect
hsa-miR-668 agaagccaGAGTGACcaac
 0 UGUCACUC m7b Created no TS -0.010000 -7.490000
hsa-miR-3620 agaagcCAGGGTGAccaac
 4
 UCACCCUG m8a Disrupted -0.011000 no TS No effect
hsa-miR-514a-5p agaagCCAGAGTgaccaac
 0 UACUCUGG m7b Created no TS 0.018000 No effect
hsa-miR-668 agaagccaGAGTGACcaac
 0 UGUCACUC m7b Created no TS -0.010000 -7.490000
hsa-miR-3620 agaagcCAGGGTGAccaac
 0 UCACCCUG m8a Disrupted -0.011 no TS No effect
hsa-miR-514a-5p agaagCCAGAGTgaccaac
 0 UACUCUGG m7b Created no TS 0.018 No effect
hsa-miR-668 agaagccaGAGTGACcaac
 0 UGUCACUC m7b Created no TS -0.01 -7.49

Mutation Mutation ID Sample Name Cancer Type
chr2:g.40113882A>G COSN1839395 RK056_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-20b-3p caaACTACAGagatcttca
 0 ACUGUAGU m7b (m6c->m7b) no TS -0.008000 -2.420000
hsa-miR-3674 caaaCTACAAagatcttca
 5
 AUUGUAGA m6b Disrupted 0.065000 no TS No effect
hsa-miR-20b-3p caaACTACAGagatcttca
 0 ACUGUAGU m7b (m6c->m7b) no TS -0.008 -2.42
hsa-miR-3674 caaaCTACAAagatcttca
 0 AUUGUAGA m6b Disrupted 0.065 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr2:g.40114112A>G COSN6181335 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-625-3p gtagagTATAGTacatact
 11
 GACUAUAG m6b Disrupted 0.114000 0.084000 0.530000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.40114293G>C COSN9373397 AOCS-112-1-2 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4480 gttgCTTGGCattgtctgt
 0 AGCCAAGU m6b Created no TS -0.071000 -0.010000
hsa-miR-4733-5p gttgcTTGGGATTgtctgt
 0 AAUCCCAA m8a Disrupted -0.031000 -0.031000 4.160000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.40115087C>A COSN5503613 RK155_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1 catcacctcACATTCCcag
 0 UGGAAUGU m7b (m6b->m7b) -0.014000 -0.086000 -0.910000
hsa-miR-1294 catcACCTCACAttcccag
 0 UGUGAGGU m8a Created no TS -0.354000 -2.660000
hsa-miR-149-3p catcaCCTCCCattcccag
 7
 AGGGAGGG m6b Disrupted -0.170000 -0.031000 No effect
hsa-miR-206 catcacctcACATTCCcag
 0 UGGAAUGU m7b (m6b->m7b) -0.004000 -0.085000 -0.320000
hsa-miR-30b-3p catcaCCTCCCAttcccag
 7
 CUGGGAGG m7b Disrupted -0.299000 -0.055000 3.480000
hsa-miR-3689a-3p catcaCCTCCCAttcccag
 7
 CUGGGAGG m7b Disrupted -0.290000 -0.055000 0.290000
hsa-miR-3689b-3p catcaCCTCCCAttcccag
 7
 CUGGGAGG m7b Disrupted -0.300000 -0.065000 0.050000
hsa-miR-3689c catcaCCTCCCAttcccag
 7
 CUGGGAGG m7b Disrupted -0.300000 -0.065000 0.050000
hsa-miR-3689d catCACCTCCCattcccag
 7
 GGGAGGUG m8a Disrupted -0.388000 -0.159000 0.070000
hsa-miR-4316 catcaCCTCACattcccag
 0 GGUGAGGC m6b Created no TS -0.156000 -0.120000
hsa-miR-613 catcacctcACATTCCcag
 0 AGGAAUGU m7b (m6b->m7b) -0.025000 -0.097000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr2:g.40115237T>G COSN1839396 RK092_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-5684 tatcagaTAGAGTaaattt
 14
 AACUCUAG m6b Created -0.044000 -0.088000 No effect
hsa-miR-625-3p tatcagaTATAGTaaattt
 11
 GACUAUAG m6b Disrupted 0.114000 0.076000 No effect
hsa-miR-5684 tatcagaTAGAGTaaattt
 0 AACUCUAG m6b Created -0.044 -0.088 No effect
hsa-miR-625-3p tatcagaTATAGTaaattt
 0 GACUAUAG m6b Disrupted 0.114 0.076 No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
40112658 rs192167218 G G hsa-miR-3613-3p
hsa-miR-371a-5p
hsa-miR-371b-5p
hsa-miR-372-5p
hsa-miR-373-5p
hsa-miR-513c-5p
hsa-miR-514b-5p
hsa-miR-5571-5p
hsa-miR-616-5p
0 TTTTTTGAgaatt
tttTTTGAGAatt
ttTTTTGAGAatt
tttTTTGAGAatt
ttTTTTGAGAatt
ttttTTGAGAAtt
ttttTTGAGAAtt
ttttttGAGAATT
ttTTTTGAGAatt
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
N
 0.015
-0.019
-0.1
-0.023
-0.1
-0.059
-0.063
-0.089
-0.1
T hsa-miR-4799-5p
2
 ttttTTTAGAAtt
 Created
N
 0.006
40112659 rs56384807 - - hsa-miR-3613-3p
hsa-miR-371a-5p
hsa-miR-371b-5p
hsa-miR-372-5p
hsa-miR-373-5p
hsa-miR-513c-5p
hsa-miR-514b-5p
hsa-miR-616-5p
3
9
6
9
6
11
11
6
 ttTTTTTTGAgaatt
tttttTTTGAGAatt
ttttTTTTGAGAatt
tttttTTTGAGAatt
ttttTTTTGAGAatt
ttttttTTGAGAAtt
ttttttTTGAGAAtt
ttttTTTTGAGAatt
 Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
N
N
N
N
N
N
N
N
 0.004
0.003
0.004
0.003
0.004
0.003
-0.001
0.004
TT
40113389 rs146999384 T T hsa-miR-1
hsa-miR-206
hsa-miR-3673
hsa-miR-409-3p
hsa-miR-4781-3p
hsa-miR-613
hsa-miR-6505-5p
10
10
10
8
8
10
10
 ccaACATTCCAaa
ccaACATTCCAaa
ccaaCATTCCAAa
cCAACATTccaaa
CCAACATtccaaa
ccaACATTCCAaa
ccaacATTCCAAa
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
 -0.045
-0.035
-0.034
0.095
No Change
-0.056
0.015
C hsa-miR-122-5p
hsa-miR-3198
hsa-miR-3659
hsa-miR-4309
hsa-miR-504-3p
10
10
10
10
10
 ccaACACTCCAaa
ccaacACTCCAAa
ccAACACTCcaaa
ccaacACTCCAAa
ccaaCACTCCAaa
 Created
Created
Created
Created
Created
N
N
N
N
N
 -0.112
-0.04
0.016
-0.04
-0.047
40113464 rs184490718 T T hsa-miR-455-3p
hsa-miR-4733-5p
2
0
 tTGGACTGggata
ttggacTGGGATA
 Disrupted
Disrupted
N
N
 -0.031
-0.031
C hsa-miR-4783-3p
6
 ttggACCGGGAta
 Created
N
 -0.156
40115093 rs72558068 C C hsa-miR-3689d
hsa-miR-6851-5p
hsa-miR-7854-3p
hsa-miR-8069
11
11
11
9
 aaccatCACCTCC
aaccatCACCTCC
aaccaTCACCTCc
AACCATCAcctcc
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.229
-0.22
-0.142
-0.331

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