SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_003615
Gene Symbol: SLC4A7
Description: Homo sapiens solute carrier family 4, sodium bicarbonate cotransporter, member 7 (SLC4A7), mRNA.
Gene Location: chr3(-):27414213-27498245
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr3:g.27373016A>T COSN14909020 LP6005409-DNA_F02 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-16-2-3p ataaataAATATTGaattt
 0 CCAAUAUU m7b Created 0.006000 -0.190000 No effect
hsa-miR-195-3p ataaataAATATTGaattt
 0 CCAAUAUU m7b Created 0.009000 -0.166000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr3:g.27373270A>G ICGC_531839 TCGA-A6-2672-01A-01W-0833-10 ColonAdenocarcinoma(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4659a-5p cattaaATGGCAattatag
 0 CUGCCAUG m6b Created no TS -0.143 -3.38
hsa-miR-4776-3p cattaaATGGCAAttatag
 0 CUUGCCAU m7b Created no TS -0.221 -0.05
hsa-miR-489 cattaaATGTCAattatag
 0 GUGACAUC m6b Disrupted -0.099 no TS 0.11

Mutation Mutation ID Sample Name Cancer Type
chr3:g.27373326G>T ICGC_434377 TCGA-AZ-6600-01A-11D-1771-10 ColonAdenocarcinoma(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-192-3p caaaatTTGGCAatcttca
 0 CUGCCAAU m6b Disrupted -0.148 -0.024 No effect

Mutation Mutation ID Sample Name Cancer Type
chr3:g.27373327G>A ICGC_406828 TCGA-AA-3697-01A-01D-1719-10 ColonAdenocarcinoma(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-192-3p gcaaaatTTGGCAatcttc
 0 CUGCCAAU m6b Disrupted -0.148 -0.024 0.01

Mutation Mutation ID Sample Name Cancer Type
chr3:g.27374015T>C COSN6573947 ICGC_MB82 [central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-889 ttaatGATATTAAatatgc
 2
 UUAAUAUC m8a Disrupted 0.068000 no TS 0.950000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.27374120A>T COSN6764222 RK216_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3133 ctgaaatGTTCTTTttttc
 4
 UAAAGAAC m7b Created 0.435000 0.484000 -0.120000
hsa-miR-548av-5p ctgaaatGTACTTTTtttc
 2
 AAAAGUAC m8a Disrupted 0.149000 0.167000 1.470000
hsa-miR-548k ctgaaatGTACTTTTtttc
 2
 AAAAGUAC m8a Disrupted 0.149000 0.167000 4.020000
hsa-miR-548n ctgaaatgTACTTTTtttc
 5
 CAAAAGUA m7b Disrupted 0.242000 0.130000 2.970000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.27375847C>A ICGC_398619 TCGA-AA-3492-01A-01D-1408-10 ColonAdenocarcinoma(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4764-3p tcaGGAGTTAgaattctct
 0 UUAACUCC m7b (m7b->m6c) -0.107 -0.107 No effect


Mutation Mutation ID Sample Name Cancer Type
chr3:g.27376240G>A COSN6764223 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr3:g.27376615C>G COSN1275459 HCC115T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1250 aatgAGCACCGTggagact
 4
 ACGGUGCU m8a Disrupted -0.298000 no TS 0.470000
hsa-miR-3907 aatGAGCACCgtggagact
 11
 AGGUGCUC m7b (m7b->m6c) -0.289000 no TS 6.710000
hsa-miR-1250 aatgAGCACCGTggagact
 4
 ACGGUGCU m8a Disrupted -0.298000 no TS 0.470000
hsa-miR-3907 aatGAGCACCgtggagact
 11
 AGGUGCUC m7b (m7b->m6c) -0.289000 no TS 6.710000
hsa-miR-1250 aatgAGCACCGTggagact
 0 ACGGUGCU m8a Disrupted -0.298 no TS 0.47
hsa-miR-3907 aatGAGCACCgtggagact
 0 AGGUGCUC m7b (m7b->m6c) -0.289 no TS 6.71

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
27375688 rs41295960 A A hsa-miR-190a-3p
hsa-miR-369-3p
hsa-miR-374a-5p
hsa-miR-374b-5p
hsa-miR-410-3p
hsa-miR-5692b
hsa-miR-5692c
hsa-miR-6083
7
4
4
4
6
4
4
6
 aatatTATATAAa
aaTATTATAtaaa
aaTATTATAtaaa
aaTATTATAtaaa
aataTTATATAaa
aATATTATAtaaa
aATATTATAtaaa
aatattATATAAA
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
 0.102
0.072
0.01
0.001
0.083
0.073
0.073
0.1
G hsa-let-7a-3p
hsa-let-7b-3p
hsa-let-7f-1-3p
hsa-let-7f-2-3p
hsa-miR-1185-1-3p
hsa-miR-1185-2-3p
hsa-miR-16-2-3p
hsa-miR-195-3p
hsa-miR-300
hsa-miR-338-5p
hsa-miR-381-3p
hsa-miR-4666a-3p
hsa-miR-4789-5p
hsa-miR-98-3p
6
6
6
7
7
7
4
4
6
4
6
4
7
6
 aataTTGTATAAa
aataTTGTATAAa
aataTTGTATAAa
aatatTGTATAAa
aatatTGTATAAa
aatatTGTATAAa
AATATTGtataaa
AATATTGtataaa
aataTTGTATAaa
aATATTGTAtaaa
aataTTGTATAaa
aatATTGTATAaa
aatatTGTATAAa
aataTTGTATAAa
 Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
N
N
N
N
N
N
 0.013
-0.008
-0.029
0.03
0.023
0.023
-0.025
-0.016
0.036
-0.015
0.023
-0.012
0.021
-0.008

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