SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_021977
Gene Symbol: SLC22A3
Description: Homo sapiens solute carrier family 22 (extraneuronal monoamine transporter), member 3 (SLC22A3), mRNA.
Gene Location: chr6(+):160769424-160876014
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr6:g.160451119C>T COSN14848669 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-124-3p aaagctGTGCCTTgcagag
 9
 UAAGGCAC m7b Disrupted -0.164000 no TS 2.160000
hsa-miR-4696 aaagctgtGTCTTGCAgag
 0 UGCAAGAC m8a Created no TS -0.359000 -0.040000
hsa-miR-4708-3p aaagctgtGCCTTGCagag
 1
 AGCAAGGC m7b Disrupted -0.627000 -0.192000 0.120000
hsa-miR-506-3p aaagctGTGCCTTgcagag
 9
 UAAGGCAC m7b Disrupted -0.164000 no TS 2.950000
hsa-miR-5582-5p aaagcTGTGCCTtgcagag
 7
 UAGGCACA m7b Disrupted -0.166000 no TS 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.160451249G>- ICGC_ssm_v3_32729 HCC107T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4272 gctGTTGAATttctggga
 0 CAUUCAAC m7b (m6b->m7b) 0.134000 -0.003000 -0.030000
hsa-miR-676-5p gctGTTGAAGtttctggga
 2
 UCUUCAAC m7b (m7b->m6b) -0.103000 0.060000 0.170000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.160451477G>T COSN9499752 AOCS-088-3-8 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2114-5p tctggtcaAGGGACTAagc
 0 UAGUCCCU m8a Disrupted -0.341000 no TS No effect
hsa-miR-4780 tctggTCAAGGGactaagc
 0 ACCCUUGA m7b Disrupted -0.296000 no TS No effect
hsa-miR-5588-3p tctggtcaaGGGACTaagc
 0 AAGUCCCA m6b Disrupted -0.285000 -0.140000 0.640000
hsa-miR-623 tctggtCAAGGGActaagc
 0 AUCCCUUG m7b Disrupted -0.149000 -0.001000 No effect


Mutation Mutation ID Sample Name Cancer Type
chr6:g.160451494T>C COSN7786940 PCSI_0356_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr6:g.160451620G>A COSN14902770 CHC433T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-147a ttggtttCCACACACcttc
 0 GUGUGUGG m8a Created no TS -0.118000 -0.480000
hsa-miR-147b ttggtttCCGCACACcttc
 0 GUGUGCGG m8a Disrupted -0.238000 no TS 5.220000
hsa-miR-3650 ttggtttccACACACCTtc
 1
 AGGUGUGU m8a (m7b->m8a) -0.222000 -0.324000 0.020000
hsa-miR-3911 ttggttTCCACACAccttc
 0 UGUGUGGA m8a Created no TS -0.265000 -0.070000
hsa-miR-3978 ttggTTTCCACacaccttc
 0 GUGGAAAG m7a Created NA NA -0.280000
hsa-miR-644a ttggtttCCACACaccttc
 0 AGUGUGGC m6b Created no TS -0.089000 -0.040000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.160451659G>T COSN9499753 AOCS-115-1-0 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1321 gtcCCTCCCTtccacctcc
 0 CAGGGAGG m7b (m6b->m7b) no TS -0.098000 No effect
hsa-miR-149-3p gtCCCTCCCTtccacctcc
 0 AGGGAGGG m8a (m7a->m8a) -0.138000 -0.166000 No effect
hsa-miR-3190-3p gtccctccCTTCCACctcc
 0 UGUGGAAG m7b Created no TS -0.032000 No effect
hsa-miR-3202 gtccctCCCTTCCAcctcc
 4
 UGGAAGGG m8a Created -0.224000 -0.422000 No effect
hsa-miR-4739 gtcCCTCCCTTccacctcc
 0 AAGGGAGG m8a Created no TS -0.079000 0.120000
hsa-miR-4756-5p gtcCCTCCCTtccacctcc
 0 CAGGGAGG m7b (m6b->m7b) no TS -0.098000 No effect
hsa-miR-4804-5p gtccctcCCGTCCAcctcc
 2
 UUGGACGG m7b Disrupted -0.346000 -0.192000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr6:g.160453068C>G COSN9499754 AOCS-149-1-7 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2276 gtgacCTTGCAGcctgctc
 3
 UCUGCAAG m7b Disrupted -0.270000 -0.321000 2.380000
hsa-miR-3155a gtgaccttgGAGCCTGctc
 0 CCAGGCUC m7b (m6c->m7b) no TS 0.026000 -2.180000
hsa-miR-3155b gtgaccttgGAGCCTGctc
 0 CCAGGCUC m7b (m6c->m7b) no TS 0.026000 -3.450000
hsa-miR-4708-3p gtgaCCTTGCagcctgctc
 1
 AGCAAGGC m6b Disrupted -0.627000 -0.678000 0.030000
hsa-miR-484 gtgaccttgGAGCCTGctc
 0 UCAGGCUC m7b (m6c->m7b) no TS 0.035000 -0.160000
hsa-miR-5695 gtgacCTTGGAGcctgctc
 0 ACUCCAAG m7b Created -0.184000 -0.063000 -0.040000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.160453456G>T COSN1083954 TCGA-AP-A059-01 [endometrium][NS][carcinoma][endometrioid_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2053 tcaatccaATTAACAaacc
 3
 GUGUUAAU m7b Created 0.082000 0.313000 -1.220000
hsa-miR-5004-3p tcAATCCAAGtaacaaacc
 13
 CUUGGAUU m8a (m8a->m7a) 0.081000 0.054000 -0.060000
hsa-miR-569 tcaatccaATTAACaaacc
 2
 AGUUAAUG m6b Created 0.016000 0.141000 -1.030000
hsa-miR-890 tcaaTCCAAGTAacaaacc
 5
 UACUUGGA m8a Disrupted -0.003000 no TS 4.480000
hsa-miR-2053 tcaatccaATTAACAaacc
 0 GUGUUAAU m7b Created 0.082 0.313 -1.22
hsa-miR-5004-3p tcAATCCAAGtaacaaacc
 0 CUUGGAUU m8a (m8a->m7a) 0.081 0.054 -0.06
hsa-miR-569 tcaatccaATTAACaaacc
 0 AGUUAAUG m6b Created 0.016 0.141 -1.03
hsa-miR-890 tcaaTCCAAGTAacaaacc
 5
 UACUUGGA m8a Disrupted -0.003 no TS 4.48

Mutation Mutation ID Sample Name Cancer Type
chr6:g.160453522G>T COSN1083953 TCGA-BS-A0UV-01 [endometrium][NS][carcinoma][endometrioid_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4260 agaCCCCAAGaagtgactc
 2
 CUUGGGGC m7a (m7a->m6a) -0.442000 -0.442000 No effect
hsa-miR-450a-3p agaCCCCAATaagtgactc
 2
 AUUGGGGA m7a (m6a->m7a) -0.072000 -0.072000 No effect
hsa-miR-635 agacCCCAAGaagtgactc
 2
 ACUUGGGC m6b Disrupted -0.026000 -0.038000 0.010000
hsa-miR-4260 agaCCCCAAGaagtgactc
 0 CUUGGGGC m7a (m7a->m6a) -0.442 -0.442 No effect
hsa-miR-450a-3p agaCCCCAATaagtgactc
 0 AUUGGGGA m7a (m6a->m7a) -0.072 -0.072 No effect
hsa-miR-635 agacCCCAAGaagtgactc
 14
 ACUUGGGC m6b Disrupted -0.026 -0.038 0.01

Mutation Mutation ID Sample Name Cancer Type
chr6:g.160454086G>A COSN1328064 HCC125T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4738-3p atctaggCAGTTTCtaaac
 0 UGAAACUG m7b Disrupted -0.016000 no TS No effect
hsa-miR-4774-3p atcTAGGCAATttctaaac
 6
 AUUGCCUA m8a Created -0.059000 -0.151000 0.010000
hsa-miR-548av-3p atctagGCAGTTTctaaac
 0 AAAACUGC m7b Disrupted -0.075000 -0.054000 No effect
hsa-miR-5680 atctaggcaATTTCTaaac
 3
 GAGAAAUG m6b Created 0.163000 0.265000 No effect
hsa-miR-4738-3p atctaggCAGTTTCtaaac
 0 UGAAACUG m7b Disrupted -0.016 no TS No effect
hsa-miR-4774-3p atcTAGGCAATttctaaac
 0 AUUGCCUA m8a Created -0.059 -0.151 0.01
hsa-miR-548av-3p atctagGCAGTTTctaaac
 0 AAAACUGC m7b Disrupted -0.075 -0.054 No effect
hsa-miR-5680 atctaggcaATTTCTaaac
 0 GAGAAAUG m6b Created 0.163 0.265 No effect

Mutation Mutation ID Sample Name Cancer Type
chr6:g.160454838T>A COSN9499755 AOCS-119-3-9 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
160451119 rs1810126 C C hsa-miR-124-3p
hsa-miR-4708-3p
hsa-miR-506-3p
hsa-miR-5582-5p
9
9
9
7
 gctGTGCCTTgca
gctgtGCCTTGCA
gctGTGCCTTgca
gcTGTGCCTtgca
 Disrupted
Disrupted
Disrupted
Disrupted
HT
N
N
N
 -0.164
-0.435
-0.164
-0.166
T hsa-miR-4696
9
 gctgtGTCTTGCA
 Created
N
 -0.359
160451479 rs185463021 G G hsa-miR-2114-5p
hsa-miR-4540
hsa-miR-4780
hsa-miR-5588-3p
hsa-miR-623
hsa-miR-6723-5p
hsa-miR-6780b-3p
2
1
2
2
3
1
3
 tcaAGGGACTAag
tcaagGGACTAAg
TCAAGGGActaag
tcaaGGGACTAag
tCAAGGGActaag
tcaagGGACTAAg
tCAAGGGActaag
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
 -0.341
-0.126
-0.296
-0.145
-0.148
-0.15
-0.118
A hsa-miR-502-5p
3
 tCAAGGAActaag
 Created
N
 -0.062
160451620 rs3088442 A G hsa-miR-147b
hsa-miR-6850-5p
1
1
 gtttCCGCACAcc
gtTTCCGCAcacc
 Created
Created
N
N
 -0.238
-0.206
A hsa-miR-147a
hsa-miR-3190-3p
hsa-miR-3650
hsa-miR-3911
hsa-miR-4261
hsa-miR-644a
hsa-miR-6833-5p
hsa-miR-6867-5p
1
1
2
1
1
3
1
1
 gtttCCACACAcc
gtTTCCACAcacc
gtttccACACACC
gttTCCACACAcc
GTTTCCAcacacc
gtttCCACACAcc
gtTTCCACAcacc
gtttcCACACACc
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
 -0.118
-0.028
-0.102
-0.265
-0.024
-0.089
-0.09
-0.08

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