SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_153187
Gene Symbol:	SLC22A1
Description:	Homo sapiens solute carrier family 22 (organic cation transporter), member 1 (SLC22A1), transcript variant 1, mRNA.
Gene Location:	chr6(+):160542862-160579750
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.160158561C>A			ICGC_1347866		TCGA-AP-A059-01A-21D-A122-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-377-5p	ggtccaAACCTCagaaccc	0	AGAGGUUG	m6b	Disrupted	0	no TS	No effect
hsa-miR-4464	ggtcCAAACCTcagaaccc	0	AAGGUUUG	m7b	Disrupted	0	no TS	No effect
hsa-miR-4502	ggtccaaaCATCAGaaccc	0	GCUGAUGA	m6b	Created	no TS	0	No effect
hsa-miR-4649-3p	ggtccaaaCCTCAGAaccc	0	UCUGAGGC	m7a	Disrupted	0	no TS	No effect
hsa-miR-4748	ggtcCAAACCTCagaaccc	0	GAGGUUUG	m8a	Disrupted	0	no TS	No effect
hsa-miR-4762-3p	ggtccaaacATCAGAAccc	0	CUUCUGAU	m7b	(m6c->m7b)	no TS	0	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.160158599C>T			COSN4857176		tumor_4121361		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3913-3p	gttttgcggTGATGTCgtg	0	AGACAUCA	m7b	(m6c->m7b)	no TS	-0.107000	-1.010000
hsa-miR-499a-3p	gttttgcgGTGATGTcgtg	0	AACAUCAC	m7b	Created	no TS	-0.093000	-7.420000
hsa-miR-499b-3p	gttttgcgGTGATGTcgtg	0	AACAUCAC	m7b	Created	no TS	-0.093000	-15.240000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
160158564	rs16891138	A	A	hsa-miR-152-5p hsa-miR-377-5p hsa-miR-4303 hsa-miR-4649-3p hsa-miR-6086 hsa-miR-655-5p hsa-miR-7162-3p	6 1 2 2 1 1 2	aacctCAGAACCc AACCTCAgaaccc aacCTCAGAAccc aaCCTCAGAaccc AACCTCAgaaccc AACCTCAgaaccc aACCTCAGAaccc	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N	No Change No Change No Change No Change No Change No Change No Change

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