SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001128588
Gene Symbol:	SLC14A1
Description:	Homo sapiens solute carrier family 14 (urea transporter), member 1 (Kidd blood group) (SLC14A1), transcript variant 1, mRNA.
Gene Location:	chr18(+):43304091-43332485
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr18:g.45751222T>C			ICGC_B0992398-2A78-11E2-8335-12FD496BB9B8		CPCG_0102_Pr_P_P2		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3199	gcctgtAGTCCCagctact	0	AGGGACUG	m6b	Created	-0.129	-0.127	No effect
hsa-miR-365a-5p	gcctgtAGTCCCagctact	0	AGGGACUU	m6b	Created	no TS	-0.008	No effect
hsa-miR-365b-5p	gcctgtAGTCCCagctact	0	AGGGACUU	m6b	Created	no TS	-0.008	-0.64

Mutation			Mutation ID		Sample Name		Cancer Type
chr18:g.45751356A>C			9_36386		CRC-4-Tumor		Colorectal adenocarcinoma
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-5010-3p	aaaaaaaaACACAAAcaaa	1	UUUUGUGU	m7b	Created	-0.086	-0.141	-3.15
hsa-miR-599	aaaaaaaaACACAAacaaa	1	GUUGUGUC	m6b	Created	-0.067	-0.074	-1.0

Mutation			Mutation ID		Sample Name		Cancer Type
chr18:g.45752178G>C			COSN6124676		RK162_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-642b-5p	tcttgttAGGGAACgtgtg	2	GGUUCCCU	m7b	Disrupted	-0.432000	-0.198000	No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
45750829	rs16978481	C	C	hsa-miR-1256 hsa-miR-3688-5p hsa-miR-4474-3p hsa-miR-7108-5p hsa-miR-891a-3p	4 3 4 4 3	taAATGCCAcaaa taaaTGCCACAaa taaatGCCACAAa taaatGCCACAAa taaaTGCCACAaa	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.073 -0.131 -0.125 -0.123 -0.123
			A	hsa-miR-4729 hsa-miR-5010-3p hsa-miR-5696 hsa-miR-592 hsa-miR-597-5p hsa-miR-599 hsa-miR-616-3p	5 4 5 3 3 4 4	TAAATGAcacaaa taaatgACACAAA TAAATGAcacaaa taaaTGACACAAa taaaTGACACAaa taaatGACACAAA taAATGACAcaaa	Created Created Created Created Created Created Created	N N N N N N N	0.081 -0.025 0.057 -0.23 -0.088 -0.202 -0.013

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