SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001145097
Gene Symbol:	SKIL
Description:	Homo sapiens SKI-like oncogene (SKIL), transcript variant 2, mRNA.
Gene Location:	chr3(+):170077410-170110950
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.170392512G>A			COSN1271799		BN37T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-491-3p	tatcTGCATAAcgataact	0	CUUAUGCA	m7b	Created	no TS	-0.161000	No effect
hsa-miR-491-3p	tatcTGCATAAcgataact	0	CUUAUGCA	m7b	Created	no TS	-0.161	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.170393158C>T			COSN7626575		PCSI_0112_Pa_P		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3613-3p	tgataaTTTTTGaactttt	0	ACAAAAAA	m6b	Created	0.450000	0.539000	No effect
hsa-miR-5000-5p	tgataatttCTGAACTttt	0	CAGUUCAG	m7b	(m7b->m6c)	-0.154000	0.026000	0.180000
hsa-miR-548c-3p	tgataATTTTTGaactttt	0	CAAAAAUC	m7a	Created	0.929000	0.929000	-0.350000

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.170393533A>T			COSN6753123		RK119_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-141-5p	aagttttaGAAGATaaagg	0	CAUCUUCC	m6b	Disrupted	-0.047000	-0.050000	No effect
hsa-miR-4799-5p	aagtTTTAGAagataaagg	0	AUCUAAAU	m6b	Disrupted	0.574000	0.491000	0.100000

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.170394830G>T			COSN5527755		RK090_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-216b	aacaatatAGAGATTTtgt	0	AAAUCUCU	m8a	Disrupted	0.000000	0.000000	5.230000
hsa-miR-3675-3p	aacaataTAGAGATtttgt	0	CAUCUCUA	m7b	Disrupted	-0.013000	no TS	1.950000

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.170395192A>T			COSN7834917		8069120		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4724-3p	tactctataAAGGTAataa	0	GUACCUUC	m6b	Disrupted	-0.126000	-0.137000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.170396116C>A			COSN9532982		AOCS-138-3-X		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-374b-3p	gtagTGCTAAaatttttga	0	CUUAGCAG	m6b	Created	-0.184000	-0.259000	No effect
hsa-miR-4282	gtagtgctaAAATTTTtga	0	UAAAAUUU	m7b	(m6c->m7b)	1.513000	1.585000	-0.010000
hsa-miR-5682	gtaGTGCTACaatttttga	0	GUAGCACC	m7a	(m7a->m6a)	no TS	-0.147000	-0.340000
hsa-miR-590-3p	gtagtgcTAAAATTtttga	0	UAAUUUUA	m7b	Created	0.526000	0.636000	-0.010000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
170393115	rs76966343	T	T	hsa-miR-548c-3p	2	taGATTTTTtttt	Disrupted	N	-0.004
170394579	rs182300409	A	A	hsa-miR-4282 hsa-miR-4720-3p hsa-miR-4804-3p	17 17 17	AATTTTAagcagt aattTTAAGCAgt aattTTAAGCAgt	Disrupted Disrupted Disrupted	N N N	0.146 0.034 0.04
			T	hsa-miR-548c-3p	17	aATTTTTAgcagt	Created	N	0.24
170396027	rs73879199	G	G	hsa-miR-3613-3p hsa-miR-520d-5p hsa-miR-524-5p	17 17 17	TTTTTTGtaaatc tttTTTGTAAatc tttTTTGTAAatc	Disrupted Disrupted Disrupted	N N N	0.001 0.043 0.043

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