SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001143676
Gene Symbol:	SGK1
Description:	Homo sapiens serum/glucocorticoid regulated kinase 1 (SGK1), transcript variant 2, mRNA.
Gene Location:	chr6(-):134490383-134639196
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.134169271A>C			COSN2142575		RK130_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-137	gtttGCAATAAaaccttga	20	UUAUUGCU	m7a	Disrupted	-0.132000	no TS	1.060000
hsa-miR-32-5p	gttTGCAATAaaaccttga	20	UAUUGCAC	m7a	(m7a->m6b)	-0.132000	no TS	0.770000
hsa-miR-4464	gtttgcaatCAAACCTTga	0	AAGGUUUG	m8a	(m7a->m8a)	no TS	-0.261000	-0.100000
hsa-miR-4748	gtttgcaatCAAACCTtga	0	GAGGUUUG	m7b	(m6b->m7b)	no TS	-0.224000	-0.150000
hsa-miR-92a-3p	gttTGCAATAaaaccttga	20	UAUUGCAC	m7a	(m7a->m6b)	-0.126000	no TS	0.090000
hsa-miR-92b-3p	gttTGCAATAaaaccttga	20	UAUUGCAC	m7a	(m7a->m6b)	-0.126000	no TS	0.250000
hsa-miR-137	gtttGCAATAAaaccttga	0	UUAUUGCU	m7a	Disrupted	-0.132	no TS	1.06
hsa-miR-32-5p	gttTGCAATAaaaccttga	0	UAUUGCAC	m7a	(m7a->m6b)	-0.132	no TS	0.77
hsa-miR-4464	gtttgcaatCAAACCTTga	0	AAGGUUUG	m8a	(m7a->m8a)	no TS	-0.261	-0.1
hsa-miR-4748	gtttgcaatCAAACCTtga	0	GAGGUUUG	m7b	(m6b->m7b)	no TS	-0.224	-0.15
hsa-miR-92a-3p	gttTGCAATAaaaccttga	0	UAUUGCAC	m7a	(m7a->m6b)	-0.126	no TS	0.09
hsa-miR-92b-3p	gttTGCAATAaaaccttga	0	UAUUGCAC	m7a	(m7a->m6b)	-0.126	no TS	0.25

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.134169677C>T			COSN9297750		AOCS-109-1-X		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-451a	tgtaagatACGGTTaataa	0	AAACCGUU	m6b	Disrupted	-0.238000	no TS	4.450000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.134169929G>A			COSN15010832		SM-4B296		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
134169676	rs7754021	G	G	hsa-miR-451a	0	agatACGGTTAat	Disrupted	N	-0.238

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