SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_015559
Gene Symbol: SETBP1
Description: Homo sapiens SET binding protein 1 (SETBP1), transcript variant 2, mRNA.
Gene Location: chr18(+):42260862-42648475
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr18:g.45063760C>T COSN9335218 AOCS-155-3-5 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4267 gcagtGAGCTGGggcgggg
 6
 UCCAGCUC m7b Created -0.040000 -0.163000 -1.510000
hsa-miR-4284 gcaGTGAGCCggggcgggg
 5
 GGGCUCAC m7b (m7b->m6b) -0.240000 -0.104000 0.010000
hsa-miR-4707-5p gcagtgaGCCGGGGCgggg
 0 GCCCCGGC m8a Disrupted -0.293000 no TS -0.470000

Mutation Mutation ID Sample Name Cancer Type
chr18:g.45064051A>C COSN1744136 RK086_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3646 cccgatTTCATTTgctggc
 0 AAAAUGAA m7b Disrupted 0.081000 no TS No effect
hsa-miR-3646 cccgatTTCATTTgctggc
 0 AAAAUGAA m7b Disrupted 0.081 no TS 0.02

Mutation Mutation ID Sample Name Cancer Type
chr18:g.45066572A>G COSN6664708 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-20a-3p ggccAATGCAGcttacaga
 12
 ACUGCAUU m7b Disrupted 0.129000 0.005000 No effect
hsa-miR-22-3p ggccaatGCAGCTTacaga
 0 AAGCUGCC m7a Disrupted NA NA 0.060000
hsa-miR-320e ggccaatgCAGCTTacaga
 2
 AAAGCUGG m6b Disrupted 0.069000 no TS -0.580000
hsa-miR-33a-5p ggcCAATGCAgcttacaga
 2
 GUGCAUUG m7b (m7b->m6b) 0.154000 no TS 0.040000
hsa-miR-33b-5p ggcCAATGCAgcttacaga
 2
 GUGCAUUG m7b (m7b->m6b) 0.154000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr18:g.45066920G>C COSN14505639 8070208 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1324 cttgactaaCTGTCTGGaa
 0 CCAGACAG m8a (m7b->m8a) -0.053000 -0.053000 -0.400000

Mutation Mutation ID Sample Name Cancer Type
chr18:g.45067026G>A COSN8251516 PCSI_0347_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-192-5p agaagaaAGGTCAaaggaa
 5
 CUGACCUA m6b Disrupted -0.011000 no TS 1.350000
hsa-miR-215 agaagaaAGGTCAaaggaa
 5
 AUGACCUA m6b Disrupted -0.011000 no TS 0.580000

Mutation Mutation ID Sample Name Cancer Type
chr18:g.45067418C>A COSN15240216 LP6005334-DNA_G03 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3674 aagTCTACAAacatatttc
 0 AUUGUAGA m7b (m6b->m7b) no TS -0.041000 -0.080000
hsa-miR-4307 aagtctacAAACATatttc
 20
 AAUGUUUU m6b Created 0.161000 0.241000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr18:g.45067616G>T COSN15240966 LP6005334-DNA_G03 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3607-3p gagcTTACAGataatgtca
 13
 ACUGUAAA m6b Disrupted 0.274000 0.249000 0.140000
hsa-miR-3686 gagcTTACAGATaatgtca
 13
 AUCUGUAA m8a Disrupted 0.264000 0.228000 0.300000
hsa-miR-3924 gagctTACATATaatgtca
 20
 AUAUGUAU m7a Created 0.046000 0.046000 0.010000
hsa-miR-4495 gagcTTACATataatgtca
 0 AAUGUAAA m6b Created no TS 0.063000 -0.040000
hsa-miR-4528 gagcttacaTATAATGtca
 15
 UCAUUAUA m7b (m6c->m7b) 0.092000 0.111000 -5.140000


Mutation Mutation ID Sample Name Cancer Type
chr18:g.45067930G>C COSN9838990 C0010T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr18:g.45068161A>C COSN9335219 AOCS-108-1-7 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-375 acatattttCGAACAAAaa
 0 UUUGUUCG m8a (m7b->m8a) -0.108000 -0.324000 No effect
hsa-miR-4273 acatattttAGAACAaaaa
 0 GUGUUCUC m6b Disrupted -0.114000 no TS 0.030000
hsa-miR-4677-5p acatattttAGAACAAaaa
 0 UUGUUCUU m7a (m7a->m6b) -0.117000 no TS No effect
hsa-miR-4799-5p acatatTTTAGAacaaaaa
 16
 AUCUAAAU m6b Disrupted -0.029000 no TS 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr18:g.45068302G>A COSN5845995 HX30T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
45065443 rs73431734 A A hsa-miR-1207-3p
hsa-miR-4267
hsa-miR-4281
hsa-miR-6131
hsa-miR-7152-3p
6
6
7
7
6
 gggaCCAGCTGga
gggaccAGCTGGA
GGGACCAgctgga
ggGACCAGCtgga
gGGACCAGctgga
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
 -0.05
-0.016
-0.063
-0.006
-0.037
T hsa-miR-214-3p
hsa-miR-338-3p
hsa-miR-3619-5p
hsa-miR-4530
hsa-miR-761
6
6
6
6
6
 gggaCCTGCTGga
gggaccTGCTGGA
gggaCCTGCTGga
gggacCTGCTGGA
gggaCCTGCTGga
 Created
Created
Created
Created
Created
N
N
N
N
N
 -0.042
-0.024
-0.042
-0.015
-0.08

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