SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_152754
Gene Symbol: SEMA3D
Description: Homo sapiens sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D (SEMA3D), mRNA.
Gene Location: chr7(-):84624871-84751247
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr7:g.84995609T>C COSN6895609 RK176_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-586 tgttaAATGCATAttttgg
2
UAUGCAUU m8a Created -0.052000 -0.486000 0.100000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.84996286T>C COSN15110585 SM-4B296 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-494 agtATGTTTCgttcctgct
2
UGAAACAU m7b (m6c->m7b) 0.126000 0.092000 -1.430000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.84996562T>G COSN8042939 8069446 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-323a-3p ctaatTAATGTatgtagag
2
CACAUUAC m6b Created -0.045000 -0.009000 No effect


Mutation Mutation ID Sample Name Cancer Type
chr7:g.84996567T>C COSN2239844 RK051_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Mutation Mutation ID Sample Name Cancer Type
chr7:g.84996571C>T COSN15043711 LP6007594 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr7:g.84996733C>T COSN8042940 8033523 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3613-3p tcatgTTTTTGTatttttc
0 ACAAAAAA m7a Created NA NA -0.960000
hsa-miR-570-3p tcaTGTTTTCGtatttttc
0 CGAAAACA m8a Disrupted 0.040000 -0.001000 2.160000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.84996770C>T 9_16502 CRC-3-Tumor Colorectal adenocarcinoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4797-5p ttgACTCTGTggaggggat
2
GACAGAGU m7b (m6c->m7b) -0.17 -0.185 -0.06

Mutation Mutation ID Sample Name Cancer Type
chr7:g.84997082C>A COSN8042941 8069459 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3713 ctttGGATACaatactctt
3
GGUAUCCG m6b Disrupted -0.047000 no TS 2.390000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.84997288C>T COSN8042942 8058184 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-711 ttgTGGGTCCgacagtaat
2
GGGACCCA m7b (m7b->m6c) -0.093000 no TS 3.360000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.84997318T>A COSN2239845 RK023_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-656 attttTAATATaaaaaaaa
0 AAUAUUAU m6b Created no TS 0.133000 -0.010000
hsa-miR-656 attttTAATATaaaaaaaa
0 AAUAUUAU m6b Created no TS 0.133 -0.01

Mutation Mutation ID Sample Name Cancer Type
chr7:g.84998711G>C COSN9772674 C0094T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1179 ggacaGAATGCTTaataaa
0 AAGCAUUC m8a Disrupted -0.144000 no TS 1.010000
hsa-miR-4320 ggacAGAATCCttaataaa
3
GGGAUUCU m7b Created -0.072000 -0.192000 -0.530000
hsa-miR-4477b ggacagaaTCCTTAATaaa
2
AUUAAGGA m8a Created -0.005000 -0.140000 -0.420000
hsa-miR-4503 ggacagaaTGCTTAAtaaa
7
UUUAAGCA m7b Disrupted -0.112000 no TS No effect
hsa-miR-541-5p ggacagAATCCTTaataaa
0 AAAGGAUU m7b Created no TS -0.158000 -2.070000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.84998721G>A COSN9512640 AOCS-104-1-6 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3674 agcTCTACAAggacagaat
3
AUUGUAGA m7b (m6c->m7b) -0.013000 -0.041000 -0.020000
hsa-miR-670 agctctaCAGGGACagaat
0 GUCCCUGA m7a Disrupted NA NA 2.320000
hsa-miR-676-3p agctctacaAGGACAGaat
0 CUGUCCUA m7a (m6a->m7a) NA NA -0.030000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.84999002T>A COSN2239846 RK001_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4457 gctaCCTTGTGgtagggaa
6
UCACAAGG m7b Disrupted -0.229000 -0.063000 No effect
hsa-miR-4777-3p gctacctTGAGGTAgggaa
0 AUACCUCA m7b Created no TS -0.140000 -4.110000
hsa-miR-624-3p gctACCTTGTGgtagggaa
6
CACAAGGU m8a Disrupted -0.127000 no TS No effect
hsa-miR-4457 gctaCCTTGTGgtagggaa
0 UCACAAGG m7b Disrupted -0.229 -0.063 No effect
hsa-miR-4777-3p gctacctTGAGGTAgggaa
0 AUACCUCA m7b Created no TS -0.14 -4.11
hsa-miR-624-3p gctACCTTGTGgtagggaa
0 CACAAGGU m8a Disrupted -0.127 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr7:g.84999092C>T COSN4935485 PD4005a [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-181a-5p ttattccctTGAATGTcca
6
AACAUUCA m7b (m6b->m7b) 0.025000 -0.020000 -1.670000
hsa-miR-181b-5p ttattccctTGAATGTcca
6
AACAUUCA m7b (m6b->m7b) 0.025000 -0.010000 No effect
hsa-miR-181c-5p ttattccctTGAATGTcca
6
AACAUUCA m7b (m6b->m7b) 0.034000 -0.020000 -0.660000
hsa-miR-181d ttattccctTGAATGTcca
6
AACAUUCA m7b (m6b->m7b) 0.015000 -0.020000 No effect
hsa-miR-4262 ttattccctTGAATGTCca
6
GACAUUCA m8a (m7a->m8a) 0.043000 -0.011000 -0.220000
hsa-miR-4475 ttatTCCCTTGaatgtcca
7
CAAGGGAC m7a Created -0.185000 -0.185000 -3.940000
hsa-miR-561-5p ttattcCCTTGAatgtcca
0 AUCAAGGA m6b Created no TS -0.125000 -3.660000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.84999246A>G COSN2239847 RK137_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4273 tccaAGAACAaatcttgca
0 GUGUUCUC m6b Disrupted -0.049000 0.028000 0.010000
hsa-miR-4677-5p tccAAGAACAAatcttgca
0 UUGUUCUU m8a Disrupted -0.231000 -0.036000 0.110000
hsa-miR-4273 tccaAGAACAaatcttgca
0 GUGUUCUC m6b Disrupted -0.049 0.028 0.01
hsa-miR-4677-5p tccAAGAACAAatcttgca
0 UUGUUCUU m8a Disrupted -0.231 -0.036 0.11

Mutation Mutation ID Sample Name Cancer Type
chr7:g.84999365T>C COSN2239848 RK096_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-183-3p cccttatagTAATTCAtaa
2
GUGAAUUA m7b (m7b->m6b) -0.106000 0.042000 2.880000
hsa-miR-219-2-3p cccttatagCAATTCataa
0 AGAAUUGU m6b Created no TS -0.113000 No effect
hsa-miR-2964a-3p cccttataGCAATTCataa
0 AGAAUUGC m7b Created no TS -0.412000 -0.100000
hsa-miR-302f cccttatAGCAATTcataa
0 UAAUUGCU m7b Created 0.048000 -0.126000 No effect
hsa-miR-625-3p ccctTATAGTaattcataa
0 GACUAUAG m6b Disrupted -0.177000 -0.108000 No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
84995644 rs191959760 T
C hsa-miR-221-3p
hsa-miR-222-3p
hsa-miR-624-3p
9
9
12
ATGTAGCcttgta
ATGTAGCcttgta
atgtagCCTTGTA
Created
Created
Created
N
N
N
-0.268
-0.268
-0.168
84996732 rs138653004 G
A hsa-miR-4517
hsa-miR-570-3p
1
1
gtttTCATATTtt
GTTTTCAtatttt
Created
Created
N
N
-0.025
0.013
84996734 rs76283272 T T hsa-miR-570-3p
1
aTGTTTTCgtatt
Disrupted
N
0.041
C hsa-miR-4261
hsa-miR-494-3p
1
2
aTGTTTCCgtatt
ATGTTTCcgtatt
Created
Created
N
N
-0.035
0.083
84998054 rs189339965 G G hsa-miR-4275
hsa-miR-7849-3p
1
1
GTAATTGtagtat
gtAATTGTAgtat
Disrupted
Disrupted
N
N
-0.009
0.1
A hsa-miR-625-3p
1
gtaatTATAGTAt
Created
N
0.036
84998706 rs181521389 A A hsa-miR-4477a
hsa-miR-4503
hsa-miR-6792-5p
7
7
7
tgCTTAATAAata
TGCTTAAtaaata
TGCTTAAtaaata
Disrupted
Disrupted
Disrupted
N
N
N
-0.007
-0.112
-0.059
84999253 rs186298749 C C hsa-miR-3148
hsa-miR-3978
hsa-miR-432-5p
hsa-miR-6124
7
8
8
7
gTTTTCCAagaac
gtTTTCCAAgaac
gtttTCCAAGAac
gTTTTCCAagaac
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
-0.037
-0.046
-0.137
-0.033
A hsa-miR-510-3p
hsa-miR-570-3p
hsa-miR-6844
8
7
9
gtTTTCAAAgaac
GTTTTCAaagaac
gttttCAAAGAAc
Created
Created
Created
N
N
N
0.017
-0.018
-0.068

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