SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_014363
Gene Symbol:	SACS
Description:	Homo sapiens spastic ataxia of Charlevoix-Saguenay (sacsin) (SACS), mRNA.
Gene Location:	chr13(-):23902964-24007841
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.23329142C>G			COSN6224277		RK190_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-2110	cttatatTTCCCCAtgaat	0	UUGGGGAA	m7b	Disrupted	-0.268000	no TS	7.440000
hsa-miR-3153	cttataTTTCCCCatgaat	0	GGGGAAAG	m7a	Disrupted	NA	NA	8.640000
hsa-miR-4271	cttatatTTCCCCatgaat	0	GGGGGAAG	m6b	Disrupted	-0.158000	no TS	12.910000

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.23329150T>G			COSN8127384		ASHPC_0015_Pa_P		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.23329254A>-			ICGC_ssm_v3_10403		BN24T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.23329512A>T			COSN7396195		8035705		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4282	tttatttAAATTTTttttt	0	UAAAAUUU	m7b	Disrupted	0.210000	0.201000	0.040000

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.23329630T>A			COSN9744034		C0031T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3163	gttgtaATTTTATgttgta	3	UAUAAAAU	m7b	Disrupted	0.129000	0.077000	0.040000
hsa-miR-4803	gttgtaattTTATGTTgta	1	UAACAUAA	m7b	(m7b->m6b)	-0.219000	-0.178000	0.050000

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.23330124G>A			COSN8407360		B85-0-Tumor		[urinary_tract][bladder][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-129-5p	atatttaaCAAAAAaaaag	0	CUUUUUGC	m6b	Created	no TS	0.000000	No effect
hsa-miR-2053	atatTTAACAaaaaaaaag	0	GUGUUAAU	m6b	Created	no TS	0.000000	No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
23329511	rs186505479	T	T	hsa-miR-4282	0	tttAAATTTTttt	Disrupted	N	No Change
			A	hsa-miR-590-3p	0	ttTAAAATTtttt	Created	N	-0.025

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