SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001243996
Gene Symbol:	RYR3
Description:	Homo sapiens ryanodine receptor 3 (RYR3), transcript variant 1, mRNA.
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.33865300G>A			COSN9623900		C0066T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-298	tacagTTCTGCaacatatc	0	AGCAGAAG	m6b	Disrupted	-0.139000	no TS	12.770000
hsa-miR-3674	tacagtTCTACAAcatatc	0	AUUGUAGA	m7b	Created	no TS	-0.194000	-0.100000
hsa-miR-3678-3p	tacagtTCTGCAacatatc	0	CUGCAGAG	m6b	Disrupted	-0.142000	no TS	5.890000

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.33865316G>A			COSN8742299		AOCS-084-1-X		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-130a-5p	atctgaAATGTGAcatttt	0	UUCACAUU	m7b	Disrupted	-0.149000	no TS	2.390000
hsa-miR-23a-3p	atctgaAATGTGAcatttt	0	AUCACAUU	m7b	Disrupted	-0.149000	no TS	4.810000
hsa-miR-23b-3p	atctgaAATGTGAcatttt	0	AUCACAUU	m7b	Disrupted	-0.149000	no TS	4.560000
hsa-miR-23c	atctgaAATGTGAcatttt	0	AUCACAUU	m7b	Disrupted	-0.149000	no TS	3.910000

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.33865341A>-			ICGC_ssm_v3_10591		BN24T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4477b	gcctcCCTTAAaaaaaaaa	0	AUUAAGGA	m6b	Disrupted	-0.154000	-0.151000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.33865435G>A			COSN5396325		RK140_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3145-3p	tgtcaAAATATCgaagaag	0	AGAUAUUU	m7b	Created	-0.051000	-0.113000	-0.420000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
33865316	rs192105906	G	G	hsa-miR-130a-5p hsa-miR-23a-3p hsa-miR-23b-3p hsa-miR-23c	0	tgaAATGTGAcat tgaAATGTGAcat tgaAATGTGAcat tgaAATGTGAcat	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.149 -0.149 -0.149 -0.149
			A	hsa-miR-1279 hsa-miR-205-3p	0	tgaAATATGAcat TGAAATAtgacat	Created Created	N N	-0.027 -0.112
33865340	rs200704038	-	-	hsa-miR-4475 hsa-miR-4477b hsa-miR-6892-5p hsa-miR-7856-5p	0	cTCCCTTAaaaaa ctcCCTTAAAaaa cTCCCTTAAaaaa ctcCCTTAAAAaa	Unknown Unknown Unknown Unknown	N N N N	0.001 0.001 0.002 0.005
			A

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