SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001035
Gene Symbol:	RYR2
Description:	Homo sapiens ryanodine receptor 2 (cardiac) (RYR2), mRNA.
Gene Location:	chr1(+):237205701-237997288
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Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.237832680C>T			COSN6028473		RK121_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-197-5p	aaccaaaacTCTACCCctc	0	CGGGUAGA	m7b	(m6c->m7b)	no TS	-0.216000	1.000000
hsa-miR-296-3p	aaccaaAACCCTacccctc	32767	GAGGGUUG	m6b	Disrupted	-0.141000	no TS	3.130000
hsa-miR-3132	aaccaaaacTCTACCCctc	0	UGGGUAGA	m7b	(m6c->m7b)	no TS	-0.216000	-4.380000
hsa-miR-4451	aaccaaaaCTCTACCcctc	32767	UGGUAGAG	m7b	Created	no TS	-0.235000	-11.000000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.237833361C>G			COSN6449211		CHC197T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1908	cccccCCCCGCCGcccccg	32767	CGGCGGGG	m8a	Created	-0.243000	-0.292000	-1.340000
hsa-miR-3960	cccccccCCGCCGCCcccg	0	GGCGGCGG	m8a	Created	no TS	-0.192000	-0.320000
hsa-miR-4467	ccccccccCGCCGCCcccg	0	UGGCGGCG	m7b	Created	no TS	-0.140000	-3.910000
hsa-miR-663a	ccccccccCCCCGCCcccg	32767	AGGCGGGG	m7b	Disrupted	-0.299000	-0.311000	-3.700000
hsa-miR-1908	cccccCCCCGCCGcccccg	32767	CGGCGGGG	m8a	Created	-0.243000	-0.292000	-1.340000
hsa-miR-3960	cccccccCCGCCGCCcccg	0	GGCGGCGG	m8a	Created	no TS	-0.192000	-0.320000
hsa-miR-4467	ccccccccCGCCGCCcccg	0	UGGCGGCG	m7b	Created	no TS	-0.140000	-3.910000
hsa-miR-663a	ccccccccCCCCGCCcccg	32767	AGGCGGGG	m7b	Disrupted	-0.299000	-0.311000	-3.700000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.237833641G>A			COSN7469512		tumor_4163639		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][diffuse_large_B_cell_lymphoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-130a-5p	caacAATGTGAtacaatat	32767	UUCACAUU	m7b	Disrupted	-0.060000	no TS	-0.920000
hsa-miR-23a-3p	caacAATGTGATacaatat	32767	AUCACAUU	m8a	Disrupted	-0.097000	no TS	-0.140000
hsa-miR-23b-3p	caacAATGTGATacaatat	32767	AUCACAUU	m8a	Disrupted	-0.097000	no TS	-0.610000
hsa-miR-23c	caacAATGTGATacaatat	32767	AUCACAUU	m8a	Disrupted	-0.088000	no TS	-0.550000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.237833665T>G			COSN8970797		SS6003149		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1323	tgacagtAGTTTTGggttt	32767	UCAAAACU	m7b	Disrupted	-0.101000	-0.052000	0.030000
hsa-miR-548o-3p	tgacagtAGTTTTGGgttt	32767	CCAAAACU	m8a	Disrupted	-0.092000	-0.052000	2.100000
hsa-miR-606	tgacAGTAGTTTtgggttt	32767	AAACUACU	m8a	Disrupted	-0.124000	no TS	2.590000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
237833361	rs12406863	C	C	hsa-miR-1908-5p hsa-miR-663a hsa-miR-6787-5p	0	cccccCCCCGCCc cccccCCCCGCCc cccccCCCCGCCc	Disrupted Disrupted Disrupted	N N N	0.049 0.012 0.021
			G	hsa-miR-3960 hsa-miR-4467 hsa-miR-8072	0	ccccCCGCCGCcc cccccCGCCGCCc ccccCCGCCGCcc	Created Created Created	N N N	-0.192 -0.14 -0.183

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