SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_015485
Gene Symbol:	RWDD3
Description:	Homo sapiens RWD domain containing 3 (RWDD3), transcript variant 2, mRNA.
Gene Location:	chr1(+):95699710-95712781
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.95246952T>C			COSN8522295		AOCS-164-1-7		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-138-2-3p	taattGAAATAGtcaattt	3	GCUAUUUC	m7b	Disrupted	-0.193000	no TS	0.390000
hsa-miR-205-3p	taatTGAAATagtcaattt	2	GAUUUCAG	m6b	Disrupted	-0.048000	-0.039000	0.130000
hsa-miR-3136-5p	taattgaaaCAGTCAattt	0	CUGACUGA	m6b	Created	no TS	-0.176000	-0.440000
hsa-miR-4439	taattgaaaCAGTCAattt	0	GUGACUGA	m6b	Created	no TS	-0.176000	-1.980000
hsa-miR-452-5p	taattgAAACAGTcaattt	0	AACUGUUU	m7b	Created	no TS	-0.134000	-2.080000
hsa-miR-4676-3p	taattgAAACAGTcaattt	0	CACUGUUU	m7b	Created	no TS	-0.162000	-1.960000
hsa-miR-943	taattgaaACAGTCAattt	0	CUGACUGU	m7b	Created	no TS	-0.436000	-2.080000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.95247063C>T			COSN1110427		HCC61T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.95247189C>A			COSN6051019		RK053_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4676-5p	attttCTGGCTaattttct	6	GAGCCAGU	m6b	Disrupted	-0.244000	no TS	4.900000
hsa-miR-5586-5p	attttCTGGATAattttct	0	UAUCCAGC	m7a	Created	no TS	-0.219000	-6.280000
hsa-miR-575	attttCTGGCTaattttct	6	GAGCCAGU	m6b	Disrupted	-0.244000	no TS	8.480000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
95246902	rs592097	C	C	hsa-miR-141-3p hsa-miR-200a-3p	6 6	aaatagCAGTGTT aaatagCAGTGTT	Disrupted Disrupted	N N	-0.214 -0.204
			A	hsa-miR-138-2-3p hsa-miR-4482-3p	3 2	AAATAGAagtgtt aAATAGAAgtgtt	Created Created	N N	-0.038 -0.117
95247034	rs192560785	A	A	hsa-miR-205-3p hsa-miR-889-3p	2 10	taTGAAATAttaa tatgaaATATTAA	Disrupted Disrupted	N N	-0.039 -0.008
			G	hsa-miR-200b-3p hsa-miR-200c-3p hsa-miR-374c-5p hsa-miR-429 hsa-miR-655-3p hsa-miR-8084	9 9 10 9 10 9	tatgaAGTATTAa tatgaAGTATTAa tatgaaGTATTAA tatgaAGTATTAa tatgaaGTATTAA tatgaAGTATTAa	Created Created Created Created Created Created	N N N N N N	-0.047 -0.047 -0.042 -0.058 -0.049 -0.064

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