SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_001001890
Gene Symbol: RUNX1
Description: Homo sapiens runt-related transcription factor 1 (RUNX1), transcript variant 2, mRNA.
Gene Location: chr21(-):36160097-36260987
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr21:g.34787974G>A COSN7145145 8067182 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3689d gggtgggcCACCTCCCctc
0 GGGAGGUG m8a Created no TS -0.083000 -0.220000
hsa-miR-663b gggtGGGCCACCtcccctc
0 GGUGGCCC m8a Created no TS -0.206000 -1.120000

Mutation Mutation ID Sample Name Cancer Type
chr21:g.34788396T>G COSN10026018 C0007T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3609 aagtTCACTTTttttgttc
0 CAAAGUGA m7b Disrupted -0.212000 -0.079000 -0.040000
hsa-miR-3613-3p aagttcactTTTTTTGTtc
0 ACAAAAAA m8a (m8a->m7a) 0.566000 0.511000 No effect
hsa-miR-548ah-5p aagtTCACTTTTtttgttc
0 AAAAGUGA m8a Disrupted -0.184000 -0.088000 -0.030000
hsa-miR-548t-5p aagttCACTTTTtttgttc
0 CAAAAGUG m7b Disrupted -0.122000 -0.064000 -0.030000

Mutation Mutation ID Sample Name Cancer Type
chr21:g.34788477T>G COSN8611711 759_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3129-3p ctttgtTTAGTTTagactt
0 AAACUAAU m7a Created NA NA No effect
hsa-miR-5583-5p ctttgtTTAGTTTagactt
0 AAACUAAU m7a Created NA NA -0.010000


Mutation Mutation ID Sample Name Cancer Type
chr21:g.34788527A>T COSN10026019 C0035T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr21:g.34788822G>T COSN9157446 AOCS-097-1-X [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3613-3p tgaaaatTTTTTTGacaat
0 ACAAAAAA m7b Created 0.566000 0.704000 -3.130000
hsa-miR-4282 tgaAAATTTTtttgacaat
8
UAAAAUUU m7b (m6c->m7b) 0.378000 0.488000 -0.010000
hsa-miR-7-1-3p tgaaaATTTGTTtgacaat
2
CAACAAAU m7b Disrupted 0.200000 0.171000 No effect
hsa-miR-7-2-3p tgaaaATTTGTTtgacaat
2
CAACAAAU m7b Disrupted 0.181000 0.152000 2.100000

Mutation Mutation ID Sample Name Cancer Type
chr21:g.34788990T>A COSN5136171 PD4085a [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-34a-3p tgctCTGATTagaaaggaa
10
CAAUCAGC m6b Disrupted 0.086000 0.040000 0.010000
hsa-miR-361-5p tgcTCTGATAAgaaaggaa
3
UUAUCAGA m8a Created -0.021000 0.010000 No effect
hsa-miR-374a-3p tgctCTGATAAGaaaggaa
4
CUUAUCAG m8a Created 0.013000 0.019000 No effect
hsa-miR-4263 tgctctgaTTAGAAaggaa
10
AUUCUAAG m6b Disrupted 0.125000 no TS 0.010000
hsa-miR-576-5p tgctctgATTAGAAaggaa
10
AUUCUAAU m7b Disrupted 0.181000 no TS 1.730000

Mutation Mutation ID Sample Name Cancer Type
chr21:g.34789384T>A COSN1891500 RK086_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1278 tatttCAGTACTttctttt
15
UAGUACUG m7b Created -0.065000 -0.187000 -0.270000
hsa-miR-3133 tatttcaGTTCTTTctttt
0 UAAAGAAC m7b Disrupted 0.083000 0.038000 0.050000
hsa-miR-4511 tatttcAGTTCTTtctttt
0 GAAGAACU m7b Disrupted 0.296000 0.250000 No effect
hsa-miR-548av-5p tatttcaGTACTTTctttt
0 AAAAGUAC m7b Created no TS 0.034000 -0.020000
hsa-miR-548k tatttcaGTACTTTctttt
0 AAAAGUAC m7b Created no TS 0.034000 -0.010000
hsa-miR-1278 tatttCAGTACTttctttt
0 UAGUACUG m7b Created -0.065 -0.187 -0.27
hsa-miR-3133 tatttcaGTTCTTTctttt
0 UAAAGAAC m7b Disrupted 0.083 0.038 0.05
hsa-miR-4511 tatttcAGTTCTTtctttt
0 GAAGAACU m7b Disrupted 0.296 0.25 No effect
hsa-miR-548av-5p tatttcaGTACTTTctttt
0 AAAAGUAC m7b Created no TS 0.034 -0.02
hsa-miR-548k tatttcaGTACTTTctttt
0 AAAAGUAC m7b Created no TS 0.034 -0.01

Mutation Mutation ID Sample Name Cancer Type
chr21:g.34789387A>C COSN1891501 RK086_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-191-5p acatatTTCCGTTctttct
0 CAACGGAA m7b Created no TS -0.094000 No effect
hsa-miR-4511 acatatttcAGTTCTTtct
0 GAAGAACU m7b (m7b->m6b) 0.296000 0.250000 No effect
hsa-miR-191-5p acatatTTCCGTTctttct
0 CAACGGAA m7b Created no TS -0.094 No effect
hsa-miR-4511 acatatttcAGTTCTTtct
0 GAAGAACU m7b (m7b->m6b) 0.296 0.25 No effect

Mutation Mutation ID Sample Name Cancer Type
chr21:g.34789821T>G COSN1891502 RK133_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3188 aaaccAGCCTCatgctctg
3
AGAGGCUU m6b Disrupted -0.028000 no TS 0.300000
hsa-miR-3929 aaacCAGCCTCatgctctg
12
GAGGCUGA m7a Disrupted -0.010000 -0.010000 0.160000
hsa-miR-4419b aaacCAGCCTCatgctctg
12
GAGGCUGA m7a Disrupted -0.029000 -0.029000 0.150000
hsa-miR-4478 aaacCAGCCTCatgctctg
12
GAGGCUGA m7a Disrupted 0.018000 0.018000 0.130000
hsa-miR-485-5p aaacCAGCCTCatgctctg
0 AGAGGCUG m7b Disrupted -0.110000 -0.043000 2.910000
hsa-miR-3188 aaaccAGCCTCatgctctg
0 AGAGGCUU m6b Disrupted -0.028 no TS 0.3
hsa-miR-3929 aaacCAGCCTCatgctctg
0 GAGGCUGA m7a Disrupted -0.01 -0.01 0.16
hsa-miR-4419b aaacCAGCCTCatgctctg
0 GAGGCUGA m7a Disrupted -0.029 -0.029 0.15
hsa-miR-4478 aaacCAGCCTCatgctctg
0 GAGGCUGA m7a Disrupted 0.018 0.018 0.13
hsa-miR-485-5p aaacCAGCCTCatgctctg
0 AGAGGCUG m7b Disrupted -0.11 -0.043 2.91

Mutation Mutation ID Sample Name Cancer Type
chr21:g.34790435T>G COSN9157447 AOCS-116-1-3 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1226-3p tccaaatgaGCTGGTGgtt
1
UCACCAGC m7b (m6b->m7b) -0.279000 -0.363000 No effect
hsa-miR-4267 tccaaatGAGCTGGtggtt
0 UCCAGCUC m7b Created -0.115000 -0.217000 -4.190000
hsa-miR-5694 tccaaATGATCTGgtggtt
12
CAGAUCAU m8a Disrupted 0.063000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr21:g.34790525T>C COSN5452751 RK307_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-224-3p ttatggcACCATTTTtatt
0 AAAAUGGU m8a Created no TS 0.093000 -1.590000
hsa-miR-33b-3p ttatGGCACTatttttatt
0 CAGUGCCU m6b Disrupted -0.233000 -0.147000 4.500000
hsa-miR-371a-3p ttatGGCACTatttttatt
14
AAGUGCCG m6b Disrupted -0.127000 no TS 2.510000
hsa-miR-371b-3p ttatGGCACTatttttatt
14
AAGUGCCC m6b Disrupted -0.093000 no TS 0.610000
hsa-miR-515-3p ttatGGCACTatttttatt
0 GAGUGCCU m6b Disrupted -0.217000 -0.128000 6.280000
hsa-miR-519e-3p ttatGGCACTatttttatt
0 AAGUGCCU m6b Disrupted -0.215000 -0.119000 2.530000
hsa-miR-522-3p ttatggcACCATTTTtatt
0 AAAAUGGU m8a Created no TS 0.083000 -0.550000

Mutation Mutation ID Sample Name Cancer Type
chr21:g.34791522A>T cosmic_v64_1760549 Leukemia/T-ALL
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3124-3p catGGAAAGTaatatgatt
0 ACUUUCCU m7a (m6b->m7a) 0.152 0.197 -0.01

Mutation Mutation ID Sample Name Cancer Type
chr21:g.34791822G>A COSN5769094 HX33T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1470 aagattccCGGAGGGaaac
0 GCCCUCCG m7b Disrupted -0.519000 -0.140000 5.490000
hsa-miR-204-3p aagaTTCCCAGagggaaac
4
GCUGGGAA m7b Created -0.122000 -0.346000 -0.060000
hsa-miR-326 aagattCCCAGAGGgaaac
0 CCUCUGGG m8a Created no TS -0.258000 -0.670000
hsa-miR-330-5p aagattCCCAGAGggaaac
0 UCUCUGGG m7b Created no TS -0.202000 -0.050000
hsa-miR-4314 aagatTCCCAGAGggaaac
3
CUCUGGGA m8a Created -0.398000 -0.548000 -0.050000
hsa-miR-4497 aagatTCCCGGAGggaaac
4
CUCCGGGA m8a Disrupted -0.287000 no TS 1.110000
hsa-miR-4646-5p aagaTTCCCAGagggaaac
4
ACUGGGAA m7b Created -0.129000 -0.406000 -0.400000
hsa-miR-4667-3p aagattcccGGAGGGAaac
0 UCCCUCCU m7a (m7a->m6a) -0.468000 -0.308000 0.900000
hsa-miR-642a-5p aagattcccAGAGGGAaac
0 GUCCCUCU m7b (m6b->m7b) -0.127000 -0.297000 0.270000

Mutation Mutation ID Sample Name Cancer Type
chr21:g.34791884C>T COSN15001571 LP6007414-DNA_A02 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-18a-5p gacGCACCTTgagggtgtc
17
UAAGGUGC m7b (m6c->m7b) -0.305000 -0.355000 No effect
hsa-miR-18b-5p gacGCACCTTgagggtgtc
17
UAAGGUGC m7b (m6c->m7b) -0.295000 -0.345000 No effect
hsa-miR-4735-3p gacGCACCTTgagggtgtc
17
AAAGGUGC m7b (m6c->m7b) -0.389000 -0.457000 No effect
hsa-miR-4761-5p gacgCACCTTGagggtgtc
0 ACAAGGUG m7b Created no TS -0.179000 -0.070000

Mutation Mutation ID Sample Name Cancer Type
chr21:g.34792014G>C cosmic_v64_1860009 Esophageal
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1307-3p ccgtcctggCGCCGAGggc
0 ACUCGGCG m7b (m6b->m7b) no TS -0.15 -0.97
hsa-miR-1469 ccgtcctgGCGCCGAGggc
0 CUCGGCGC m8a Created no TS -0.269 -1.14

Mutation Mutation ID Sample Name Cancer Type
chr21:g.34792097C>T COSN5769095 HCC159 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3714 gcgggccgCTGCCTTCgcc
2
GAAGGCAG m8a Created -0.074000 -0.053000 No effect
hsa-miR-3960 gcgggCCGCCGCCttcgcc
0 GGCGGCGG m8a Disrupted -0.524000 -0.244000 No effect
hsa-miR-4467 gcgggcCGCCGCCttcgcc
0 UGGCGGCG m7b Disrupted -0.698000 -0.479000 No effect
hsa-miR-885-3p gcgggcCGCTGCCTtcgcc
0 AGGCAGCG m8a Created no TS -0.110000 No effect
hsa-miR-3714 gcgggccgCTGCCTTCgcc
2
GAAGGCAG m8a Created -0.074000 -0.053000 No effect
hsa-miR-3960 gcgggCCGCCGCCttcgcc
0 GGCGGCGG m8a Disrupted -0.524000 -0.244000 No effect
hsa-miR-4467 gcgggcCGCCGCCttcgcc
0 UGGCGGCG m7b Disrupted -0.698000 -0.479000 No effect
hsa-miR-885-3p gcgggcCGCTGCCTtcgcc
0 AGGCAGCG m8a Created no TS -0.110000 No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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