SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001142285
Gene Symbol:	RPS24
Description:	Homo sapiens ribosomal protein S24 (RPS24), transcript variant c, mRNA.
Gene Location:	chr10(+):79793517-79816571
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.78055310T>A			COSN1122888		HCC64T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3163	tgATTTTATAattttcttg	2	UAUAAAAU	m8a	(m7a->m8a)	0.032000	0.044000	No effect
hsa-miR-5692a	tgattttATTATTTtcttg	0	CAAAUAAU	m7b	Disrupted	-0.012000	no TS	0.030000
hsa-miR-3163	tgATTTTATAattttcttg	0	UAUAAAAU	m8a	(m7a->m8a)	0.032	0.044	No effect
hsa-miR-5692a	tgattttATTATTTtcttg	0	CAAAUAAU	m7b	Disrupted	-0.012	no TS	0.03

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.78055341G>T			COSN1122889		HCC49T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4460	ttcCCACTATaaatgaagc	0	AUAGUGGU	m7a	(m6a->m7a)	NA	NA	0.370000
hsa-miR-4727-3p	ttCCCACTATaaatgaagc	2	AUAGUGGG	m8a	(m7a->m8a)	-0.282000	-0.310000	0.140000
hsa-miR-4729	ttcccactATAAATGAagc	2	UCAUUUAU	m8a	Created	-0.085000	-0.194000	-6.080000
hsa-miR-5696	ttcccactaTAAATGAagc	2	CUCAUUUA	m7b	(m6c->m7b)	0.030000	-0.079000	No effect
hsa-miR-4460	ttcCCACTATaaatgaagc	0	AUAGUGGU	m7a	(m6a->m7a)	NA	NA	0.37
hsa-miR-4727-3p	ttCCCACTATaaatgaagc	0	AUAGUGGG	m8a	(m7a->m8a)	-0.282	-0.31	0.14
hsa-miR-4729	ttcccactATAAATGAagc	0	UCAUUUAU	m8a	Created	-0.085	-0.194	-6.08
hsa-miR-5696	ttcccactaTAAATGAagc	0	CUCAUUUA	m7b	(m6c->m7b)	0.03	-0.079	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.78056013C>A			ICGC_82CC9620-2A78-11E2-96E7-04FD496BB9B8		CPCG_0102_Pr_P_P1		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4425	gccTCCCAACgtgctggga	2	UGUUGGGA	m7b	(m7b->m6b)	-0.024	no TS	2.72

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.78056175G>A			COSN14638616		PCSI_0072_Pa_P_526		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-197-3p	gggtctgtcGTGGTGActg	4	UUCACCAC	m7b	(m7b->m6c)	-0.141000	-0.065000	No effect
hsa-miR-197-3p	gggtctgtcGTGGTGActg	4	UUCACCAC	m7b	(m7b->m6c)	-0.141000	-0.065000	No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
78056175	rs184653314	G	G	hsa-miR-197-3p	4	tctgtcGTGGTGA	Disrupted	N	-0.076

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