SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_015203
Gene Symbol:	RPRD2
Description:	Homo sapiens regulation of nuclear pre-mRNA domain containing 2 (RPRD2), mRNA.
Gene Location:	chr1(+):150336989-150449041
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.150473362C>A			COSN8308797		TCGA-A7-A3RF-01		[breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-151a-3p	cattttgaaCAGTCTAGag	12	CUAGACUG	m8a	(m8a->m7b)	-0.247000	no TS	0.050000
hsa-miR-4463	cattttgaaCAGTCTagag	12	GAGACUGG	m6b	Disrupted	-0.150000	no TS	No effect
hsa-miR-4499	cattttgaaCAGTCTagag	12	AAGACUGA	m6b	Disrupted	-0.131000	no TS	No effect
hsa-miR-5003-3p	cattttGAAAAGTctagag	0	UACUUUUC	m7b	Created	0.272000	0.141000	No effect
hsa-miR-607	catTTTGAACagtctagag	12	GUUCAAAU	m7a	(m7a->m6a)	-0.003000	0.004000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.150473757A>C			COSN6002464		RK190_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.150473930A>G			COSN7465834		tumor_4135099		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-532-5p	tttaAAGGCATGttgaagt	10	CAUGCCUU	m8a	Disrupted	-0.372000	-0.200000	0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.150475304T>C			COSN4900753		CPCG_0042_Pr_P_F0		[prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-2276	ggtttttttCTTGCAGAaa	5	UCUGCAAG	m8a	(m7b->m8a)	-0.029000	-0.125000	-0.560000
hsa-miR-3613-3p	ggttttTTTTTTGcagaaa	0	ACAAAAAA	m7b	Disrupted	0.387000	0.283000	No effect
hsa-miR-518a-5p	ggtttttttTTTGCAGaaa	0	CUGCAAAG	m7a	(m7a->m6b)	NA	NA	0.080000
hsa-miR-527	ggtttttttTTTGCAGaaa	0	CUGCAAAG	m7a	(m7a->m6b)	NA	NA	0.080000
hsa-miR-548aw	ggttttttTTTTGCAgaaa	6	GUGCAAAA	m7b	Disrupted	-0.022000	no TS	No effect
hsa-miR-2276	ggtttttttCTTGCAGAaa	0	UCUGCAAG	m8a	(m7b->m8a)	-0.029	-0.125	-0.56
hsa-miR-3613-3p	ggttttTTTTTTGcagaaa	4	ACAAAAAA	m7b	Disrupted	0.387	0.283	No effect
hsa-miR-518a-5p	ggtttttttTTTGCAGaaa	0	CUGCAAAG	m7a	(m7a->m6b)	NA	NA	0.08
hsa-miR-527	ggtttttttTTTGCAGaaa	0	CUGCAAAG	m7a	(m7a->m6b)	NA	NA	0.08
hsa-miR-548aw	ggttttttTTTTGCAgaaa	0	GUGCAAAA	m7b	Disrupted	-0.022	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.150475512G>T			COSN8319665		PCSI_0082_Pa_P_526		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.150475556G>C			9_369		CRC-2-Tumor		Colorectal adenocarcinoma
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4720-3p	gcttTTAAGCAgttgggtt	7	UGCUUAAG	m7a	Created	0.028	0.059	1.4
hsa-miR-4804-3p	gcttTTAAGCAgttgggtt	7	UGCUUAAC	m7a	Created	no TS	0.024	-4.04

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.150475569G>A			COSN8636168		742_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4286	tgggtttttGTGGGGTact	0	ACCCCACU	m7a	(m7a->m6b)	-0.492000	-0.492000	0.090000
hsa-miR-548ac	tgGGTTTTTGtggggtact	0	CAAAAACC	m8a	(m8a->m7a)	0.109000	0.114000	0.020000
hsa-miR-548d-3p	tgGGTTTTTGtggggtact	0	CAAAAACC	m8a	(m8a->m7a)	0.134000	0.141000	0.050000
hsa-miR-548h-3p	tgGGTTTTTGtggggtact	0	CAAAAACC	m8a	(m8a->m7a)	0.146000	0.152000	No effect
hsa-miR-548z	tgGGTTTTTGtggggtact	0	CAAAAACC	m8a	(m8a->m7a)	0.146000	0.152000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.150475957G>A			COSN6002465		RK308_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1911-5p	aggtccttGGTACTCActg	2	UGAGUACC	m8a	Disrupted	-0.336000	no TS	0.050000
hsa-miR-561-5p	aggTCCTTGATactcactg	1	AUCAAGGA	m8a	Created	-0.046000	-0.178000	-1.490000
hsa-miR-624-5p	aggtcctTGGTACTcactg	2	UAGUACCA	m7b	Disrupted	-0.182000	no TS	0.860000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.150476212G>A			COSN5731700		HX30T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1343	caataCCAGGAataaaatg	11	CUCCUGGG	m6b	Disrupted	-0.143000	no TS	2.590000
hsa-miR-4490	caaTACCAGAaataaaatg	0	UCUGGUAA	m7a	(m6a->m7a)	no TS	-0.151000	-0.020000
hsa-miR-4774-5p	caATACCAGAaataaaatg	3	UCUGGUAU	m8a	(m7a->m8a)	-0.212000	-0.369000	-0.490000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.150476475AAAAC>-			ICGC_ssm_v2_123163		HX16T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3692-3p	gtgttcggTGTGGAAaacaaaacaagt	13	GUUCCACA	m7b	Disrupted	-0.310000	-0.305000	1.410000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
150473366	rs145871523	T	C	hsa-miR-1251-5p hsa-miR-151a-3p hsa-miR-4305 hsa-miR-4463 hsa-miR-4499 hsa-miR-517-5p	16 12 12 12 12 13	aacagtCTAGAGA aaCAGTCTAgaga aacaGTCTAGAga aaCAGTCTAgaga aaCAGTCTAgaga aacagTCTAGAGA	Created Created Created Created Created Created	N N N N N N	-0.148 -0.247 -0.158 -0.15 -0.131 -0.349
			T	hsa-miR-520f-5p hsa-miR-548av-3p hsa-miR-548g-3p	13 12 11	aacagTTTAGAGA aaCAGTTTAgaga aACAGTTTAgaga	Disrupted Disrupted Disrupted	N N N	-0.207 -0.072 -0.261
150473580	rs76993680	-	GTA	hsa-miR-5003-3p	0	aaaaAAAAGTAaagaaa	Unknown	N	-0.036
			-
150475296	rs201235561	-	-	hsa-miR-548ac hsa-miR-548d-3p hsa-miR-548h-3p hsa-miR-548z	0	aaataGGTTTTTt aaataGGTTTTTt aaataGGTTTTTt aaataGGTTTTTt	Unknown Unknown Unknown Unknown	N N N N	0.005 0.005 0.005 0.005
			T
150475297	rs35529963	-	T	hsa-miR-548ac hsa-miR-548d-3p hsa-miR-548h-3p hsa-miR-548z	0	aataGGTTTTTtt aataGGTTTTTtt aataGGTTTTTtt aataGGTTTTTtt	Unknown Unknown Unknown Unknown	N N N N	-0.004 -0.004 -0.004 -0.004
			-
150475939	rs184242753	G	G	hsa-miR-1229-3p hsa-miR-342-3p	3 3	atGTGAGAAgttg aTGTGAGAagttg	Disrupted Disrupted	N N	-0.078 -0.062
			A	hsa-miR-130a-5p hsa-miR-23a-3p hsa-miR-23b-3p hsa-miR-23c hsa-miR-5003-3p hsa-miR-5096	2 2 2 2 4 3	ATGTGAAaagttg ATGTGAAaagttg ATGTGAAaagttg ATGTGAAaagttg atgtGAAAAGTtg atGTGAAAAgttg	Created Created Created Created Created Created	N N N N N N	-0.068 -0.066 -0.066 -0.066 -0.031 0.006
150476475	rs142336167	-	AAAAC	hsa-miR-3692-3p	13	ttcggTGTGGAAAacaaaaca	Unknown	N	-0.005
			-

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