SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_017763
Gene Symbol:	RNF43
Description:	Homo sapiens ring finger protein 43 (RNF43), mRNA.
Gene Location:	chr17(-):56431037-56494931
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.58354883C>T			COSN6107989		RK308_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1202	cctacCTGGCACagagtcc	0	GUGCCAGC	m7a	Disrupted	NA	NA	0.980000
hsa-miR-1227	cctaccTGGCACagagtcc	7	CGUGCCAC	m6b	Disrupted	-0.141000	no TS	0.600000
hsa-miR-1911-3p	cctaCCTGGTacagagtcc	0	CACCAGGC	m6b	Created	no TS	-0.142000	-3.710000
hsa-miR-4755-3p	cctaCCTGGCacagagtcc	6	AGCCAGGC	m6b	Disrupted	-0.144000	no TS	0.070000
hsa-miR-5006-5p	cctaCCTGGCAcagagtcc	6	UUGCCAGG	m7b	Disrupted	-0.221000	no TS	1.120000
hsa-miR-5008-3p	cctacctgGCACAGagtcc	8	CCUGUGCU	m6b	Disrupted	-0.139000	no TS	0.250000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.58354893C>T			COSN8840648		AOCS-166-1-2		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1296	gtgtttgGGCCCTAcctgg	5	UUAGGGCC	m7b	Disrupted	-0.254000	no TS	1.410000
hsa-miR-296-5p	gtgtttGGGCCCTacctgg	0	AGGGCCCC	m7a	Disrupted	NA	NA	No effect
hsa-miR-3136-3p	gtgtTTGGGCCctacctgg	2	UGGCCCAA	m7b	Disrupted	-0.236000	no TS	No effect
hsa-miR-4512	gtgtttgGGCCCTacctgg	5	CAGGGCCU	m6b	Disrupted	-0.213000	no TS	No effect
hsa-miR-711	gtgttTGGGTCCtacctgg	0	GGGACCCA	m7b	Created	no TS	-0.270000	-0.140000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
58353841	rs184733847	G	G	hsa-miR-3064-3p hsa-miR-4715-3p	1 1	aatgtgGTGGCAA aatgtGGTGGCAA	Disrupted Disrupted	N N	-0.167 -0.444
			C	hsa-miR-1202 hsa-miR-3194-5p hsa-miR-3972 hsa-miR-5006-5p	1 1 1 1	aatgtGCTGGCAA aatgtGCTGGCAa aatgtGCTGGCAA aatgtgCTGGCAA	Created Created Created Created	N N N N	-0.425 -0.181 -0.467 -0.139

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