SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_207111
Gene Symbol:	RNF216
Description:	Homo sapiens ring finger protein 216 (RNF216), transcript variant 1, mRNA.
Gene Location:	chr7(-):5659671-5821361
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr7:g.5622627C>G			COSN9994800		AOCS-141-3-2		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3184-5p	tgtgaactGCCCCTCccct	1	UGAGGGGC	m7b	Disrupted	-0.354000	-0.160000	2.470000
hsa-miR-423-5p	tgtgaactGCCCCTCccct	1	UGAGGGGC	m7b	Disrupted	-0.336000	-0.151000	0.040000
hsa-miR-4640-5p	tgtgaaCTGGCCCtcccct	2	UGGGCCAG	m7b	Created	-0.606000	-0.845000	-0.010000
hsa-miR-4688	tgtgaacTGCCCCTcccct	1	UAGGGGCA	m7b	Disrupted	-0.124000	no TS	0.010000
hsa-miR-4726-5p	tgtgaaCTGGCCCTcccct	2	AGGGCCAG	m8a	Created	-0.627000	-0.820000	No effect
hsa-miR-486-3p	tgtgaaCTGCCCCtcccct	0	CGGGGCAG	m7b	Disrupted	-0.227000	-0.026000	No effect
hsa-miR-548au-3p	tgtgAACTGCCcctcccct	0	UGGCAGUU	m7b	Disrupted	-0.169000	-0.076000	2.400000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
5620048	rs77494326	T	T	hsa-miR-4419a hsa-miR-4468 hsa-miR-4510 hsa-miR-6081 hsa-miR-6127 hsa-miR-6129 hsa-miR-6130 hsa-miR-6133 hsa-miR-6797-5p	4 4 4 4 4 4 4 4 2	ctctgCTCCCTCc cTCTGCTCcctcc ctctgCTCCCTCc ctCTGCTCCctcc ctctgCTCCCTCc ctctgCTCCCTCc ctctgCTCCCTCc ctctgCTCCCTCc ctctgcTCCCTCC	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N	-0.196 -0.097 -0.177 -0.221 -0.159 -0.149 -0.168 -0.177 -0.206
			C	hsa-miR-486-3p hsa-miR-6805-5p	4 4	ctCTGCCCCctcc ctctGCCCCCTcc	Created Created	N N	-0.261 -0.282
5621760	rs201394644	-	TG	hsa-miR-4640-5p hsa-miR-4726-5p hsa-miR-6508-3p hsa-miR-759	2 2 3 2	tcactCTGGCCCAtt tcactCTGGCCCAtt tcactcTGGCCCAtt tCACTCTGgcccatt	Unknown Unknown Unknown Unknown	N N N N	-0.237 -0.279 -0.109 0.01
			-	hsa-miR-4649-5p hsa-miR-6729-5p	2 2	tcaCTCGCCCAtt tcaCTCGCCCAtt	Unknown Unknown	N N	-0.323 -0.323

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