SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_017909
Gene Symbol:	RMND1
Description:	Homo sapiens required for meiotic nuclear division 1 homolog (S. cerevisiae) (RMND1), mRNA.
Gene Location:	chr6(-):151725988-151773316
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.151404875A>T			COSN2147612		RK036_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-5701	ataaACAATAAaataaata	1	UUAUUGUC	m7a	Disrupted	-0.111000	no TS	2.070000
hsa-miR-5701	ataaACAATAAaataaata	0	UUAUUGUC	m7a	Disrupted	-0.111	no TS	2.07

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.151405129C>G			ICGC_7BBF99CC-2A78-11E2-96E7-04FD496BB9B8		CPCG_0102_Pr_P_P1		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-150-5p	cagcactTTGGGAGgccaa	1	UCUCCCAA	m7b	Created	-0.084	-0.203	No effect
hsa-miR-17-5p	caGCACTTTGggaggccaa	0	CAAAGUGC	m8a	(m7b->m8a)	-0.064	-0.064	2.88
hsa-miR-186-3p	cagcaCTTTGGGaggccaa	0	GCCCAAAG	m7b	Created	no TS	-0.238	-3.53
hsa-miR-20b-5p	caGCACTTTGggaggccaa	0	CAAAGUGC	m8a	(m7b->m8a)	-0.054	-0.054	2.88
hsa-miR-519d	caGCACTTTGggaggccaa	0	CAAAGUGC	m8a	(m7b->m8a)	-0.064	-0.064	2.87
hsa-miR-520g	cagCACTTTGggaggccaa	0	ACAAAGUG	m7b	(m6c->m7b)	no TS	-0.007	-0.34
hsa-miR-520h	cagCACTTTGggaggccaa	0	ACAAAGUG	m7b	(m6c->m7b)	no TS	-0.007	-0.34
hsa-miR-526b-3p	caGCACTTTCggaggccaa	0	GAAAGUGC	m8a	(m8a->m7b)	-0.064	-0.064	2.88
hsa-miR-93-5p	caGCACTTTGggaggccaa	0	CAAAGUGC	m8a	(m7b->m8a)	-0.054	-0.054	2.88

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.151405207A>C			COSN6589515		ICGC_MB57		[central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-143-5p	gtcACTGCACgagatattc	2	GGUGCAGU	m7b	(m6c->m7b)	-0.145000	-0.349000	-0.780000
hsa-miR-3675-3p	gtcactgcaAGAGATattc	4	CAUCUCUA	m6b	Disrupted	-0.117000	no TS	2.340000
hsa-miR-517a-3p	gtcacTGCACGAgatattc	0	AUCGUGCA	m7b	Created	no TS	-0.344000	-2.370000
hsa-miR-517b-3p	gtcacTGCACGAgatattc	0	AUCGUGCA	m7b	Created	no TS	-0.344000	-2.370000
hsa-miR-517c-3p	gtcacTGCACGAgatattc	0	AUCGUGCA	m7b	Created	no TS	-0.335000	-1.970000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
151404874	rs35871051	-	-	hsa-miR-5701	1	taaACAATAAaataaataa	Unknown	N	0.001
			AAAT
151405207	rs200676006	A	A	hsa-miR-3675-3p hsa-miR-6516-5p	4 4	actgcaAGAGATA ACTGCAAgagata	Disrupted Disrupted	N N	-0.117 -0.163
			G	hsa-miR-17-3p hsa-miR-1976	4 7	ACTGCAGgagata actGCAGGAGAta	Created Created	N N	-0.219 -0.487

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